Clinical trials: Severe Infection
COVID-19, SARS-CoV 2
EXercise TRAining and Sedentary Lifestyle on Clinical Outcomes in Patients With COVID-19
The present study aims to assess the impact of exercise training, physical activity, and sedentary lifestyle on clinical outcomes in surviving patients infected with the severe acute respiratory syndrome coronavirus 2…
- Conditions
- COVID-19, SARS-CoV 2, Corona Virus Infection, Sedentary Behavior
- Trial name
- WHO (NCT04396353)
- Testing
- Electronic questionnaire
- Where
- Brazil
- Volunteers
- 1,574 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
RSV Infection, Bronchiolitis
Severity of RSV Infections in Twins
Respiratory syncytial virus (RSV) infection is the most common cause of severe lower respiratory tract infection (LRTI) in the pediatric population worldwide.
- Trial name
- TwinSeVeRS (NCT05070975)
- Testing
- Epidemiology
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Hospices Civils de Lyon
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Immunologic Diagnostic Blood Test in Predicting Side-Effects in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer or Other Diseases
RATIONALE: Studying a diagnostic biomarker test in blood samples from patients who have undergone a donor stem cell transplant for cancer may help doctors plan treatment.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Infection, Leukemia
- Trial name
- NCT00813501
- Testing
- immunosuppressive therapy, immunological diagnostic method, allogeneic hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- City of Hope Medical Center
Respiratory Syncytial Virus Infection, Premature Birth
Palivizumab for Prevention of Severe Respiratory Syncytial Virus Infection in Russian Children
100 Russian children of 2 years of age and less in high-risk populations (preterm, and/or with heart and lung problems) will receive palivizumab (Synagis) 15 mg/kg intramuscularly as prophylaxis to severe respiratory syncytial…
- Conditions
- Respiratory Syncytial Virus Infection, Premature Birth, Bronchopulmonary Dysplasia, Congenital Heart Disease
- Trial name
- NCT01006629
- Testing
- palivizumab
- Where
- 19 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Abbott
Burkitt Lymphoma, Lymphoma, Large-Cell, Diffuse
Pilot Protocol for the Treatment of Patients With Small Non-Cleaved and Diffuse Large Cell Lymphomas
Major improvements in the treatment of childhood non-lymphoblastic lymphomas have taken place in the last ten years. Though the survival rate in low risk patients (i.e., those with stage I \& II disease and serum LDH of less than…
- Conditions
- Burkitt Lymphoma, Lymphoma, Large-Cell, Diffuse, Lymphoma, Small Noncleaved-Cell
- Trial name
- NCT00001237
- Testing
- granulocyte-macrophage colony stimulating factor (GM-CSF)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
SARS-CoV Infection
Serological Diagnostics of COVID-19 in Health Care Workers
All health care workers at the Department of Anesthesiology and Intensive Care at UMC Ljubljana will be tested for SARS-CoV2 with nasal swab test and blood withdrawal for SARS-CoV2 antibodies.
- Trial name
- KORANIT (NCT04635592)
- Testing
- SARS-CoV2 nasal swab
- Where
- Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
COVID-19 Infection
Study of Hemostasis in Case of Severe COVID-19
The COVID-19 outbreak has led to a significant increase in the number of patients admitted to intensive care for respiratory distress.
- Trial name
- THROMBOVID (NCT04359992)
- Testing
- Extra blood sample
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Myeloproliferative Disorders, Leukemia
Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and busulfan, before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- Bu Flu TBI (NCT00245037)
- Testing
- therapeutic allogeneic lymphocytes, busulfan, cyclosporine
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- OHSU Knight Cancer Institute
Myasthenia Gravis, Guillain-Barre Syndrome
Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis
Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols.
- Trial name
- GUIMAUVE (NCT07022028)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Poitiers University Hospital
Cystic Fibrosis (CF), Cystic Fibrosis Pulmonary Exacerbation
Understanding Inflammation, InFection and Interventions in Severe Exacerbations of Cystic Fibrosis
The UNIFIED-CF study is an observational study designed to investigate the impacts of treatment given for severe pulmonary exacerbations in people living with cystic fibrosis (pwCF).
- Trial name
- UNIFIED-CF (NCT07484607)
- Where
- 6 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Alexander Horsley
Long COVID, Major Depressive Disorder
Presynaptic Imaging in Major Depressive Episodes After COVID-19
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP).
- Conditions
- Long COVID, Major Depressive Disorder, Major Depressive Episode
- Trial name
- PCOV (NCT06086366)
- Testing
- [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Hidradenitis Suppurativa
Real-world Secukinumab Outcomes in Canadian HS Patients
The HS-RISE study aims to assess real-world HS treatment outcomes and patterns, safety of secukinumab, and to describe the baseline characteristics of patients diagnosed with moderate-to- severe HS who are prescribed secukinumab…
- Trial name
- HS-RISE (NCT07282015)
- Where
- 15 sites in Canada
- Volunteers
- 142 people
- Sponsor
- Novartis Pharmaceuticals
Covid19, Infertility, Male
Impact of the Coronavirus Disease 2019 (COVID-19) on Sperm Parameters
This study aims to better understand the effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, virus that causes the coronavirus disease 2019 (COVID-19), on male fertility.
- Trial name
- NCT04937608
- Testing
- Sperm analysis
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Fertilys
COVID-19 Infection
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
This is a Phase 3, randomized, actively controlled, double-blinded, double-dummy, superiority study to evaluate the efficacy and safety of ibuzatrelvir alone and in combination with remdesivir IV compared to remdesivir IV alone…
- Trial name
- NCT07013474
- Testing
- ibuzatrelvir, remdesivir
- Where
- 159 sites in United States, Argentina and 16 more
- Volunteers
- 300 people
- Sponsor
- Pfizer
COVID-19, SARS-CoV 2
CONVALESCENT PLASMA FOR ILL PATIENTS BY COVID-19
The present study will try to respond first in an initial phase, what is the minimum effective dose necessary of convalescent plasma for getting better in severly ill (not intubated) or very severely ill (intubated) patients.
- Conditions
- COVID-19, SARS-CoV 2, Convalescence, Plasma
- Trial name
- COPLASCOV19 (NCT04356482)
- Testing
- convalescent plasma
- Where
- 3 sites in Mexico
- Volunteers
- 90 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
COVID-19 Prevention
Clinical Trial to Assess Safety and Immunogenicity of Gam-COVID-Vac Combined Vector Vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Сov-2) Infection
Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Centre Phase II/III Adaptive Clinical Trial to Assess the Safety and Immunogenicity of Gam-COVID-Vac Combined Vector Vaccine for SARS-Сov-2 Infection in Indian…
- Trial name
- NCT04640233
- Testing
- Gam-COVID-Vac
- Where
- 23 sites in India
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Sepsis, Shock
The Effect of Erythropietin on Microcircualtory Alteration in Intensive Care Unit Patients With Severe Sepsis
The objective of this study is to determine if observations the investigators made in an animal model of sepsis can be translated to clinical practice.
- Trial name
- NCT01087450
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- London Health Sciences Centre
Lymphoma
Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Disease
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with allogeneic or autologous peripheral stem cell transplantation may allow the…
- Trial name
- CBV (NCT00005613)
- Testing
- cyclophosphamide, etoposide, BCNU
- Where
- 2 sites in United States
- Volunteers
- 147 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Cancer, Leukemia
Phase I/II Study of Escalating-Dose Melphalan w/Autologous SCS & Amifostine Cytoprotect
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Neuroblastoma
- Trial name
- NCT00003425
- Testing
- filgrastim, amifostine trihydrate, cyclophosphamide
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Kentucky