Clinical trials: Severe Obesity
Obesity, Type 2 Diabetes
Longitudinal Cohort Study Comparing 2 Surgical Techniques in Patients With Class 3 Obesity and Type 2 Diabetes
Wight loss surgery provides good glycemic control in type 2 diabetes. The technique of "Roux-en-Y gastric bypass" is more effective than the "Adjustable Gastric Band" on weight loss.
- Trial name
- OBEDIAB (NCT00688974)
- Testing
- Roux-en-Y gastric bypass, Adjustable gastric band
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Morbid Obesity
CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug
Before and during bariatric surgery patients are given oral and i.v. midazolam, respectively and blood samples are drawn to establish midazolam time-concentration profiles.
- Trial name
- MEMO (NCT01519726)
- Testing
- Midazolam
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- St. Antonius Hospital
Morbid Obesity
Early Feasibility for Safety & Device Functionality of SFM Anastomosis Device Used in 3 Procedures (SNAP-S) or (SNAP-PS) or (J-J)
The objectives of this study are to assess the initial safety and device functionality of the SFM Anastomosis System including delivery systems when used to create a duodenal-ileal (D-I) anastomosis either during sleeve…
- Trial name
- GIW-SFM (NCT06199635)
- Testing
- Self-Forming Magnetic Anastomosis Device and Delivery System
- Where
- 2 sites in Chile, India
- Volunteers
- 28 people
- Sponsor
- GI Windows, Inc.
Morbid Obesity
Subcutaneous NTG for US Radial Artery Cannulation
Clinicians are increasingly dealing with morbid obese patients. In morbid obese patients, difficult sampling and problems encountered with noninvasive blood pressure monitoring makes arterial cannulation an essential skill in…
- Trial name
- NTG-US-art (NCT03006640)
- Testing
- Subcutaneous nitroglycrin, Subcutaneous saline
- Volunteers
- 60 people
- Sponsor
- AlRefaey Kandeel
Severe Obesity
Garcinia Mangostana Extracts in the Management of Weight Loss
Obesity is one of the greatest public health challenges of the 21st century. Its prevalence has tripled in many countries of the European Region since the 1980s, and the numbers of those affected continue to rise at an alarming…
- Trial name
- NCT02823561
- Testing
- Garcinia mangostana, Control group
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Pulmonary Atelectasis, Obesity, Morbid
Effects of Individualized PEEP Guided by Driving Pressure on Postoperative Atelectasis in Patients With Morbid Obesity
Atelectasis is a common complication in patients undergoing surgery under general anesthesia, particularly in obese patients. Postoperative atelectasis could last for more than 24h and contribute to a variety of other…
- Trial name
- NCT06181279
- Testing
- Individualized PEEP group, Fixed PEEP group
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Yongtao Sun
Obesity, Morbid Obesity
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART)
The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the…
- Trial name
- KETOHEART (NCT05781269)
- Testing
- VLCKD, r-MedDiet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Morbid Obesity, Postoperative Complications
Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic One Anastomosis Gastric Bypass
This study try to identify differences in cost, length of operation and results between two different bariatric surgical techniques, the laparoscopic Roux-en-Y gastric bypass and the Single anastomosis laparoscopic gastric…
- Conditions
- Morbid Obesity, Postoperative Complications, Weight Loss
- Trial name
- OAGB-vs-LRYGB (NCT02779322)
- Testing
- Minigastric bypass, Gastric bypass
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Puerta de Hierro University Hospital
Morbid Obesity
Bariatric Embolization of Arteries for the Treatment of Obesity
The purpose of this study is evaluate the safety and effectiveness of bariatric embolization as a minimally-invasive image-guided procedure for morbid obesity.
- Trial name
- BEAT Obesity (NCT02165124)
- Testing
- Artificial Embolization Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Mechanical Ventilation Complication, Respiratory Insufficiency
Transpulmonary Pressures in Mechanical Ventilated Patients With Morbid Obesity
The study consists in determine the transpulmonary pressure in morbidly obesity patients that require mechanical ventilation. both gender only adults Medical intensive care patients.
- Trial name
- NCT02309190
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
Longitudinal Study of the Psychological Impact of Bariatric Surgery
This prospective observational study evaluates the effect of bariatric surgery on mental health and hair cortisol in patients with morbid obesity over a 3-year follow-up.
- Trial name
- BARI-SCL (NCT07780058)
- Where
- 2 sites in Spain
- Volunteers
- 70 people
- Sponsor
- University of Alicante
Morbid Obesity
McGrath Videolaryngoscopy and Direct Laryngoscopy in Morbidly Obese Patients
Our goal is to compare conventional direct laryngoscopy using a Macintosh blade with the McGrath videolaryngoscope for endotracheal intubation in very morbidly obese patients undergoing non-cardiac surgery.
- Trial name
- NCT03467048
- Testing
- McGrath videolaryngoscopy, Direct laryngoscopy
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- The Cleveland Clinic
Pulmonary Atelectasis, Respiratory Tract Diseases
Application Breathing Exercises With Load Inspiratory Postoperative Abdominal Surgery
The aim of this study is to evaluate the effects of the use of breathing exercises with inspiratory loading on respiratory muscle strength and endurance, lung volumes and capacities and thoracoabdominal mobility in patients after…
- Conditions
- Pulmonary Atelectasis, Respiratory Tract Diseases, Pathological Conditions, Signs and Symptoms
- Trial name
- NCT02298517
- Testing
- incentive spirometry, inspiratory load equipment
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Morbid Obesity
An Analysis of Lipid and Glucose Metabolism Following Bariatric Surgery
Bariatric surgery induce remarkable weight loss and improvement or resolution of type 2 diabetes. Obesity is the primary risk factor for type 2 diabetes, and 90% of all type 2 diabetics are obese.
- Trial name
- NCT02067585
- Testing
- Standardized Lipid meals
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Alberta
Obesity, Morbid, Bariatric Surgery Candidate
Investigation of Microbiome-based Prognostical Biomarkers in Patients With Morbid Obesity and Bariatric Surgery
Morbid obesity leads to non-alcoholic fatty liver disease (NAFLD), and not all NAFLD cases benefit from weight loss e.g. after bariatric surgery.
- Conditions
- Obesity, Morbid, Bariatric Surgery Candidate, NAFLD, Microbiome
- Trial name
- NCT03391401
- Testing
- Bariatric surgery
- Where
- 2 sites in Germany
- Volunteers
- 204 people
- Sponsor
- St. Franziskus Hospital
Weight Loss, Bariatric Surgery Candidate
Liraglutide Effectiveness in Preoperative Weight-loss for Bariatric-metabolic Surgery
Severe obesity is associated with considerable reduction of wellbeing and life expectancy. People living with severe obesity tend to die 8 to 10 years earlier.
- Conditions
- Weight Loss, Bariatric Surgery Candidate, Obesity, Morbid
- Trial name
- NCT06201819
- Testing
- Liraglutide injection
- Where
- Mexico
- Volunteers
- 37 people
- Sponsor
- Hospital Civil Juan I. Menchaca
Bariatric Surgery Candidate, Obesity
The Effect of Exercise in Patients Awaiting Bariatric Surgery
The aim of this project is to understand the impact of a four week preoperative exercise programme on fitness and metabolic rate and weight before surgery.
- Trial name
- BariPrehab (NCT05235945)
- Testing
- Online exercise intervention
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London
Anesthesia, Intubation;Difficult
Awake Nasal Fiber-optic Intubation of Severely Obese Patients in Lateral Position
Airway management in severely obese patients remains a challenging issue for anesthetists and may lead to life-threatening situations.
- Conditions
- Anesthesia, Intubation;Difficult, Intubation; Difficult or Failed, Anesthesia Intubation Complication
- Trial name
- NCT04779528
- Testing
- Fiberoptic intubation in supine position., Fiberoptic intubation in lateral position.
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Dexmedetomidine, Fentanyl
Dexmedetomidine vs Fentanyl on Time to Extubation in Patients Undergoing Laparoscopic Sleeve Gastrectomy
This study aims to compare the efficacy of dexmedetomidine versus fentanyl during general anesthesia for patients with morbid obesity undergoing laparoscopic sleeve gastrectomy.
- Conditions
- Dexmedetomidine, Fentanyl, Time to Extubation, Morbid Obesity
- Trial name
- NCT06052111
- Testing
- Group F (fentanyl group), Group D (dexmedetomidine group)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Helwan University
Morbid Obesity, Weight Loss
Effects of Long Biliopancreatic Limb vs. Long Alimentary Limb in Superobesity, a Randomized Study
Super Obesity, i.e. a BMI above 50, is difficult to treat. Normal gastric bypass surgery is not always enough for proper weight control. Bypassing a longer segment of the gut may be more beneficial.
- Trial name
- NCT01514799
- Testing
- gastric bypass
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Aleris Obesity