Clinical trials: Severe Infection
Gastric Cancer, Gastric (Stomach) Cancer
Gastric Cancer Endoscopic Screening in an Intermediate-risk Country - ROGCAS, a Dual-centre Pilot Program
Endoscopic screening of gastric cancer combined with screening colonoscopy
- Conditions
- Gastric Cancer, Gastric (Stomach) Cancer, Atrophic Gastritis, Intestinal Metaplasia of Gastric Mucosa
- Trial name
- ROGCAS (NCT06316882)
- Testing
- Screening endoscopy
- Where
- Portugal
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Unidade Local De Saúde Do Norte Alentejano
Covid19, Vitamin D Deficiency
High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study
The world is currently facing a pandemic with the coronavirus (SARS-CoV-2) which leads to the disease of COVID-19. Risk factors for a poor outcome of COVID-19 have so far been identified as older age and co-morbidity including…
- Conditions
- Covid19, Vitamin D Deficiency, Corona Virus Infection, ARDS
- Trial name
- VitCov (NCT04525820)
- Testing
- Single high dose vitamin D, Treatment as usual vitamin D
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Prof. Dr. Jörg Leuppi
COVID-19
Tocilizumab for Prevention of Respiratory Failure in Patients With Severe COVID-19 Infection
The purpose of this study is to find out whether the study drug tocilizumab is an effective treatment for COVID-19 infection.
- Trial name
- NCT04377659
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sepsis, Severe Sepsis
ED Tracking Sheet Implementation
The purpose of this study is to assess whether implementation of an ED Sepsis Tracking Sheet effects the percentage of goal-directed sepsis criteria met in a tertiary care academic Emergency Department.
- Conditions
- Sepsis, Severe Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT05213923
- Testing
- ED Sepsis Tracking Sheet
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Vulvovaginal Candidiasis
MGCD290 and Fluconazole Versus Fluconazole Alone for the Treatment of Moderate to Severe Vulvovaginal Candidiasis
The primary objective of the study is to evaluate the rate of therapeutic cure of the combination treatment of MGCD290 and fluconazole as compared to that of fluconazole alone at Test of Cure Visit for patients with moderate to…
- Trial name
- NCT01497223
- Testing
- MGCD290
- Where
- 19 sites in United States
- Volunteers
- 220 people
- Sponsor
- MethylGene Inc.
Pneumonia, Hypoxaemia
Use of Bubble Continuous Positive Airway Pressure Compared to Nasal Prong Oxygen or Humidified High Flow in Children Under Five With Severe Pneumonia and Hypoxaemia
Continuous Positive Airway Pressure (CPAP) is a common form of support for patients admitted to Intensive Care Units (ICUs) of industrialized countries with respiratory distress (1).
- Trial name
- NCT01396759
- Testing
- Bubble continuous positive airway pressure, Humidified high flow air / O2 mix at 2 l/kg/min, Standard O2 supplementation by nasal cannula at 0.5 - 2 l/min
- Where
- Bangladesh
- Volunteers
- 975 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Infection Systemic
Prognostic Value of Complete Blood Count in Severe Infections
Sepsis is a leading cause of hospitalization in pediatric intensive care units, In the last decade, a series of initiatives were implemented that aim not only to improve the understanding of sepsis and the clarity of concepts…
- Trial name
- NCT03685071
- Testing
- role of CBC as prognostic tool in sepsis.
- Volunteers
- 100 people
- Sponsor
- Assiut University
Respiration, Artificial, COVID-19
Healthcare-associated Infections in Severe COVID-19 During 2020
In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2.
- Conditions
- Respiration, Artificial, COVID-19, Health Care Associated Infection
- Trial name
- COVIACS (NCT04819165)
- Testing
- COVID-19
- Where
- Argentina
- Volunteers
- 252 people
- Sponsor
- Sanatorio Anchorena San Martin
COVID-19
Utilizing the Crosstalk Among Aerosolized Phenformin , Methylene Blue, Photodynamic Therapy , Zinc and Potassium for Treating Severe COVID-19 Infection and Its Inflammatory Complication
Utilizing the crosstalk among aerosolized phenformin, methylene blue, photodynamic therapy , zinc and potassium for treating severe COVID-19 infection and its inflammatory complication Amr Ahmed(1), Mahmoud Elkazzaz(2), Tamer…
- Trial name
- NCT05003492
- Testing
- Combination therapy plus Standard therapy, Photodynamic therapy, Standard therapy
- Where
- Saudi Arabia
- Volunteers
- 2 people
- Sponsor
- Amr kamel khalil Ahmed
AIDS-Related Anal Carcinoma, AIDS-Related Cervical Carcinoma
Screening Algorithms for Cervical and Anal High-Grade Squamous Intraepithelial Lesions in People With HIV in Mexico and Puerto Rico
This clinical trial aims to find what different tests work best to find high-grade squamous intraepithelial lesions (HSIL) in the cervix or anus in patients living with human immunodeficiency virus (HIV).
- Conditions
- AIDS-Related Anal Carcinoma, AIDS-Related Cervical Carcinoma, High Grade Anal Intraepithelial Neoplasia, High Grade Cervical Intraepithelial Neoplasia
- Trial name
- CAMPO-101 (NCT05074264)
- Testing
- Biopsy, Biospecimen Collection - Anal, Biospecimen Collection - Cervical
- Where
- 4 sites in Mexico, Puerto Rico
- Volunteers
- 1,586 people
- Sponsor
- University of California, San Francisco
Covid19
Study To antagOnize Plasminogen Activator Inhibitor-1 in Severe COVID-19
This is a single-center, randomized double blind placebo controlled trial to evaluate the efficacy and safety of novel PAI-1 inhibitor (TM5614) for high-risk patients hospitalized with severe COVID-19 at Northwestern Memorial…
- Trial name
- NCT04634799
- Testing
- TM5614
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwestern University
Coronavirus Covid-19 Infection Variant Omicron, SARS (Severe Acute Respiratory Syndrome)
Nitric Oxide Gas Inhalation for Severe Acute Respiratory Syndrome in COVID-19.
The investigators will enroll 104 patients with severe COVID-19 infection that mechanical ventilation is needed for respiratory support.
- Trial name
- NOSARSCOVID (NCT04290871)
- Testing
- Nitric Oxide Gas, The delivery system will be set up anyway without study gas administration
- Sponsor
- Xijing Hospital
COVID-19
SARS-CoV-2 Antibodies Based IVIG Therapy for COVID-19 Patients
Severe and critically ill patients will be enrolled in the study (50 patients) after duly filled consent forms. Recipients shall be divided in to 5 groups with 10 patients per group to compare clinical efficacy and safety of…
- Trial name
- NCT04521309
- Testing
- SARS-CoV-2 antibody based IVIG therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Dow University of Health Sciences
COVID-19
A Study to Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus Disease 2019 (COVID-19) Patients
The primary purpose of Stage-I of this study is to evaluate the safety and tolerability of OP-101 in patients with severe COVID-19 and of Stage 2 of this study is to evaluate the efficacy of OP-101 in patients with severe…
- Trial name
- PRANA (NCT04458298)
- Testing
- OP-101
- Where
- 8 sites in United States
- Volunteers
- 28 people
- Sponsor
- Ashvattha Therapeutics, Inc.
Covid19, SARS-CoV Infection
Tenofovir-DF Versus Hydroxychloroquine in the Treatment of Hospitalized Patients With COVID-19 (TEDHICOV)
Although several therapeutic agents have been suggested for the treatment of the disease caused by the Coronavirus of the year 2019 (COVID-19), no antiviral has yet demonstrated consistent efficacy.
- Conditions
- Covid19, SARS-CoV Infection, Tenofovir
- Trial name
- TEDHICOV (NCT04812496)
- Where
- Peru
- Volunteers
- 100 people
- Sponsor
- Hospital Nacional Carlos Alberto Seguin Escobedo - EsSalud
COVID-19
RCT for Yinqiaosan-Maxingganshitang in the Treatment of COVID-19
This is a randomized, double-blinded, placebo-controlled clinical trial. This study is to evaluate the effectiveness and safety of Yinqiaosan-Maxingganshitang in the treatment of the major symptoms of mild and moderate COVID-19…
- Trial name
- NCT05787327
- Testing
- Chinese Herb
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- Chinese University of Hong Kong
Graft Versus Host Disease, Leukemia
Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Myelodysplastic Syndromes
- Trial name
- NCT00003661
- Testing
- anti-thymocyte globulin, busulfan, cyclosporine
- Where
- 17 sites in United States
- Volunteers
- 3 people
- Sponsor
- Roswell Park Cancer Institute
ABPA, Severe Asthma
Benralizumab in the Treatment of Patients With Severe Asthma With ABPA
Phase IV, open-label study will evaluate effects of Benralizumab in the treatment of severe asthma in patients with allergic bronchopulmonary aspergillosis
- Conditions
- ABPA, Severe Asthma, Allergic Bronchopulmonary Aspergillosis
- Trial name
- NCT04108962
- Testing
- Fasenra, 30 Mg/mL Subcutaneous Solution
- Where
- United States
- Sponsor
- Baylor Research Institute
SARS-CoV Infection, Coronavirus
Should Palatine Tonsils be Included in the Oropharyngeal Swab for SARS-CoV-2 Molecular Testing?
Citizens who undergo testing for COVID-19 at one of two Testcenters in Copenhagen Captial Region will be invited to participate in the study.
- Conditions
- SARS-CoV Infection, Coronavirus, Corona Virus Infection
- Trial name
- NCT05611203
- Testing
- An Oropharyngeal swab
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)