Clinical trials: Severe Asthma Exacerbation
Bronchial Asthma
Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.
Many studies have investigated the efficacy and safety of Intravenous magnesium sulfate and inhaled steroids in addition to the standard treatment for patients with severe asthma attacks.
- Trial name
- NCT02455687
- Testing
- Hi-dose iv MgSO4, Nebulized budesonide, Std-dose iv MgSO4
- Where
- Qatar
- Volunteers
- 240 people
- Sponsor
- Hamad Medical Corporation
Asthma
REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study
This is a prospective, real-world, single arm, global, multi-centre study to evaluate the effect of timely treatment with mepolizumab (NUCALA) to achieve clinical remission in adult participants with severe asthma with an…
- Trial name
- REIMAGINE (NCT06041386)
- Testing
- Mepolizumab, Spirometry
- Where
- 65 sites in United States, Belgium and 7 more
- Volunteers
- 336 people
- Sponsor
- GlaxoSmithKline
Asthma in Children
BiPAP in Pediatric Moderate to Severe Asthma Randomized Control Trial
The goal of this clinical trial is to study if starting bi-level positive airway pressure (BiPAP), a mask that gives pressure to the lungs, works well for children in the emergency department with moderate to severe asthma…
- Trial name
- NCT05848115
- Testing
- Bi-level Positive Airway Pressure
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Colorado, Denver
Asthma
Asthma Exacerbation Study
Asthma is a clinical syndrome that is well recognized by health care practitioners, yet asthma pathogenesis still remains poorly understood.
- Trial name
- NCT00853411
- Testing
- prednisone
- Sponsor
- University of Pittsburgh
Asthma Acute, Asthma Attack
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department.
- Conditions
- Asthma Acute, Asthma Attack, Asthma Exacerbations
- Trial name
- KET-AIR (NCT07112456)
- Testing
- Nebulized ketamine (0.5 mg/kg in normal saline to a total volume of 5ml) plus standard asthma excaerbationcare
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Medical Speciality Board
Asthma
Study of Pulmozyme to Treat Severe Asthma Episodes
Even with current standard ED treatments 20-25% of patients presenting to the ED with an acute asthma episode will still require hospitalization. For patients unresponsive to beta-agonists the admit rates will be higher.
- Trial name
- NCT00169962
- Testing
- rhDNAse (pulmozyme)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Northwell Health
Asthma
Efficacy of Oral AB1010 in Adult Patients With Severe Persistent Corticosteroid Dependent Asthma
The aim of the study is to evaluate, comparatively to a placebo, the activity of oral AB1010, administered at three dose levels during 4 months to patients with severe persistent corticosteroid dependent asthma, assessed on : the…
- Trial name
- NCT00842270
- Testing
- AB1010
- Volunteers
- 44 people
- Sponsor
- AB Science
Asthma
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week…
- Trial name
- NCT04129931
- Testing
- MCT, Clazakizumab, Broncho-Vaxom
- Where
- 29 sites in United States
- Volunteers
- 950 people
- Sponsor
- University of North Carolina, Chapel Hill
Asthma
Dose Ranging Efficacy And Safety With Mepolizumab in Severe Asthma
The purpose of this study is to show whether mepolizumab given every 4 weeks intravenously (i.v.) can reduce the frequency of asthma exacerbations in subjects with severe asthma despite receiving high doses of standard asthma…
- Trial name
- DREAM (NCT01000506)
- Testing
- Mepolizumab 750, Mepolizumab 250, Mepolizumab 75
- Where
- 94 sites in United States, Argentina and 11 more
- Volunteers
- 621 people
- Sponsor
- GlaxoSmithKline
Asthma, Chronic Inflammatory Diseases
Predictive Factors for Exacerbation Outcome in Severe Refractory Asthmatics
Asthma is a chronic inflammatory disease, affecting up to 10 % of the general population in developed countries. Corticosteroids are necessary to control symptoms, but induce adverse events sometimes intolerable.
- Trial name
- EXPRESA (NCT00721097)
- Testing
- spirometry, and blood taken
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital
Asthma Acute, Exacerbation of Allergic Asthma
Nebulized Ketamine for Severe Asthma Attacks in Children
This is a double-blinded, randomised, placebo-controlled trial enrolling 60 children aged 1 to 13 years with severe asthma exacerbation. All participants will receive standard therapy.
- Trial name
- NCT07728851
- Testing
- Ketamine (1 mg/kg)
- Where
- Oman
- Volunteers
- 60 people
- Sponsor
- Sultan Qaboos University
Preschool Severe Asthma
Preschool Bronchial Remodeling and Risk of Exacerbation
Bronchial remodeling is an abnormal tissue repair process of the bronchial wall components that characterizes severe asthma which can include epithelial abrasion, thickening of the reticular basement membrane (RBM), an increase…
- Trial name
- RESPIRE (NCT04558671)
- Testing
- asthma exacerbations
- Where
- 2 sites in France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Bordeaux
Asthma
Thyroid Hormones Treatment in Asthma Exacerbation
This study will explore whether supplementation with thyroid hormones in the set-up of asthma exacerbation could improve the clinical outcomes.
- Trial name
- THINAS (NCT02086799)
- Testing
- IV thyroxin
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Asthma Attack, Asthma
Benralizumab Initiated During Severe Asthma Attack
Approximately 300 million people have asthma worldwide and 400,000 people died from asthma globally in 2015 (GINA Asthma). Singapore's asthma mortality and hospitalisation rates are several times higher than OECD countries.
- Trial name
- NCT04617171
- Testing
- Benralizumab 30 MG/ML [Fasenra]
- Where
- Singapore
- Volunteers
- 128 people
- Sponsor
- Singapore General Hospital
Asthma, Acute Asthma
Effect of Addition of Single Dose of Oral Montelukast to Standard Treatment in Acute Asthma in Preschool Children.
The purpose of this study is to determine if adding single dose of oral montelukast to the standard treatment of systemic glucocorticoids plus short acting beta-2 agonist for treatment of acute wheezing provide additional…
- Trial name
- NCT01304901
- Testing
- montelukast 4 mg granule
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kecioren Education and Training Hospital
Allergic Asthma, Uncontrolled Moderate to Severe
Efficacy and Safety of Zerafil® (Omalizumab) in Participants With Uncontrolled Moderate to Severe Allergic Asthma
The purpose of this study is to evaluate the efficacy and safety of Omalizumab produced by CinnaGen compared with Xolair® (Genentech, Inc., USA And Novartis Pharmaceuticals Corp, Switzerland) in subjects with uncontrolled…
- Trial name
- NCT05813470
- Testing
- Omalizumab (CinnaGen), Omalizumab (Genentech, Inc., USA and Novartis Pharmaceuticals Corp, Switzerland)
- Where
- 22 sites in Iran
- Volunteers
- 256 people
- Sponsor
- Cinnagen
Asthma
Bronchial Thermoplasty in Severe Asthma With Frequent Exacerbations
The purpose of this study is to demonstrate the effectiveness of bronchial thermoplasty in a severe asthmatic population with frequent exacerbations. This will be a single center randomized and controlled study.
- Trial name
- THERMASCORT (NCT02464995)
- Testing
- Bronchial thermoplasty with the Alair System
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Strasbourg, France
Pediatric Asthma, Acute Asthma
Bilevel Positive Airway Pressure (BPAP) for Severe Asthma
The goal of this clinical trial is to assess the feasibility of early initiation of bilevel positive airway pressure (BPAP) in the emergency department (ED) for children with severe asthma exacerbations.
- Conditions
- Pediatric Asthma, Acute Asthma, BiPAP, Non-invasive Positive Pressure Ventilation
- Trial name
- NCT07582211
- Testing
- Bilevel positive airway pressure ventilation
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Columbia University
Asthma
Creation of Home-based Asthma Real-World Measures With Mobile Health Study
Four novel biologic therapies (benralizumab, dupilumab, mepolizumab, reslizumab) have been recently approved for moderate-to-severe, eosinophilic or oral steroid-dependent asthma.
- Trial name
- CHARM (NCT04462224)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Jewish Health
Asthma
Inflammatory and Immune Profiles During a Severe Exacerbation in Preschool Asthmatic Children (<5 Years)
Asthma/wheeze begins in the first years of life and is the most common chronic disease in preschool children (< 5 years). Different phenotypes have been suggested: Episodic-Viral Wheeze (EVW), absence of symptoms between…
- Trial name
- VIRASTHMA2 (NCT03960359)
- Testing
- Clinical, microbiological and inflammatory phenotype
- Volunteers
- 150 people
- Sponsor
- University Hospital, Lille