Clinical trials: Severe Brain Injury
Stroke, Vascular Severe Brain Injury
Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury
The rehabilitation outcome and recovery, in people after stroke or with vascular severe brain injury(vSBI), are difficult to predict.
- Conditions
- Stroke, Vascular Severe Brain Injury, Rehabilitation
- Trial name
- PRISMA (NCT06871800)
- Testing
- blood withdrawal
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Children, Adult, Spastic Cerebral Palsy
Full-spectrum Medical Cannabis for Treatment of Spasticity in Patients With Severe Forms of Cerebral Palsy
The proposed study is a double-blind, placebo-controlled, cross over study on 60 children aged 5 to 25 years with severe spasticity related to cerebral palsy (CP), level IV and V with full-spectrum medical cannabis product of…
- Conditions
- Children, Adult, Spastic Cerebral Palsy, Quality of Life, Cannabis
- Trial name
- HemPhar (NCT04634136)
- Testing
- Lab tests, ECG, Cannabinoid Levels
- Where
- 2 sites in Slovenia
- Volunteers
- 55 people
- Sponsor
- University Medical Centre Ljubljana
Trauma, Traumatic Injury
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in…
- Conditions
- Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
- Trial name
- EPO-TRAUMA (NCT04588311)
- Testing
- Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9%
- Where
- 41 sites in Australia, Belgium and 7 more
- Volunteers
- 2,500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Disorder of Consciousness, Minimally Conscious State
Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Cognitive Impairment
- Trial name
- STIMCOM (NCT03007784)
- Testing
- transcranial direct current stimulation (tDCS) / Comparison of current intensities
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Severe Traumatic Brain Injury, Gait Disorders, Neurologic
Vestibular Rehabilitation and Severe Traumatic Brain Injury
Severe brain injury (sTBI) is one of the most common causes of long-term disability and is considered the most frequent cause of mortality and serious disability in young adults in industrialized countries.
- Trial name
- NCT04415580
- Testing
- Vestibular Rehabilitation (VR), Conventional Neurorehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Disorder of Consciousness
Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness Prediction
Background: The Coma Recovery Scale-Revised (CRS-R) is the most recommended instrument to examine the neurobehavioral condition of individuals with disorders of consciousness (DOCs).
- Trial name
- CRS-R_Info (NCT05819177)
- Testing
- Rehabilitation program
- Where
- 2 sites in Spain
- Volunteers
- 171 people
- Sponsor
- Hospitales Nisa
Severe Traumatic Brain Injury
Approaches and Decisions for Acute Pediatric TBI Trial
Approaches and Decisions in Acute Pediatric TBI Trial (ADAPT) is an international research study designed to evaluate the impact of interventions on the outcomes of children with severe traumatic brain injury.
- Trial name
- ADAPT (NCT04077411)
- Testing
- Observational
- Where
- 48 sites in United States, Australia and 6 more
- Volunteers
- 1,000 people
- Sponsor
- University of Pittsburgh
Brain Injuries
Efficacy and Safety Study of Intravenous Progesterone in Patients With Severe Traumatic Brain Injury
The SyNAPSe trial will study if giving intravenous (i.v.) progesterone within 8 hours of the injury for a total of 120 hours to severe traumatic brain injury patients improves their recovery.
- Trial name
- SyNAPSe (NCT01143064)
- Testing
- Progesterone, Lipid emulsion without progesterone
- Where
- 156 sites in United States, Argentina and 19 more
- Volunteers
- 1,195 people
- Sponsor
- BHR Pharma, LLC
Traumatic Brain Injuries
Assessment of the Effects of Early Proprioceptive Stimulations in Patients With Severe Traumatic Brain Injury
"Severe traumatic brain injury (TBI) is a serious condition, common in young adults. It leads to sensorimotor and cognitive sequelae that hinder social reintegration.
- Trial name
- TC-Mouv (NCT05094999)
- Testing
- Proprioceptive stimulations
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Stroke, Hemiplegia
Treadmill Therapy and Brain Injuries
Introduction. There is a demand for evidence whether treadmill therapy is more efficient than traditional walking training as an intervention for patients with hemiplegia after cerebral stroke. Design.
- Conditions
- Cerebral Stroke, Hemiplegia, Moderate to Severe Functional Impairments
- Trial name
- NCT01000168
- Testing
- Treadmill therapy and conventional walking therapy.
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Brain Concussion, Cerebral Concussion
Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for the Emergency Department (ED)…
- Conditions
- Brain Concussion, Cerebral Concussion, Concussion, Intermediate, Concussion, Mild
- Trial name
- DETECT (NCT02776462)
- Testing
- EyeBox CNS
- Where
- 2 sites in United States
- Volunteers
- 321 people
- Sponsor
- Oculogica, Inc.
Traumatic Brain Injury
Study of Reserves After Traumatic Brain Injury
It is hypothesized that the long-term results of rehabilitation and subsequent aging after Brain Trauma depend on brain's premorbid anatomical (structural) and functional (cognitive, emotional) reserves.
- Trial name
- NCT01628003
- Testing
- Brain MRI, MRI
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cerebral Palsy, Kinesiology Taping
Short-term Effects Kinesiology Tape on Sitting Postural Control in Moderate and Severe Cerebral Palsy
To analyze the short-term effect of kinesiology taping on sitting postural control in moderate and severe cerebral palsy
- Conditions
- Cerebral Palsy, Kinesiology Taping, Postural Control
- Trial name
- KT-SIT_CP (NCT04991623)
- Testing
- Kinesiology taping, Conventional physiotherapy
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- University of Castilla-La Mancha
Brain Injury Traumatic Severe, Serum Concentrations
Electrolyte Imbalance in Surgical and Non-Surgical Geriatric Brain Injury Patients
Investigators invite you to the research titled "Evaluation of Serum Electrolyte Imbalance in Geriatric Patients Undergoing Brain Surgery: A Prospective Randomized Observational Study" conducted by Specialist Nurse Tülin KURT…
- Conditions
- Brain Injury Traumatic Severe, Serum Concentrations, Nursing, Geriatric Patients
- Trial name
- NCT07809880
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Zonguldak Bulent Ecevit University
Cerebral Palsy, Neurological Conditions
Safety and Efficacy Study of Oral Glycopyrrolate Liquid for the Treatment of Pathologic (Chronic Moderate to Severe) Drooling in Pediatric Patients 3 to 18 Years of Age With Cerebral Palsy or Other Neurologic Conditions
This is an open-label clinical research study of an oral glycopyrrolate liquid for the treatment of chronic moderate to severe drooling in patients with cerebral palsy or other neurological conditions.
- Conditions
- Cerebral Palsy, Neurological Conditions, Mental Retardation, Sialorrhea
- Trial name
- NCT00491894
- Testing
- Oral Glycopyrrolate Liquid
- Where
- 7 sites in United States
- Volunteers
- 137 people
- Sponsor
- Shionogi
Acute Brain Injury Coma, Neurocritical Care
Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring
This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help…
- Conditions
- Acute Brain Injury Coma, Neurocritical Care, Cerebral Infarction, Intracranial Hemorrhages
- Trial name
- NCT07115459
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Ictus, Severe Acquired Brain Injury
Personality Traits as a Variable in the Recovery of Patients With Acquired Brain Injury
This study aims to evaluate the potential effects of premorbid personality on the short- and long-term global cognitive recovery in patients with severe acquired brain injury (sABI) or stroke.
- Conditions
- Ictus, Severe Acquired Brain Injury, sABI
- Trial name
- NCT07119827
- Testing
- Motor, cognitive and psychological assessment
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Universita di Verona
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Euthyroid Sick Syndromes in Traumatic Brain Injury Patient and GFAP Level
Euthyroid Sick Syndrome (ESS) Effect on Traumatic Brain Injury Patients and Its Relation With GFAP Level
Euthyroid sick syndrome (ESS) effects on patients suffering from traumatic brain injury (TBI) have received little attention. Moreover, there is limited evidence that serum levels of thyroid-related hormones might influence…
- Trial name
- ESS (NCT04806672)
- Volunteers
- 50 people
- Sponsor
- Minia University
Brain Injury, Cognitive Impairment
Somatic and Ear Acupuncture for Dysphagia Rehabilitation and Decannulation After Severe Acquired Brain Injuries
The goal of this interventional, randomized, controlled, double-blind pilot study is to assess the superiority of Acupuncture and Auriculotherapy, in addition to conventional speech therapy rehabilitation, for the treatment of…
- Conditions
- Brain Injury, Cognitive Impairment, Deglutition Disorder
- Trial name
- REDACT (NCT06888219)
- Testing
- Acupuncture and Auricolotherapy, Conventional logopedic rehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS