Clinical trials: Severe Obesity
Bariatric Surgery, Morbid Obesity
Pharmacokinetics of Rivaroxaban After Bariatric Surgery
Data on pharmacokinetics of rivaroxaban after bariatric surgery and in morbid obesity are sparse. The aim of this study is to assess the pharmacokinetic and pharmacodynamic parameters of rivaroxaban, used at a therapeutic…
- Trial name
- ABSORB (NCT04180436)
- Testing
- rivaroxaban 20 mg once daily 8 days
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Morbid Obesity
Fentanyl Metabolism in Obese Adolescents
Fentanyl is a frequently used pain medication in pediatric and adult anesthesia. Although there are some studies considering the breakdown of oral, transmucosal and intravenous fentanyl preparations in children, the disposition…
- Trial name
- NCT01955993
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Morbid Obesity
An Evaluation of the Outcomes of Bariatric Surgery - a Cohort Study
A prospective bariatric database was carried out in the Department of Digestive and Endocrine Surgery at the University Hospital of Strasbourg, France, starting in January 1996.
- Trial name
- ChirBar (NCT02811900)
- Testing
- Roux en Y gastric bypass, Sleeve gastrectomy, Gastric banding
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- IHU Strasbourg
Diabetes Mellitus, Prediabetes
Long Term Diabetes Improvement After Cancer Gastrectomy and Colectomy
There is evidence that gastrointestinal operations for non weight-losing purposes are beneficial for diabetes mellitus. Aiming to analyze such hypothesis, patients submitted to gastric bypass for morbid obesity, gastrectomy for…
- Conditions
- Diabetes Mellitus, Prediabetes, Morbid Obesity, Gastric Cancer
- Trial name
- NCT01518023
- Testing
- Interview, questionnaire, updated biochemical tests
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- University of Sao Paulo
Obesity, Spine Condition
Longitudinal Changes in Spinopelvic Alignment and Sagittal Balance After Bariatric Surgery in Patients With Morbid Obesity: A Prospective Observational Study
The goal of this prospective observational study is to understand how major weight loss after bariatric surgery may be associated with changes in the way the spine and pelvis are aligned in adults with morbid obesity.
- Trial name
- BARISPINOALIGN (NCT07794553)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Obesity & Overweight
Weight Trajectories and Predictive Factors After Semaglutide in Patients With Grade 3 and Complicated Obesity
SEMAFOLLOW is a real-world follow-up study examining the outcomes of individuals treated with WEGOVY® (semaglutide 2.4 mg) under the temporary authorisation for use (ATU) and early access programme in France.
- Trial name
- SEMAFOLLOW (NCT07423481)
- Testing
- SEMAFOLLOW questionnaire
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Nantes University Hospital
Severe Obesity
Impact of Telemonitoring on Metabolic Variables in Severe Obesity
The goal of this clinical trial is to compare, in a population of severely obese patients, two different kinds of follow-up after discharge from in-hospital rehabilitation programme.
- Trial name
- teleob (NCT05786092)
- Testing
- Telemonitoring
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Auxologico Italiano
Generalized Lipodystrophy
A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)
This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months.
- Trial name
- NCT06548100
- Testing
- mibavademab
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Regeneron Pharmaceuticals
Clinically Severe Obesity
Very Long Term Results After Laparoscopic Retrocolic Antegastric Gastric Bypass
The main aim of this study is to analyze and report the very long-term outcomes after primary laparoscopic proximal Roux-en-Y gastric bypass surgery for clinically severe obesity.
- Trial name
- >10yrsRYGB (NCT01040507)
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- University of California, San Francisco
Obesity, COVID-19 Infection
Efficiency and Security of NIVOLUMAB Therapy in Obese Individuals With COVID-19(COrona VIrus Disease) Infection
Although SARS-CoV-2 (Severe Acute Respiratory Syndrome-associated coronavirus) due to COVID-19 evolves poorly towards ARDS (Acute Respiratory Distress Syndrome) and death, there is to date no validated drug available for severe…
- Trial name
- NIVISCO (NCT04413838)
- Testing
- NIVOLUMAB, Routine standard of care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Morbid Obesity
Ketodex Versus Opioid Based Anesthesia in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy.
comparing Opioid sparing anesthesia using ketodex versus opioid based anesthesia in obese patients undergoing laparoscopic sleeve gastrectomy.
- Trial name
- Ketodex (NCT07246447)
- Testing
- ketamine and dexmeditomidine combination, Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cairo University
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Obesity
Transoral Gastric Volume Reduction as an Intervention for Weight Management
The purpose of this study is to evaluate the safety, technical feasibility, and initial effectiveness (i.e., weight loss primarily measured as percent excess weight loss) of TGVR performed using the Bard RESTORe Suturing System
- Trial name
- TRIM (NCT00679848)
- Testing
- RS2 (RESTORe Suturing System)
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- C. R. Bard
Gastroesophageal Reflux Disease, Morbid Obesity
Effect of Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass on Gastroesophageal Reflux Disease: An 8-Year Prospective Cohort Study
This study represents a long-term observational follow-up of patients who had previously undergone bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass) in the context of an earlier interventional trial…
- Trial name
- NCT03692455
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Clinica Gastrobese
Obesity, Morbid Obesity
The Effect of Cognitive Function Level in Morbidly Obese Patients
Obesity is a disease caused by many factors, such as lifestyle, eating habits, lack of physical activity, hormonal and genetic influences. These different factors make treatment planning difficult.
- Trial name
- NCT07032415
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Kocaeli City Hospital
Negative-pressure Wound Therapy, Morbid Obesity
Prophylactic Post-Cesarean Incisional Negative-pressure Wound Therapy in Morbidly Obese Patients
To evaluate the effectiveness of negative-pressure wound therapy in decreasing wound complications in morbidly obese patients (BMI greater than of equal to 40) at Albany Medical Center Hospital.
- Conditions
- Negative-pressure Wound Therapy, Morbid Obesity, Cesarean Section, Wound Infection
- Trial name
- NCT02901613
- Testing
- Negative-pressure wound therapy
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Morbid Obesity
Morbid Obesity: Effects of Conservative Treatments and Gastric Bypass Surgery
The purpose of this study is to evaluate the effects of conservative treatments of obesity with surgery (gastric bypass).
- Trial name
- NCT00239850
- Testing
- lifestyle changes
- Where
- Norway
- Volunteers
- 209 people
- Sponsor
- Norwegian University of Science and Technology
Obese, Antibiotic Prophylaxis
Serum Concentration of CEFOxitin Used for Antibiotic Prophylaxis in Obese Patients Undergoing BARiatric Surgery
Obesity is a pandemic problem in modern societies. Bariatric surgery (gastric by-pass and sleeve gastrectomy) has emerged as an efficient treatment to reduce morbidity and mortality related to obesity.
- Conditions
- Obese, Antibiotic Prophylaxis, Bariatric Surgery Candidate
- Trial name
- CEFOBAR (NCT03306290)
- Testing
- Serum dosage of antibiotic prophylaxis CEFOXITIN
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Morbid Obesity
Gastric Recalibration After Endoscopic Sleeve Gastroplasty
Endoscopic sleeve gastroplasty (ESG) is a technique used for bariatric surgery, with results comparable to conventional surgery, in order to treat morbid obesity.
- Trial name
- ESG-IRM (NCT04945473)
- Testing
- Endoscopic placement of additional sutures
- Where
- France
- Volunteers
- 100 people
- Sponsor
- IHU Strasbourg
Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain
Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.
The goal of this randomized clinical trial is to find out whether giving an intravenous lidocaine + dexmedetomidine combination (LIDEX) during laparoscopic bariatric surgery can lower post-operative pain, inflammation, and…
- Conditions
- Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative Analgesia
- Trial name
- NCT07073846
- Testing
- Intravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia
- Where
- 2 sites in Mexico
- Volunteers
- 104 people
- Sponsor
- Instituto Mexicano del Seguro Social