Clinical trials: Severe Mitral Valve Regurgitation
Cardiovascular Diseases
Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation
The objective of this trial is to compare the safety, the efficacy and the cost-effectiveness of 2 therapeutic strategies (optimal standard of care therapy alone versus percutaneous MitraClip procedure and optimal standard of…
- Trial name
- MITRA-FR (NCT01920698)
- Testing
- Percutaneous MitraClip Device Implantation, control
- Where
- 40 sites in France
- Volunteers
- 304 people
- Sponsor
- Hospices Civils de Lyon
Mitral Valve Insufficiency, Mitral Regurgitation
Transcatheter Mitral Valvuloplasty Pilot Study
This study is to evaluate the efficacy and safety of Transcatheter Mitral Valvuloplasty for Severe Mitral Regurgitation
- Conditions
- Mitral Valve Insufficiency, Mitral Regurgitation, Mitral Valve Regurgitation
- Trial name
- MitraClip (NCT04351984)
- Testing
- MitraClip
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Duk-Woo Park, MD
Mitral Regurgitation
Safety and Performance Study of the MitralStitch Repair System.
The main objective is to assess the effectiveness and safety of the MitralStitch repair system in patients with moderate to severe and severe mitral regurgitation.
- Trial name
- NCT04080362
- Testing
- MitralStitch
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hangzhou Valgen Medtech Co., Ltd
Mitral Regurgitation
Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery
The objective of the study is to demonstrate the non-inferiority for clinical efficacy of an endovascular treatment strategy with the MitraClip® in comparison with a surgical treatment strategy in patients with severe primary…
- Trial name
- MITRA-HR (NCT03271762)
- Testing
- percutaneous mitral valve repair with MITRACLIP NT, MITRACLIP NTR/XTR, MITRACLIP G4NT/XT, MITRACLIP G4NTW/XTW, cardiac surgery
- Where
- 31 sites in France
- Volunteers
- 330 people
- Sponsor
- Nantes University Hospital
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Major Depressive Disorder, Recurrent, Mild, Depressive Disorder, Major
Cortical Excitability and Inhibition in MDD
The purpose of this study is to learn if measures of brain activity are different in children and adolescents with depression who are in different stages of treatment.
- Trial name
- NCT01718730
- Testing
- Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Spectroscopy and Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
Aortic Valve Stenosis, Mitral Regurgitation
Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions
Prospective, single-arm, observational study with invasive coronary physiology measurements before and after transcatheter left-sided valvular intervention.
- Conditions
- Aortic Valve Stenosis, Mitral Regurgitation, Coronary Artery Disease, Fractional Flow Reserve
- Trial name
- POTUS (NCT05374733)
- Testing
- Coronary Physiology assessment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Major Depressive Disorder, Major Depressive Episode
MRS and Medication Response: A Pilot Study
We hope to demonstrate that magnetic resonance spectroscopy can detect brain concentration levels of paroxetine (Paxil) or citalopram (Celexa) or escitalopram (Lexapro) in depressed patients.
- Conditions
- Major Depressive Disorder, Major Depressive Episode, Major Depressive Disorder, Recurrent, Major Depression Mild
- Trial name
- NCT03254342
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mitral Regurgitation
Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial
Evaluate the safety and efficacy of Medtronic Intrepid™ TMVR TF System in patients with moderate-to-severe or severe symptomatic mitral regurgitation, or moderate symptomatic mitral regurgitation combined with mitral stenosis in…
- Trial name
- APOLLO-EU (NCT05496998)
- Testing
- Medtronic Intrepid™ TMVR TF System
- Where
- 38 sites in Denmark, France and 6 more
- Volunteers
- 400 people
- Sponsor
- Medtronic Cardiovascular
Glioblastoma Multiforme, Anaplastic Astrocytoma
Examination of Changes on Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) in Patients Who Receive Gliadel Wafers During Initial Surgery for Glioblastoma Multiforme. Response or Failure to Gliadel Wafers for Subjects With Glioblastoma Multiforme.
Subjects with newly diagnosed brain tumors who undergo surgical resection and whose pathology in the operating room shows a high grade glioma will be eligible.
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma
- Trial name
- Gliadel-MRS (NCT00645385)
- Testing
- MRS Spectroscopy
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Degenerative Mitral Regurgitation (MR) Due to Leaflet Prolapse
Early Mitral ValvE Repair Versus Watchful Waiting for Asymptomatic SEvere Degenerative Mitral Regurgitation
Degenerative mitral regurgitation (MR) due to leaflet prolapse is frequent and can be surgically repaired in the vast majority of patients.
- Trial name
- REVERSE-MR (NCT03389542)
- Testing
- Surgery, Clinical interview and echocardiography
- Where
- 2 sites in France
- Volunteers
- 424 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Mitral Valve Regurgitation (Degenerative or Functional)
Edwards EVOQUE Eos MISCEND Study
Study to evaluate the safety and performance of the Edwards EVOQUE Eos mitral valve replacement system
- Trial name
- NCT02718001
- Testing
- Edwards EVOQUE Eos Mitral Valve Replacement System
- Where
- 19 sites in United States, Canada
- Volunteers
- 123 people
- Sponsor
- Edwards Lifesciences
Mitral Valve Regurgitation
First-In-Human Clinical Study for Treatment of Severe Mitral Valve INsufficiency With Epygon™ TRanscatheter Mitral VAlve System
The EPYGON VALVE is an innovative mitral valve, intended for valve replacement of a native mitral valve through a minimally invasive implant procedure by means of a dedicated implant device.
- Trial name
- NCT04775108
- Testing
- Epygon™ Transcatheter Mitral Valve System
- Where
- 10 sites in Austria, Italy and 2 more
- Volunteers
- 40 people
- Sponsor
- Epygon
Mitral Regurgitation, Degenerative Mitral Valve Disease
Safety and Efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate-severe or Severe Degenerative Mitral Regurgitation
To observe and evaluate the safety and efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate-severe or Severe Degenerative Mitral Regurgitation through a prospective, multicenter…
- Trial name
- NCT05655897
- Testing
- GeminiOne Transcatheter Valve Edge-to-Edge Repair System
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peijia Medical Technology (Suzhou) Co., Ltd.
Moderate or Severe Mitral Regurgitation
Novel 3-dimensional Echocardiographic Quantification of Mitral Regurgitant Volume
The goal of this observational study is demonstrate that a novel artificial intelligence based software for the quantification of the mitral regurgitation on 3-dimensional transesophageal echocardiography (3D CFQ) is more…
- Trial name
- AIM_3D (NCT07528781)
- Testing
- analysis of the performance of an artificial intelligenced based software for analysis of 3D tranesophageal echocardiography data
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Germans Trias i Pujol Hospital
Mitral Valve Insufficiency
Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System
PILOT: The study is a pilot trial to evaluate the safety and performance of the Twelve TMVR System in high risk mitral regurgitation patients.
- Trial name
- NCT02322840
- Testing
- Twelve TMVR Implant, Medtronic Intrepid™ Transcatheter Transfemoral Mitral Valve Replacement System
- Where
- 32 sites in United States, Australia and 5 more
- Volunteers
- 128 people
- Sponsor
- Medtronic Cardiovascular
Severe Degenerative Mitral Regurgitation
Predictors of Postoperative Left Ventricular Function in Patients Undergoing Mitral Valve Repair for Severe Degenerative Mitral Regurgitation
The aim of the study is to investigate whether a predictive score (combination of several validated predictors) better predicts postoperative left ventricular function than any single predictor in patients undergoing mitral valve…
- Trial name
- NCT01519050
- Testing
- mitral valve repair
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Ketogenic Diet and Neuromodulation in Treatment Resistant Depression
The goal of this clinical trial is to learn if combining a ketogenic diet with a personalized, accelerated brain stimulation treatment (iTBS) works better than iTBS with a standard healthy diet to reduce depression symptoms in…
- Trial name
- ALIGN (NCT07376018)
- Testing
- Accelerated Intermittent Theta Burst Stimulation (iTBS), Ketogenic Diet, Canadian Food Guide-Aligned Diet
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Aortic Regurgitation, Functional Mitral Regurgitation
Fate of Moderate Secondary Mitral Regurgitation in Patients Undergoing Aortic Valve Surgery for Severe Aortic Regurgitation
Patients with severe aortic regurgitation (AR) may be affected, in many cases, by a concomitant moderate or severe mitral regurgitation (MR).
- Trial name
- NCT05774808
- Testing
- Aortic valve replacement, Mitral valve annuloplasty
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Michele De Bonis
Degenerative Mitral Valve Disease
Clinical Study of NovoClasp for Treating Moderate to Severe and Severe Degenerative Mitral Regurgitation
To validate the safety and efficacy of transcatheter edge-to-edge repair (TEER) using the NovoClasp® transcatheter mitral valve clip and steerable guide catheter in the treatment of moderate to severe and severe degenerative…
- Trial name
- NCT06021509
- Testing
- NovoClasp® transcatheter mitral valve clip and steerable guide catheter
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Enlight Medical Technologies (Shanghai) Co., Ltd