Clinical trials: Severe Obesity
Morbid Obesity, Bariatric Surgery Candidate
Preoperative Condition in Giant Obese Patients
The frequency of super-super obese who need immediate weight loss surgery is risen continuously. For those patients a prior-to-surgery conditioning therapy is mandatory to gain technical and physical operability.
- Trial name
- NCT02616003
- Testing
- Liraglutide, Aminosteril hepa 8%, Caloric diet with 1000 kcal
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Sana Klinikum Offenbach
Anesthesia, Regional Anesthesia
Laparoscopic Sleeve Gastrectomy Surgery and External Oblique Intercostal Block
In obese patients, adequate pain relief in the postoperative period is an important parameter that affects patient comfort and hospital stay.
- Conditions
- Anesthesia, Regional Anesthesia, Morbid Obesity, Postoperative Pain
- Trial name
- NCT05822479
- Testing
- Bilateral ultrasound guided external oblique intercostal block (EOIB), Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Glycine Metabolism Disturbances, Insulin Resistance
Obesity-Related Glycine Deficiency: Investigating a Long-standing Metabolic Paradox Using Bedside and Bench Approaches
Obesity, in addition to causing abnormal glucose and lipid metabolism, is also associated with altered plasma concentrations of multiple amino acids, including increased levels of branched-chain amino acids and decreased levels…
- Conditions
- Glycine Metabolism Disturbances, Insulin Resistance, Morbid Obesity, Oxidative Stress
- Trial name
- NCT04660513
- Testing
- Bariatric surgery
- Where
- Singapore
- Volunteers
- 42 people
- Sponsor
- Singapore General Hospital
Clinically Severe Obesity, Metabolic Complications After Jejunoileal Bypass
Laparoscopic Revision of Jejunoileal Bypass to Gastric Bypass
This study objectives are the following. To describe the updated clinical presentation, indications, and multidisciplinary medical management of patients with a failed and/or complicated jejunoileal bypass (JIB).
- Conditions
- Clinically Severe Obesity, Metabolic Complications After Jejunoileal Bypass, Nutritional Complications After Jejunoileal Bypass, Obesity Recidivism
- Trial name
- JIB-to-RYGB (NCT01040533)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Francisco
Morbid Obesity
Early Feasibility for Safety & Device Functionality of SFM Anastomosis Device Used in 3 Procedures (SNAP-S) or (SNAP-PS) or (J-J)
The objectives of this study are to assess the initial safety and device functionality of the SFM Anastomosis System including delivery systems when used to create a duodenal-ileal (D-I) anastomosis either during sleeve…
- Trial name
- GIW-SFM (NCT06199635)
- Testing
- Self-Forming Magnetic Anastomosis Device and Delivery System
- Where
- 2 sites in Chile, India
- Volunteers
- 28 people
- Sponsor
- GI Windows, Inc.
Morbid Obesity
Efficacy and Mechanism Study of Bariatric Surgery to Treat Moderate to Severe Obesity in Han Chinese Population
This is a long-term follow-up and interventional study in individuals who have been diagnosed with moderate to severe obesity with or without diabetes.
- Trial name
- NCT02653430
- Testing
- Sleeve gastrectomy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Morbid Obesity, Severe Obesity
Trial Assessing the Immunogenicity and Safety of Two Influenza Vaccine Strategies Among Severe Obese Adult Patients
Obesity has been considered as a risk factor for mortality and development of complications during infection with the influenza virus.
- Trial name
- FLUO (NCT05409612)
- Testing
- Supemtek®, Vaxigriptetra®
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Extreme Obesity
Course of Obesity and Extreme Obesity in Adolescents
The rate of adolescent extreme obesity is rapidly rising, and impacting quality of life, psychosocial situation, and health of the affected youth.
- Trial name
- YES (NCT01662271)
- Where
- 5 sites in Germany
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Martin Wabitsch
Morbid Obesity
Effect of Boussignac CPAP Ventilation on PaO2 and PaO2/FiO2 Ratio in Morbidly Obese Patients Undergoing Bariatric Surgery
The purpose of this study is to determine if the application of Boussignac continuous positive airway pressure (CPAP) immediately after extubation improves PaO2 and PaO2/FiO2 ratio in morbidly obese patients undergoing gastric…
- Trial name
- NCT02297828
- Testing
- Boussignac CPAP, Venturi face mask
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Centro Hospitalar do Porto
Obesity
Effectiveness of Two Different Body Positions During Facemask Ventilation in Obese Patients
It is important to provide enough oxygen to the patients who are asleep during surgery. One way to do this is by using a mask placed over the face to help them breathe.
- Trial name
- NCT06305273
- Testing
- Head position for face mask ventilation during induction supine, Head position for face mask ventilation during induction head elevated
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Morbid Obesity, Metabolic Syndrome
Impact GLP-1 Agonists Following Bariatric
Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic…
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes Mellitus, Hypertension
- Trial name
- NCT06132477
- Testing
- GLP-1 receptor agonist
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Missouri-Columbia
Morbid Obesity Requiring Bariatric Surgery
Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?
The goal of this observational study is to evaluate whether preoperative fat-free mass predicts post-operative weight loss in patients undergoing Roux-En-Y gastric bypass.
- Trial name
- FLAG (NCT07565051)
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University Hospital, Geneva
Morbid Obesity
Outcomes of Gastric Band Fills as Found With a Patient Self-reported Questionnaire: The Vomiting, Eating, and Weight Loss (VEW) Questionnaire
1. Background / Scientific Rationale The VEW (Vomiting, Eating, and Weight Loss) Questionnaire has been developed as a method for the assessment of post bariatric surgery patients, as well as a research tool into the eating…
- Trial name
- NCT01105156
- Testing
- VEW Questionnaire
- Where
- Australia
- Volunteers
- 361 people
- Sponsor
- North Eastern Weight Loss Surgery
Thyroid Function, Obesity
The Effect of Bariatric Surgery on Thyroid Function and Morphology
The aim is to evaluate the effect of dramatic weight loss after bariatric surgery on thyroid function (thyroid hormone levels and particulary morphological changes) in the short and long-term setting of a cross-sectional study.
- Trial name
- NCT00871130
- Testing
- Bariatric surgery
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Morbid Obesity
Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy
The sleeve gastrectomy that has been utilized as a first-stage bariatric procedure to reduce surgical risk in high-risk patients by induction of weight loss is now gaining popularity as a standalone procedure for the treatment of…
- Trial name
- NCT00667706
- Testing
- laparoscopic operation Sleeve Gastrectomy, laparoscopic operation Roux-en-Y Gastric bypass
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Morbid Obesity
Polyphenol Supplementation and Morbid Obesity Parameters
This parallel, double-blind, randomised controlled trial aims to assess the effect of a polyphenol-rich dietary supplement on obesity parameters, in combination with a hypocaloric diet, for adults with morbid obesity, bariatric…
- Trial name
- NCT05428540
- Testing
- Polyphenol-rich supplement
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Childhood Obesity
Magnetic Resonance Imaging Assessment of Multiorgan Health in Obesity
The goal of this study is to quantify the body composition and organ fat distribution changes with obesity interventions in adolescents with severe obesity.
- Trial name
- FIT-YOUNG (NCT07702825)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Morbid Obesity
Effectiveness and Safety Study of LAP-BAND Treatment for Obese Adolescents
The purpose of this study is to determine whether the LAP-BAND system is safe and effective in morbidly obese adolescents.
- Trial name
- NCT00447590
- Testing
- LAP-BAND System
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Apollo Endosurgery, Inc.
Obesity, Morbid Obesity
Effects of a Novel Dietary Intervention on Body Composition After Laparoscopic Gastric Bypass Surgery
We propose to compare the standard of care with the use of a novel medical food in 6 bariatric surgery patients by measuring outcomes of body composition, quality of life, hair loss, muscle strength, resting energy expenditure…
- Trial name
- NCT01041261
- Testing
- BariatrX Essentials 360 Treatment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- MetaProteomics LLC
Morbid Obesity, Hiatal Hernia
Laparoscopic Sleeve Gastrectomy With or Without Hiatal Hernia Repair in Morbidly Obese Patients
Background: Obesity and hiatal hernia are both risk factors of gastroesophageal reflux disease (GERD), and the incidence of hiatal hernia is much higher in morbidly obese patients.
- Conditions
- Morbid Obesity, Hiatal Hernia, Gastroesophageal Reflux Disease, Sleeve Gastrectomy
- Trial name
- NCT03776669
- Testing
- Laparoscopic sleeve gastrectomy + Hiatal hernia repair, Laparoscopic sleeve gastrectomy alone
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital