Clinical trials: Severe Brain Injury
Disorders of Consciousness, Acquired Brain Injury
Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury
Assessment of consciousness and attention in individuals with severe Acquired Brain Injury (sABI) is crucial for planning rehabilitation, but it is often hindered by coexisting sensory-motor and/or cognitive-behavioural…
- Trial name
- SEE-ABI (NCT06464549)
- Testing
- EEG-EOG recording at rest and during an auditory oddball paradigm
- Where
- 2 sites in Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Alfonso Magliacano
Sepsis, Delirium
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Ventilated ICU patients frequently have sepsis and the majority have delirium, a form of brain dysfunction that is an independent predictor of increased risk of dying, length of stay, costs, and prolonged cognitive impairment in…
- Conditions
- Sepsis, Delirium, Impaired Cognition
- Trial name
- MENDS2 (NCT01739933)
- Testing
- Dexmedetomidine, Propofol
- Where
- 11 sites in United States
- Volunteers
- 438 people
- Sponsor
- Vanderbilt University Medical Center
Brain Injuries
The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury
This is a multi-centre randomised trial to evaluate the effect of early decompressive craniectomy on neurological function in patients with severe traumatic brain injury.
- Trial name
- NCT00155987
- Testing
- Early decompressive craniectomy
- Where
- Australia
- Volunteers
- 155 people
- Sponsor
- National Trauma Research Institute
Traumatic Brain Injury, Depression
Life Improvement Following Traumatic Brain Injury
The purpose of this study is to test the effectiveness of a telephone-based and in-person Cognitive Behavioral Therapy (CBT) intervention for treating Major Depressive Disorder (MDD) following Traumatic Brain Injury.
- Trial name
- LIFT (NCT00878150)
- Testing
- In-person Cognitive Behavioral Therapy, Telephone Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Traumatic Brain Injury
ICP Threshold After Decompressive Craniectomy
Severe traumatic brain injury (sTBI) is a critical disease of public health importance. Increased intracranial play a significant role in the secondary injury of TBI. Reducing the ICP is helpful in reducing the mortality of sTBI.
- Trial name
- NCT06083792
- Volunteers
- 240 people
- Sponsor
- Tang-Du Hospital
Tramatic Brain Injury
Evaluating Near-infrared Spectroscopy Devices for Monitoring Traumatic Brain Injury
This project seeks to evaluate the capabilities of new Near Infrared Spectroscopy (NIRS) devices, which use light to measure brain activity, for monitoring how the brain and body react after a serious head injury (TBI)…
- Trial name
- NIRS in TBI (NCT07106216)
- Volunteers
- 10 people
- Sponsor
- University of Cambridge
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Acquired Brain Injury Including Stroke
Evaluating a CFT Group for Adults With Acquired Brain Injury
Emotional difficulties such as anxiety and depression are common after experiencing a brain injury. The compassion focused therapy (or CFT) model proposes the importance of developing skills in being able to self-soothe and be…
- Trial name
- NCT06316258
- Testing
- Compassion focused therapy group
- Volunteers
- 12 people
- Sponsor
- King's College London
Brain Injuries, Hypothermia
Hypothermia to Treat Severe Brain Injury
The purpose of this trial is to determine if hypothermia (body cooling), administered very soon after a severe brain injury improves functional outcome. This pilot trial ended in July 2005.
- Trial name
- NCT00040339
- Testing
- hypothermia (body temperature lowered to 33°C or 91.4°F)
- Where
- 5 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
TBI (Traumatic Brain Injury)
Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial
BioBOOST is a multicenter, observational study of the effect of derangements in brain physiologic parameters on brain injury biomarker levels in patients with severe traumatic brain injury.
- Trial name
- BioBOOST (NCT04565119)
- Testing
- No intervention. This is an observational study.
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Pennsylvania
Head Trauma, Subarachnoid Hemorrhage
Problems With Morphine Use in Patients With a Severe Brain Injury
Hypothesis: During severe brain trauma (injury, surgery) the ensuing inflammatory response in the central nervous system (CNS) results in a decrease in the expression of the transporter protein p-glycoprotein (PGP) in the blood…
- Conditions
- Head Trauma, Subarachnoid Hemorrhage, Close Head Injury
- Trial name
- NCT00196131
- Testing
- morphine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Dalhousie University
SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm
Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital
Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for…
- Conditions
- SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm, Moderate Traumatic Brain Injury, Severe Traumatic Brain Injury
- Trial name
- VASO-TC (NCT06560372)
- Testing
- Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital Center of Martinique
Tracheostomy Decannulation, Acquired Brain Injury
Comparison of the Decannulation Protocol With Suctioning and Capping in Severe Acquired Brain Injury Patients
Single-center randomized trail focused on tracheostomized patients with severe acquired brain injury , comparing two different decannulation protocols: 1.
- Trial name
- NCT04835272
- Testing
- the Decannulation Protocol With Suctioning
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Traumatic Brain Injury
Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury
The goal of this clinical trial is to test the safety of the drug Angiotensin (1-7) and learn whether it works well as a treatment in people who have suffered a moderate to severe traumatic brain injury (TBI).
- Trial name
- ANGel T (NCT06282965)
- Testing
- Angiotensin (1-7), Sterile saline
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Critically Ill Patients, Cardiac Surgery
Impact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) Outcome
Critically ill patients are generally exposed to an increased oxidative stress, which is proportional to the severity of their condition.
- Conditions
- Critically Ill Patients, Cardiac Surgery, Trauma, Subarachnoid Hemorrhage
- Trial name
- Etude-AOX (NCT00515736)
- Testing
- Selenium (Se), Zinc (Zn), Vitamin C, Vitamin B1, Vitamin E
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Traumatic Brain Injury
Efficacy of Ketamine in Children With Severe Brain Injury for Brain Cell Protection
The purpose of this study is to determine the possible effects of an anesthetic agent called Ketamine on the injured brain in children. The researchers think that it will effect the outcomes of children with these injuries.
- Trial name
- NCT00556387
- Testing
- saline, Ketamine
- Sponsor
- University of Arkansas
Self-management, Feasibility Studies
Self-management Program for Patients in the Sub-acute Phase After Traumatic Injury - a Feasibility Study
The goal of this descriptive non-randomized feasibility study is to assess aspects of feasibility of the intervention arm in a planned full-scale randomized controlled trial testing the effectiveness of a self-management program…
- Conditions
- Self-management, Feasibility Studies, Spinal Cord Injuries, Brain Injuries
- Trial name
- SMS_trauma (NCT06093074)
- Testing
- self-management program after traumatic injuries
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Oslo University Hospital
Brain Injury Traumatic Severe, Intracranial Hemorrhage, Hypertensive
Multiomic Analysis of Traumatic Brain Injury and Hypertension Intracranial Hemorrhage Lesion Tissue
The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients.
- Trial name
- MOSS-THINK (NCT05778110)
- Testing
- Type of disease
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Brain Injuries, Traumatic
Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)
The purpose of this study is to determine if hypertonic saline with and without dextran can improve neurologic outcomes in victims of severe traumatic brain injury (TBI).
- Trial name
- NCT00316004
- Testing
- 7.5% Hypertonic Saline in 6% Dextran-70 (HSD), 7.5% Hypertonic Saline (HS), 0.9% Normal Saline (NS)
- Where
- 12 sites in United States, Canada
- Volunteers
- 1,331 people
- Sponsor
- University of Washington
Brain Injuries
Early Mobilisation After Severe Traumatic Brain Injury
Increasing focus on the negative effects of bed rest have become more apparent in the intensive care unit within the last decade.
- Trial name
- NCT02924649
- Testing
- Early Intensive mobilisation
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet