Clinical trials: Severe Maternal Morbidity
Severe Maternal Morbidity, Maternal Death
The Effects of Medicaid Policy Interventions on Severe Maternal Morbidity
The goal of this study is to learn about the effects of Medicaid policy interventions on severe maternal morbidity (SMM) and mortality and maternal health. The main questions it aims to answer are: 1.
- Trial name
- NCT05678699
- Testing
- Medicaid healthcare quality interventions (incentive payment and obstetric bundled payment), Doula, Standard Care
- Where
- United States
- Volunteers
- 10,000,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Maternal Health, Infant Health
Using Advanced Data Systems to Improve Health in Early Life in Rural Nepal
The goal of this cluster randomized controlled trial is to study the effect of a mobile-phone based application used by pregnant women on maternal and newborn health indicators.
- Conditions
- Maternal Health, Infant Health, Institutional Delivery, Birth Preparedness and Complication Readiness
- Trial name
- CITH (NCT05697822)
- Testing
- Mobile Phone and Cloud-based Electronic Contact and Recording System
- Where
- Nepal
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Amit Arjyal
Maternal Death, Maternal Morbidity
BetterBirth: A Trial of the WHO Safe Childbirth Checklist Program
The purpose of this study is to measure the impact of a checklist-based childbirth safety program (the WHO Safe Childbirth Checklist Program) on reduction of severe maternal, fetal, and newborn harm in institutional deliveries in…
- Conditions
- Maternal Death, Maternal Morbidity, Stillbirth, Neonatal Death
- Trial name
- BetterBirth (NCT02148952)
- Testing
- WHO Safe Childbirth Checklist Program
- Where
- India
- Volunteers
- 157,689 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Postpartum Hemorrhage, Postpartum Preeclampsia
Postpartum Video Education
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal…
- Conditions
- Postpartum Hemorrhage, Postpartum Preeclampsia, Postpartum Sepsis, Postpartum Depression
- Trial name
- NCT05159726
- Testing
- Video Education
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University
Postpartum Depression (PPD), Cardiac Event
Living Healthy for Moms RCT
LHMoms is a novel integrated care intervention that focuses intensively on care continuity and community-to-healthcare linkages for postpartum birthing individuals.
- Trial name
- LHMoms (NCT06666400)
- Testing
- LHMoms Intervention, No intervention
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- Columbia University
Genital Herpes Simplex, Maternal Morbidity
Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity
Severe Maternal Morbidity (SMM) has been associated with maternal mortality, fetal risk, and long-term maternal risk. African American (AA) women are at consistently higher risk than White women.
- Conditions
- Genital Herpes Simplex, Maternal Morbidity, Racial Disparities
- Trial name
- PCORISMM (NCT05429346)
- Where
- United States
- Volunteers
- 339,000 people
- Sponsor
- Kaiser Permanente
Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced
Community Support and Mobile Apps to Help Black Women Control High Blood Pressure After Pregnancy
The goal of this randomized clinical trial is to evaluate the effectiveness of a collaborative care intervention, consisting of remote blood pressure monitoring and support from community health workers, in improving blood…
- Conditions
- Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced, Severe Maternal Morbidity, Postpartum Hypertension
- Trial name
- PRIME CARE (NCT07606027)
- Testing
- Collaborative care, Standard of Care (SOC)
- Volunteers
- 404 people
- Sponsor
- University of Nebraska
Maternal Death, Maternal Morbidity
Improving Women's Health Through Coordinated Postpartum Planning
The purpose of the study is to design, implement, and evaluate a holistic postpartum women's health care system for women who have cardiovascular risk factors for severe maternal morbidity (SMM) including chronic hypertension…
- Trial name
- NCT05430815
- Testing
- Enhanced Postpartum Care System
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Emory University
HELLP Syndrome (HELLP), Third Trimester, Complement Abnormality
The Use of Eculizumab in HELLP Syndrome
This research study is being performed to see if women diagnosed with early preterm Hemolysis, Elevated Liver Enzymes, Low Platelets (HELLP) syndrome (estimated gestational ages of 23-30 weeks) benefit from a medication called…
- Conditions
- HELLP Syndrome (HELLP), Third Trimester, Complement Abnormality, Morbidity;Newborn, Maternal Injury
- Trial name
- NCT04103489
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Maternal and Newborn Health
Risk Factors for Severe Morbidity and Mortality in Mothers and Neonates
Improving maternal and infant mortality are key priorities in Kenya and internationally. This study aims to establish a hospital-based surveillance system for pregnant women so that the contribution of risk factors (HIV and other…
- Trial name
- KIPMAT (NCT01757028)
- Where
- Kenya
- Volunteers
- 4,600 people
- Sponsor
- University of Oxford
Severe Preeclampsia
Factors Associated With Blood Pressure Control Failure to Intravenous Labetalol in Severe Preeclampsia
Severe preeclampsia is a serious pregnancy complication that can lead to severe maternal and fetal outcomes, particularly when blood pressure is not adequately controlled.
- Trial name
- RELAPSE (NCT07547046)
- Where
- 14 sites in France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia, Hypertensive Disorder of Pregnancy
Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
This is a single site, single-blinded parallel randomized control trial that investigates a multi-level intervention to improve postpartum blood pressure in women with hypertensive disorder pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Toxemia, Pregnancy Complications
- Trial name
- HHD (NCT05655936)
- Testing
- Heart Health Doula Intervention Program, Usual Care
- Where
- United States
- Volunteers
- 454 people
- Sponsor
- University of Pittsburgh
Perinatal Decision Making
Improving Safety, Patient Experience and Equity Through Shared Decision-making Huddles in Labor
To evaluate the effectiveness of an existing quality improvement (QI) training program known as TeamBirth, using a randomized stepped-wedge hybrid type II study design, to (a) decrease nulliparous term singleton vertex (NTSV)…
- Trial name
- I'M SPEAKING (NCT06828406)
- Testing
- TeamBirth
- Where
- 22 sites in United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Morbidity;Perinatal
Enriched Holistic Care to Eradicate Disparities in Maternal Morbidity
The goal of this randomized controlled intervention trial is to evaluate an integrated, interdisciplinary, multi-level maternity care home model (MCHM) aimed at reducing severe maternal morbidity (SMM) among a group of Black…
- Trial name
- ENHANCED (NCT06245057)
- Testing
- Maternity care home model (MCHM)
- Where
- 2 sites in United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
PTSD (Childbirth-Related), Severe Maternal Morbidity
Debriefing Consult for Psychiatric Symptoms After Severe Maternal Morbidity
The primary objective of this study is to determine if a maternal fetal medicine (MFM) debriefing consult six to eight weeks postpartum reduces self-reported post-traumatic stress, depression, and anxiety symptoms following a…
- Conditions
- PTSD (Childbirth-Related), Severe Maternal Morbidity, Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT07684521
- Testing
- Virtual maternal fetal medicine debriefing consult
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Cedars-Sinai Medical Center
Maternal Death
Reducing Racial Disparities in Severe Maternal Morbidity
There is a paucity of research examining the intersection of race, ethnicity, maternal safety bundles, doulas, and maternal outcomes in Black women at increased risk of severe maternal morbidity and mortality.
- Trial name
- NCT04879797
- Testing
- Implementation of Maternal Safety Bundles, Doula Services
- Where
- United States
- Volunteers
- 1,538 people, healthy volunteers welcome
- Sponsor
- Tufts University
Cesarean Section Complications, Postpartum Hemorrhage
Obstetric Comorbidity Index in Postpartum Hemorrhage
The objective of this study is to examine the predictive capability of the Obstetric comorbidity index in the identification of severe maternal morbidity associated with postpartum hemorrhage in patients undergoing cesarean…
- Conditions
- Cesarean Section Complications, Postpartum Hemorrhage, Morbidity;Perinatal
- Trial name
- NCT06431204
- Testing
- Obstetric comorbidity index
- Where
- Thailand
- Volunteers
- 583 people
- Sponsor
- Mahidol University
Postpartum Hemorrhage, Maternal Morbidity
Secondary Postpartum Hemorrhage
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal mortality and morbidity worldwide, including in France, where it accounts for approximately 20% of maternal mortality.
- Conditions
- Postpartum Hemorrhage, Maternal Morbidity, Retained Placenta, Postpartum Endometritis
- Trial name
- SPPH (NCT03840889)
- Testing
- Data collection
- Where
- 10 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Severe Maternal Morbidity
MOMs Chat and Care Study
The purpose of this study is to test the effectiveness of an integrated care model approach at two different levels of intensity designed to facilitate timely, appropriate care to reduce risk for SMM.
- Trial name
- MOMs-CC (NCT06335381)
- Testing
- Maternal Health Education Resources, Prenatal Telehealth Visits, Postpartum Telehealth Visits
- Where
- United States
- Volunteers
- 674 people
- Sponsor
- Northwell Health
Morbidity;Perinatal, Pregnancy Complications
Postpartum Outcomes in BC
For every case of maternal death, many more women experience life-threatening complications during pregnancy and childbirth. Yet, severe maternal morbidity (SMM) cases are often overlooked post-delivery.
- Conditions
- Morbidity;Perinatal, Pregnancy Complications, Pregnancy Related
- Trial name
- NCT05461183
- Testing
- Retrospective database analysis
- Volunteers
- 15,000 people
- Sponsor
- University of British Columbia