Clinical trials: Severe Brain Injury
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Brain Injuries, Traumatic
Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan
The purpose of this trial is to determine if mild hypothermia therapy, for severe head trauma patients, improves neurological outcome.
- Trial name
- NCT00134472
- Testing
- Therapeutic mild hypothermia
- Where
- 43 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Yamaguchi University Hospital
Intraocular Pressure, Intracranial Pressure Increase
Correlation Intraocular Pressure With Intracranial Pressure
Severe Trauma Brain Injury (TBIs) is a public health problem and monitoring of Intracranial Pressure (ICP) is a determinant key of it prognosis.
- Conditions
- Intraocular Pressure, Intracranial Pressure Increase, Trauma, Brain, Children, Only
- Trial name
- IOPICPTBI (NCT03344432)
- Testing
- with intraocular pressure high, without intraocular pressure high
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital Civil de Guadalajara
Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI)
Bioavailability of Medium Chain Triglycerides (MCTs) in Comatose Patients With Acute Brain Injury (ABI)
This study will be targeting patients suffering from acute brain injury (ABI), including those with severe trauma brain injury (sTBI) and those with aneurysmal sub arachnoid hemorrhage (aSAH).
- Conditions
- Injuries, Acute Brain, Severe Trauma Brain Injury (sTBI), Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- MCTs and ABI (NCT02716532)
- Testing
- Peptamen AF
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Société des Produits Nestlé (SPN)
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- ReBOUND (NCT07277309)
- Testing
- Low-intensity focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Mild Traumatic Brain Injury, Concussion, Mild
Facilitating Access to Specialty Treatment
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- NCT05741411
- Testing
- RPM-assisted specialist access
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Children's Hospital of Philadelphia
Traumatic Brain Injury, Acute Respiratory Failure
Intermediate Normal Versus High Normal Oxygen Levels in the Emergency Department for Severe Traumatic Brain Injury
Despite almost universal usage of supplemental oxygen therapy in patients presenting in the emergency department with traumatic brain injury (TBI), optimal oxygen levels are unclear.
- Conditions
- Traumatic Brain Injury, Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Acute Brain Injury
- Trial name
- INACHOS (NCT05464277)
- Testing
- Oxygen
- Where
- 2 sites in Greece
- Volunteers
- 1 people
- Sponsor
- Evangelismos Hospital
Traumatic Brain Injury
Copenhagen Head Injury Ciclosporin (CHIC) Study
This is an open label study on the pharmacokinetics and safety of ciclosporin in patients with severe traumatic brain injury, who require intensive care unit admission and monitoring of intracranial pressure via a ventricular…
- Trial name
- CHIC (NCT01825044)
- Testing
- NeuroSTAT 5 mg/kg/day, NeuroSTAT 10 mg/kg/day
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- NeuroVive Pharmaceutical AB
Severe Traumatic Brain Injury
Discrete Hypothermia in the Management of Traumatic Brain Injury
The primary goal of this project is to demonstrate the feasibility and clinical benefits of a new rapid treatment for secondary treatment for secondary brain injury called Discrete Cerebral Hypothermia System by CoolSystems…
- Trial name
- NCT00676104
- Testing
- CoolSystems Discrete Cerebral Hypothermia System
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Nervous System Diseases
Cost/Utility Ratio in the Management of Patients With Acquired Severe Brain Injury
The aim of this study was to compare the cost/utility ratio of a management model of integrated, graded, intensive rehabilitation (GIR) versus usual care (UC) for patients with acquired Severe Brain Injury (SBI).
- Trial name
- NCT01743261
- Testing
- multidisciplinary intervention, usual care
- Where
- Italy
- Volunteers
- 249 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cerebral Palsy, Traumatic Brain Injury
Targeted Training for Trunk Control_case Series Cerebral Palsy
If a child with cerebral palsy does not develop independent sitting balance by 4 years of age, their prognosis for walking is very poor.
- Trial name
- CP_TT (NCT02097836)
- Testing
- Targeted Training
- Volunteers
- 11 people
- Sponsor
- University of Oregon
Cerebral Stroke, Hemiplegia
Treadmill Therapy and Brain Injuries
Introduction. There is a demand for evidence whether treadmill therapy is more efficient than traditional walking training as an intervention for patients with hemiplegia after cerebral stroke. Design.
- Conditions
- Cerebral Stroke, Hemiplegia, Moderate to Severe Functional Impairments
- Trial name
- NCT01000168
- Testing
- Treadmill therapy and conventional walking therapy.
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Neurologic Disorder, Paralysis
EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis
Neuralis is an innovative assistive technology designed for individuals with severe neuromuscular conditions, enabling wheelchair control through EEG signals.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT06169696
- Testing
- Intervention/Treatment
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Synaptrix Labs Inc.
Traumatic Brain Injury
An Exploration of Sleep Disturbance and Outcomes in TBI (SLEEP-TBI)
This study aims to look at how sleep disturbance affects people who have had a traumatic brain injury. Sleep disturbance can include waking frequently in the night, difficulty falling asleep, excessive sleepiness or changes to…
- Trial name
- SLEEP-TBI (NCT07120373)
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- University of Nottingham
Terminal Illness, End-of-Life Care
Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence
Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power…
- Conditions
- Terminal Illness, End-of-Life Care, Death, Brain Death
- Trial name
- NeuroCogPresv (NCT07477028)
- Volunteers
- 20 people
- Sponsor
- Noah Tech, Corp.
Acute Ischemic Stroke
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Severe Stenosis or Occlusion of Anterior Intracranial Circulation Vessels
The primary purpose of this study is to examine whether remote ischemic treatment can better the 90 - day neurological outcomes in acute ischemic stroke patients having severe stenosis or occlusion of anterior intracranial…
- Trial name
- RICASO (NCT06823128)
- Testing
- RIC, Guideline-based therapy
- Where
- China
- Volunteers
- 458 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe
Biperiden Trial for Epilepsy Prevention
One of the most important neurological consequences following Traumatic Brain Injury (TBI) is the development of post traumatic epilepsy (PTE).
- Conditions
- Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe, Post Traumatic Epilepsy
- Trial name
- BIPERIDEN (NCT04945213)
- Testing
- Biperiden
- Where
- 10 sites in Brazil
- Volunteers
- 312 people
- Sponsor
- Hospital Sirio-Libanes
SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm
Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital
Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for…
- Conditions
- SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm, Moderate Traumatic Brain Injury, Severe Traumatic Brain Injury
- Trial name
- VASO-TC (NCT06560372)
- Testing
- Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital Center of Martinique
Traumatic Brain Injury
Cerebrospinal Fluid Endostatin/Collagen XVIII Concentrations in Patients With Severe Traumatic Brain Injury
Angiogenesis is an important pathophysiological response to traumatic brain injury (TBI) and modulated by pro- and anti-angiogenic factors.
- Trial name
- NCT01846546
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai 6th People's Hospital
Traumatic Brain Injury
GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI
The goal of this clinical trial is to evaluate GetUp\&Go, a program for promoting increased physical activity in individuals at least 6 months post moderate-to-severe traumatic brain injury.
- Trial name
- NCT06028334
- Testing
- GetUp&Go, GetUp&Go with 10-Week Delay
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Albert Einstein Healthcare Network