Clinical trials: Severe Obesity
Morbid Obesity
Laparoscopic Sleeve Gasterectomy With or Without Pyloric Botulinum Neurotoxin Injection
Leakage is the most common complication after laparoscopic sleeve gastrectomy which may amount to 20% in some studies. We hypothesize that Clostridium botulinum neurotoxin A (BTX-A) injection into the pyloric sphincter during the…
- Trial name
- NCT02325141
- Testing
- laparoscopic sleeve gastrectomy
- Volunteers
- 130 people
- Sponsor
- Mansoura University
Morbid Obesity
Sleeve Gastrectomy Versus One-anastomosis Gastric Bypass: Randomized Trial
Hormonal changes after SG and OAGB involve alterations in the levels of many enteric hormones, among these hormones are ghrelin and glucagon-like peptide-1 (GLP-1).
- Trial name
- NCT04134156
- Testing
- sleeve gastrectomy, one anastomosis gastric bypass
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Obesity, Weight Loss
Comparison of Weight Loss Programs for Individuals With Severe Obesity
The purpose of this study is to evaluate the effectiveness of a technology-based system (the Body Media FIT system) for enhancing weight loss in severely obese individuals (BMI: ≥ 40 kg/m2).
- Trial name
- NCT01330329
- Testing
- Standard behavioral treatment, SBT + technology system (SBT+FIT)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The Miriam Hospital
Obesity, Abdominal, Surgery
Perioperative Blood Adiponectin Dynamics and Systemic Infflamatory Response After Major Colorectal Surgery
Surgical stress after major abdominal surgery in perioperative period causes neuroendocrine, metabolic and imunologic changes in organism with production of proinfflamatory citokines and results with appearance of systemic…
- Conditions
- Obesity, Abdominal, Surgery, Systemic Inflammatory Response Syndrome, Postoperative Complications
- Trial name
- ADIPOS (NCT06057207)
- Testing
- serum levels of adiponectin, IL-6, Postoperative systemic infflamation
- Where
- 2 sites in Croatia
- Volunteers
- 58 people
- Sponsor
- Osijek University Hospital
Morbid Obesity, Hemodynamic Instability
Effects of Low-Flow Anesthesia on Hemodynamic Parameters and Oxygenation in Morbidly Obese Patients
Low-flow anesthesia has been used for years with positive results, but its effects on hemodynamic parameters and oxygenation are not clearly known in high-risk morbidly obese patients who are prone to pulmonary dysfunction…
- Conditions
- Morbid Obesity, Hemodynamic Instability, Bariatric Surgery Candidate
- Trial name
- Oxygenation (NCT03721536)
- Testing
- hemodynamic parameters, arterial blood gase
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Inonu University
Genetic Forms of Extreme Obesity
The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry
A voluntary prospective study that will allow registration and follow-up of individuals with MC4R pathway genetic obesity.
- Trial name
- NCT03479437
- Where
- 2 sites in United States, Canada
- Volunteers
- 303 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Obesity, Class III, Sleep Apnea, Obstructive
High-Intensity Progressive Inspiratory Muscle Training in Class III Obesity and Obstructive Sleep Apnea
The purpose of this study is to evaluate the feasibility and effects of a 12-week high-intensity progressive Inspiratory Muscle Training (IMT) program in individuals with Class III obesity (BMI ≥ 40 kg/m²) and obstructive sleep…
- Conditions
- Obesity, Class III, Sleep Apnea, Obstructive, Inspiratory Muscle Training
- Trial name
- NCT07469280
- Testing
- High-Intensity Progressive Inspiratory Muscle Training (IMT)
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of the State of Santa Catarina
Morbid Obesity
Comparison of Stapled and Hand-Sewn Sleeve Gastrectomy
Sleeve gastrectomy is a stapler dependent bariatric procedure. A hand-sewn sleeve gastrectomy can be necessary under certain circumstances.
- Trial name
- NCT03982823
- Testing
- Hand-Sewn Sleeve Gastrectomy, Stapled Sleeve Gastrectomy
- Volunteers
- 13 people
- Sponsor
- Inonu University
Surgery, Post-operative Pain
Laparoscopic Single Incision -Vs- Multiple Incision Gastric Band Surgery
A double blinded randomised control trial comparing the differences between laparoscopic single incision versus multiple port bariatric surgery in morbidly obese patients (BMI>35).
- Conditions
- Surgery, Post-operative Pain, Post-operative Recovery
- Trial name
- SIMIS (NCT01844960)
- Testing
- Single Incision Gastric Band Insertion, Multiple Incision Gastric Band Insertion
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- King's College Hospital NHS Trust
Morbid Obesity
Outcomes of Bariatric Surgery/UMMMC Bariatric Surgery Registry
The purpose of this registry is to monitor and evaluate the efficacy, as well as safety, of bariatric surgery performed at UMass Memorial Medical Center, including laparoscopic gastric bypass surgery and laparoscopic gastric…
- Trial name
- NCT01153308
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 4,785 people
- Sponsor
- University of Massachusetts, Worcester
Obesity, Morbid, Time Restricted Eating
Time-restricted Eating Among Pregnant Females With Severe Obesity
In the United States, a body mass index (BMI) of at least 35.0 kg/m2 affects about 15% of women of reproductive age. Severe obesity is a significant predictor of adverse perinatal outcomes including gestational diabetes mellitus…
- Conditions
- Obesity, Morbid, Time Restricted Eating, Pregnancy Weight Gain
- Trial name
- TRE-Preg (NCT06477120)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Obesity, Morbid
Intragastric Injections of Botox for the Treatment of Obesity
One possible angle for treating obesity could be slowing down the gastric emptying time. By prolonging the gastric emptying time, the person would ideally experience increased sensation of satiety, and in the long run reduce food…
- Trial name
- NCT02035397
- Testing
- Botulinum Toxin Type A, Saline solution
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology
Morbid Obesity
Is Preoperative Exercise Test in Morbid Obese Patients a Predictive Test for Extubation?
the purpose of this study is to determine if 60 meter test done prior to surgery is a predictive in terms of extubation in morbid obese patients undergoing morbid obese surgery.
- Trial name
- NCT02220959
- Testing
- walk test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Obesity
Influence of Plantago Major on Mineral Metabolism and Selected Biochemical Parameters in Obese Women
Effect of oral supplementation with Plantago major on cardiometabolic risk factors and mineral content and lifestyle in obese women: double-blind, randomized clinical trial.
- Trial name
- Plantago (NCT03439540)
- Testing
- Plantago major
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Obesity, Cardiac Function
Severe Obesity: Bariatric Surgery vs. Life-Style-Intervention
The purpose of this study is to investigate the effects of weight loss induced by gastric bypass surgery in comparison to a psychotherapy-enhanced lifestyle intervention on cardiopulmonary performance and quality of life in…
- Conditions
- Obesity, Cardiac Function, Quality of Life
- Trial name
- WAS (NCT01352403)
- Testing
- Roux-en-Y gastric bypass, Psychotherapy-enhanced lifestyle intervention
- Where
- Germany
- Volunteers
- 93 people
- Sponsor
- University of Wuerzburg
Laparoscopic Surgery
Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass
This is a retrospective work on 200 morbid obese patients randomized and categorized into 2 groups according to the treatment method: the laparoscopic sleeve gastrectomy (LSG) and LRYGB groups, within the period from 2014 to 2019…
- Trial name
- NCT05145205
- Testing
- Sleeve gastrectomy, Laparoscopic Roux-en-Y gastric bypass
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University
Healthy, Obesity
Effects of Physical Training and Nutrition Education on Adipocytokines in Severely Obese Teenagers
Obesity is now becoming significantly prevalent of an environment characterized by easily available calorics foods combined with sedentary lifestyles.
- Trial name
- OBAPA (NCT01188642)
- Testing
- obesity lifestyle intervention
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Obesity, Weight Loss
Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD
Obesity leads to physiological imbalance resulting in hyperglycemia, dyslipidaemia and inflammation and can generate systematic oxidative stress through multiple biochemical mechanisms.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05055154
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 26 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa
Morbid Obesity, Gastroesophageal Reflux
MGB/OAGB and LSG Effects on Lower Esophageal Sphincter (LES) Function
Background While several articles have reported about the effects of laparoscopic sleeve gastrectomy (LSG) on the lower esophageal sphincter (LES), to date, just one paper has discussed this issue with regard the Mini/One…
- Conditions
- Morbid Obesity, Gastroesophageal Reflux, Bariatric Surgery Candidate
- Trial name
- NCT02987673
- Testing
- MGB/OAGB, LSG
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Mario Musella MD
Morbid Obesity
GlideScope With EGRI Assessment in Obese Patients
BACKGROUND Unpredicted difficult tracheal intubation (DTI) with Macintosh laryngoscopy occurs frequently in obese patients. We investigated the incidence of DTI using the GlideScope® videolaryngoscope (GVL) with an algorithm…
- Trial name
- GLOBE (NCT02188979)
- Where
- Italy
- Volunteers
- 195 people
- Sponsor
- Università degli Studi di Brescia