Clinical trials: Severe Brain Injury
Traumatic Brain Injury, Concussion, Intermediate
Intervention to Change Affect Recognition and Empathy
Determine the feasibility, practicality, and early efficacy of a TeleRehab program (ICARE) to improve outcomes for persons with traumatic brain injury (TBI) in recognizing and responding to others' emotions alongside their care…
- Conditions
- Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes
- Trial name
- ICARE (NCT05636020)
- Testing
- ICARE Treatment
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Indiana University
Post Traumatic Stress Disorder PTSD, Major Depressive Disorder (MDD)
Accelerated iTBS for PTSD and Depression
The goal of this pilot clinical trial is to learn if a faster brain stimulation schedule is practical, safe, tolerable, and acceptable. This study looks at accelerated intermittent theta burst stimulation, or accelerated iTBS.
- Trial name
- NCT07682207
- Testing
- Accelerated intermittent theta burst stimulation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Lawson Research Institute of St. Joseph's
Trauma, Traumatic Injury
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in…
- Conditions
- Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
- Trial name
- EPO-TRAUMA (NCT04588311)
- Testing
- Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9%
- Where
- 41 sites in Australia, Belgium and 7 more
- Volunteers
- 2,500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Brain Injuries, Traumatic, Concussion, Brain
Objective Brain Function Assessment of mTBI/Concussion in High School Athletes
This study (Part 2) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Concussion, Mild, Concussion, Intermediate
- Trial name
- AheadCAS-HS (NCT02661633)
- Testing
- BrainScope Ahead 200iD, Advanced MRI Neuroimaging
- Where
- 4 sites in United States
- Volunteers
- 177 people
- Sponsor
- BrainScope Company, Inc.
Severe Traumatic Brain Injury
The Systemic Nature of Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a devastating condition with no targeted therapies available to prevent secondary injury.
- Trial name
- MANTRA (NCT07679126)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Corewell Health West
Traumatic Brain Injury
Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State
A randomised control trial of patients who have a severe brain injury to determine if patients who receive a standardised sensory stimulation program emerge earlier from a vegetative state.
- Trial name
- NCT00163878
- Testing
- Sensory Stimulation, Sesnory Modality Assessment and Rehabilitation Technique
- Where
- 2 sites in Australia
- Sponsor
- Bayside Health
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Chronic Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study
The purpose of this feasibility clinical investigation is to evaluate the safety and usability of central thalamic deep brain stimulation (CT-DBS) for use in patients with chronic moderate to severe traumatic brain injury (TBI)…
- Trial name
- NCT07730099
- Testing
- Deep brain stimulation
- Volunteers
- 40 people
- Sponsor
- ReEmerge, Inc.
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
Brain Injury Traumatic Severe, Disorder of Consciousness
Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness
This study first aims to validate the feasibility of a multimodal 5-day 20-minute tACS protocol in subacute brain-injured patients with a disorder of consciousness during their ICU stay, and conduct a clinical pilot study…
- Conditions
- Brain Injury Traumatic Severe, Disorder of Consciousness, Brain Injuries
- Trial name
- NCT05833568
- Testing
- Active Transcranial alternative current stimulation
- Volunteers
- 138 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Acquired Brain Injury Including Stroke
Evaluating a CFT Group for Adults With Acquired Brain Injury
Emotional difficulties such as anxiety and depression are common after experiencing a brain injury. The compassion focused therapy (or CFT) model proposes the importance of developing skills in being able to self-soothe and be…
- Trial name
- NCT06316258
- Testing
- Compassion focused therapy group
- Volunteers
- 12 people
- Sponsor
- King's College London
TBI (Traumatic Brain Injury)
Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial
BioBOOST is a multicenter, observational study of the effect of derangements in brain physiologic parameters on brain injury biomarker levels in patients with severe traumatic brain injury.
- Trial name
- BioBOOST (NCT04565119)
- Testing
- No intervention. This is an observational study.
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Pennsylvania
Autism Spectrum Disorder, Traumatic Brain Injury
Using Virtual Reality and Robotics Technologies for Vocational Evaluation, Training and Placement
Using Virtual Reality and Robotics Technologies for Vocational Evaluation, Training and Placement (VR4VR) is a project that incorporates Virtual Reality into job training to increase job opportunities for people who have physical…
- Trial name
- VR4VR (NCT02498262)
- Testing
- Virtual Reality System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Brain Injuries
Mobility and Activity Patterns in Hospitalised Severe Brain Injury
The purpose of this observational study is to quantify physical activity patterns in patients with severe acquired brain injury admitted for in-hospital rehabilitation.
- Trial name
- MAP-ABI (NCT05571462)
- Testing
- Activity monitor group
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Christian Riberholt
Traumatic Brain Injury, Severe Traumatic Brain Injury
Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial
The LIMIT-TBI trial is a multicenter, international, randomized, phase II clinical trial designed to evaluate the feasibility and safety of targeting a neutral fluid balance compared to standard care in critically ill adult…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Acute Brain Injury, Neurocritical Care
- Trial name
- LIMIT-TBI (NCT07625995)
- Testing
- Neutral Fluid Balance Strategy
- Where
- 3 sites in Belgium, Italy
- Volunteers
- 88 people
- Sponsor
- Erasme University Hospital
Concussion, Mild, Concussion; Eye
EYE-SYNC Concussion Classification Study
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for sport-related concussion…
- Conditions
- Concussion, Mild, Concussion; Eye, Concussion, Brain, Concussion, Severe
- Trial name
- NCT04381767
- Testing
- EYE-SYNC
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- Sync-Think, Inc.
Disorders of Consciousness
Intensive Neurowave Emotional Stimulation (INES)
This is a randomized and controlled pilot study investigating the effects of intensive emotional stimulation with neurological waves (INES) on cognitive-motor functions in patients diagnosed with Vegetative State (VS) and…
- Trial name
- INES_ABI (NCT06204172)
- Testing
- Intensive Neurowave Emotional Stimulation (INES), Intensive Sensorial Emotional Stimulation (ISES)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Traumatic Brain Injury
Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patient
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- IOE-TBI (NCT06261281)
- Testing
- Rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
- Where
- China
- Sponsor
- Zeng Changhao
Brain Injuries, Traumatic, Brain Injury Traumatic Severe
Online Memory Intervention for Individuals with Traumatic Brain Injury
This study will examine the behavioural and neurophysiological efficacy and feasibility of an online spatial navigation intervention for improving memory and brain health in individuals who have sustained moderate-severe…
- Conditions
- Brain Injuries, Traumatic, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, Brain Injury, Chronic
- Trial name
- NCT04331392
- Testing
- Spatial Navigation Intervention, Educational Videos
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Toronto Rehabilitation Institute
Traumatic Brain Injury
ICP Threshold After Decompressive Craniectomy
Severe traumatic brain injury (sTBI) is a critical disease of public health importance. Increased intracranial play a significant role in the secondary injury of TBI. Reducing the ICP is helpful in reducing the mortality of sTBI.
- Trial name
- NCT06083792
- Volunteers
- 240 people
- Sponsor
- Tang-Du Hospital