Clinical trials: Severe Knee Osteoarthritis
Osteoarthritis, Knee, Osteoarthritis, Hip
To Assess the Patients' Ability to Self-Administer Fasinumab
The primary objective is to demonstrate that the auto-injector(AI) is suitable to be used to administer fasinumab at home by patients or their caregivers, as measured by collecting 12 weeks of actual-use data on the technical…
- Trial name
- FACT DEVICE (NCT03491904)
- Testing
- Fasinumab AI, Fasinumab PFS
- Where
- 23 sites in United States
- Volunteers
- 100 people
- Sponsor
- Regeneron Pharmaceuticals
Hip Osteoarthritis, Knee Osteoarthritis
What Matters to Patients With Severe Hip or Knee Osteoarthritis?
This clinical trial aims to investigate if shared decision-making, and the use of an in-consultation patient decision aid (PtDA), increases the decisional quality and therefore treatment satisfaction and outcome of patients with…
- Trial name
- PATI-Project (NCT05972525)
- Testing
- Shared decision-making supported by an in-consultation PtDA to patients with severe osteoarthritis in their hip or knee
- Where
- 3 sites in Denmark
- Volunteers
- 615 people
- Sponsor
- Vejle Hospital
Knee Osteoarthritis
High Frequency Intensive Autologous PRP Injection and Genicular Nerve Blocks in Treating Knee Osteoarthritis
Osteoarthritis (OA) of the knees is the most common degenerative disorder seen in a rehabilitation outpatient clinic. It is characterized by structural changes in the articular cartilage and the surrounding tissues.
- Trial name
- NCT04088045
- Testing
- Autologous platelet rich plasma and 5% dextrose solution injections.
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Knee, Osteoarthritis, Hip
BMAC in Severe Hip or Knee Osteoarthritis Awaiting Arthroplasty
The prevalence of severe and disabling osteoarthritis of the hip and/or knee in Albertans is high and increasing. Existing nonsurgical treatments often inadequately control symptoms.
- Trial name
- NCT03908827
- Testing
- Bone Mineral Aspirate Concentrate (BMAC)
- Where
- Canada
- Sponsor
- CAPRI Clinic
Osteoarthritis (OA) of the Knee
53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee
53-Week Study Evaluating the Safety and Efficacy of Intra-articular (IA) Injections of TPX-100 vs Placebo in Subjects with Mild to Severe Tibio-Femoral Osteoarthritis of the Knee
- Trial name
- NCT06865079
- Testing
- TPX-100 200mg, Once weekly for 4 weeks, PBS
- Where
- 33 sites in United States
- Volunteers
- 270 people
- Sponsor
- OrthoTrophix, Inc
Knee Osteoarthritis, Knee Pain Chronic
Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA
It is hypothesized that a single Intra-articular Injection of TTAX03, 100mg in 2mL of saline, will have more benefit with respect to the proportion of responders 12 weeks post-injection than an equal volume of saline, based on…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT05079035
- Testing
- TTAX03, Saline
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- BioTissue Holdings, Inc
Degenerative Osteoarthritis, Rheumatoid Arthritis
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
Prospective, multinational pilot study for evaluation of the Pheno4U data platform in Total Knee Arthroplasty (TKA) patients
- Conditions
- Degenerative Osteoarthritis, Rheumatoid Arthritis, Posttraumatic Arthropathy, Chronic Instability of Knee
- Trial name
- Pheno4U Pilot (NCT05302934)
- Testing
- Pheno4U
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 600 people
- Sponsor
- Aesculap AG
Knee Osteoarthritis
A Study of Single and Repeat Dose Administration of UBX0101 in Patients With Osteoarthritis of the Knee
A study to assess safety, tolerability and clinical effects of single and repeat dose intra-articular administration of UBX0101 in patients with moderate to severe painful knee osteoarthritis (OA).
- Trial name
- NCT04229225
- Testing
- UBX0101
- Where
- 7 sites in United States
- Volunteers
- 35 people
- Sponsor
- Unity Biotechnology, Inc.
Osteoarthritis, Knee, Genu Varum
Adductor Ratio in Severe Varus Gonarthrosis
The restoration of the joint line (JL) is essential for the proper functioning of Total Knee Arthroplasty (TKA). The exact position of JL can be determined using anatomical landmarks such as femoral condylar width (TEW), tibial…
- Conditions
- Osteoarthritis, Knee, Genu Varum, Joint Prosthesis; Complications
- Trial name
- NCT05936814
- Testing
- total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Saglik Bilimleri Universitesi
Pain, Nausea
A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip
The purpose of CLCT-006, a multi-center open-label study, is to evaluate the safety of CL-108 (hydrocodone 7.5 mg/APAP 325 mg, promethazine 12.5 mg) for the treatment of moderate to severe acute pain ("flare") associated with…
- Conditions
- Pain, Nausea, Vomiting
- Trial name
- NCT02462850
- Testing
- CL-108
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Charleston Laboratories, Inc
Osteoarthritis of Knee
Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
Primary aim: evaluate efficacy of intra-articular injection of etanercept for moderate and severe knee osteoarthritis. Second aim: investigate the potentiality of serum cytokines (TNF-α, Interleukin 1-α (IL1-α), IL1-β, matrix…
- Trial name
- EIAIETNKOA (NCT02722772)
- Testing
- Etanercept, Health education, exercise and diet guidance
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Post-traumatic Osteoarthritis
A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis
With IRB approval and informed consent, patients (n=10) (18-50 years old) with post-traumatic knee OA and requiring a tibial plateau and meniscus arthroplasty plus a femoral condyle arthroplasty will be enrolled in the study.
- Trial name
- NCT03257371
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James Stannard
Osteoarthritis, Knee, Pain, Knee
Study of Resiniferatoxin for Knee Pain in Moderate to Severe Osteoarthritis
This study evaluates the safety of resiniferatoxin in patients with moderate to severe knee pain due to osteoarthritis.
- Trial name
- NCT03542838
- Testing
- Resiniferatoxin, Saline
- Where
- 4 sites in United States
- Volunteers
- 94 people
- Sponsor
- Sorrento Therapeutics, Inc.
Osteoarthritis, Osteoarthritis, Hip
A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain
The purpose of this study is to compare the safety and effectiveness of different doses of JNJ-42160443 with placebo in the treatment of chronic, moderate to severe knee or hip pain in patients with a diagnosis of osteoarthritis.
- Conditions
- Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Pain
- Trial name
- NCT00973141
- Testing
- JNJ-42160443
- Where
- 77 sites in United States, Canada and 2 more
- Volunteers
- 467 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis, Knee, Knee Osteoarthritis
Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis
This study evaluates the efficacy and safety of a single IA injection of various RTX doses, Zilretta or placebo for the treatment of pain due to moderate to severe osteoarthritis knee pain..
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NCT04885972
- Testing
- Resiniferatoxin, Zilretta
- Where
- 6 sites in United States
- Volunteers
- 124 people
- Sponsor
- Sorrento Therapeutics, Inc.
Knee Osteoarthritis
Open Versus Close Chain Exercise Effects With Lifestyle Modification and Education in Knee Osteoarthritis
A randomized clinical trial will be conducted in Gujranwala and 24 patients with grade 3 knee OA will be recruited. After consent, patients will be randomly allocated into 2 groups by lottery method.
- Trial name
- NCT05877703
- Testing
- close kinetic chain exercises, open kinetic chain exercises
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Osteoarthritis, Knee
A Safety and Tolerability Study of UBX0101 in Patients With Osteoarthritis of the Knee
A study to evaluate safety, tolerability, and pharmacokinetics of a single intra-articular injection of UBX0101 in patients diagnosed with painful osteoarthritis of the knee.
- Trial name
- NCT03513016
- Testing
- UBX0101
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Unity Biotechnology, Inc.
Knee Osteoarthritis
MRI Study to Evaluate the Safety and Efficacy of SM04690 for Knee Osteoarthritis
The purpose of this study was to evaluate the safety and efficacy of lorecivivint (LOR) injected in the target knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects.
- Trial name
- NCT03706521
- Testing
- lorecivivint
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Biosplice Therapeutics, Inc.
Chronic Pain, Osteoarthritis
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release (PR) in participants suffering from severe chronic pain due to osteoarthritis of the knee…
- Trial name
- NCT00982280
- Testing
- Tapentadol PR
- Where
- 24 sites in Australia, Denmark and 4 more
- Volunteers
- 82 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis Of Knee
Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
Primary aim: evaluate efficacy of subcutaneous injection of etanercept for moderate and severe knee osteoarthritis. Second aim: investigate the potentiality of serum cytokines (TNF-α, Interleukin 1-α (IL1-α), IL1-β, matrix…
- Trial name
- ESIETNKOA (NCT02722811)
- Testing
- Etanercept, Health education, exercise and diet guidance
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University