Clinical trials: Severe Obesity
Morbid Obesity
Hunger/Satiety's Physiopathologic Study in Morbidly Obese Patients
The mechanisms that regulate appetite in the morbidly obese are multifactorial and not well-known. Different peripheral signals (such as ghrelin or cholecystokinin) play an important role in the central regulation of appetite and…
- Trial name
- NCT02414893
- Testing
- Sleeve gastrectomy
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari del Maresme
Respiratory Complication, Morbid Obesity
Does Residual Muscular Weakness Lead to an Increase in Respiratory Complications in Bariatric Patients?
The purpose of this study is to determine if residual weakness after weight loss surgery leads to an increased risk of respiratory complications in the postoperative period.
- Trial name
- NCT02037516
- Testing
- Accelomyography, Neostigmine, Qualitative Monitor
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Coastal Anesthesiology Consultants
Morbid Obesity
Treatment of Low Metabolic Rate Following Bariatric Surgery
Purpose is to determine the effect of ephedrine and caffeine, on metabolic rate and weight loss after bariatric surgery. Approximately 40% of patients struggle with their weight loss rate, or metabolic rate, after bariatric…
- Trial name
- NCT01596907
- Testing
- Ephedrine sulfate with caffeine, cellulose
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Oregon Weight Loss Surgery, LLC
Generalized Lipodystrophy
A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)
This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months.
- Trial name
- NCT06548100
- Testing
- mibavademab
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Regeneron Pharmaceuticals
Bariatric Surgery (Gastric Bypass), Severe Obesity
Gut Hormones as Mediators of Different Weight Loss Responses After Roux-en-Y Gastric Bypass
After gastric bypass, 10-20% of patients will obtain a suboptimal weight loss, often defined as <50% of the excess body weight. Exaggerated meal related secretion of gut hormones seem important for appetite reduction and…
- Trial name
- NCT02374632
- Testing
- Meal tests after saline injection, Meal tests after octreotide injection
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Hvidovre University Hospital
Obesity, Morbid
EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation
The risk of complication associated with airway in obese patient is important. The result of pre-oxygenation gives the clinician a prolonged non-hypoxic apnea time.
- Trial name
- EPO2-A (NCT02590406)
- Testing
- Beach chair (BC) and ZEEP, Reverse Trendelenburg and NIPPV
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Anastomotic Stricture, Morbid Obesity
Study of Proton Pump Inhibitors (PPI) to Prevent Strictures After Gastric Bypass Surgery
The purpose of this study is to determine whether suppressing acid production by administration of daily proton pump inhibitors in the early post-operative period will reduce the gastrojejunal anastomosis stricture rate in…
- Trial name
- NCT00361985
- Testing
- Esomeprazole
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Breast Cancer, Morbid Obesity
Effects of Bariatric Surgery on Breast Density Improvement and Impact on Breast Cancer Risk in Severe Obese Patients
Breast cancer is the most common cancer in women in the US, and obese women have a 20% to 40% increase in the risk of developing breast cancer compared with normal-weight women.
- Conditions
- Breast Cancer, Morbid Obesity, Bariatric Surgery Candidate
- Trial name
- NCT04170335
- Testing
- Bariatric surgery
- Where
- United States
- Sponsor
- The Cleveland Clinic
Morbid Obesity, Obesity
Resistance Training in Patients With Morbid Obesity
The researchers will conduct a study for avoiding the metabolic syndrome in morbid obese patients. Thus, the aim of the present will be determine the effects of a resistance training programme (RT) in preventing or attenuating…
- Conditions
- Morbid Obesity, Obesity, Physical Activity, Metabolic Syndrome
- Trial name
- ExinMO (NCT03921853)
- Testing
- Behavioral
- Where
- Chile
- Volunteers
- 39 people
- Sponsor
- Universidad de Los Lagos
Morbid Obesity
Effect of Exercise Before Gastric Bypass
Exercise training is proved to protect against premature cardiovascular mortality. Additionally there is evidence that relatively high exercise intensity may be an important factor for improving aerobic capacity and endothelial…
- Trial name
- NCT01042002
- Testing
- High intensity exercise
- Where
- Norway
- Volunteers
- 43 people
- Sponsor
- Norwegian University of Science and Technology
Morbid Obesity
Transmitted Light Tissue Thickness Analysis (TiLTT)
To assess gastric wall thickness using transmitted light intensity.
- Trial name
- TiLLT (NCT02749201)
- Testing
- Gastrisail
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Maimonides Medical Center
Metabolic Syndrome
The Effect of Bariatric/Metabolic Surgery on GFR
The purpose of this study is to determine the change in kidney function and blood pressure after gastric bypass versus conventional medical therapy in morbid obesity.
- Trial name
- NCT02406664
- Testing
- Bariatric surgery
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Hanyang University
Malnutrition; Diabetes, Malnutrition; Protein
Impact of Pea, Lentil and Oat Flour Particle Size on Glycemic Response in Healthy Adults
The study looks at the comparative effects of food products made with pea, lentil, and oat flour of various particle sizes on postprandial glycemic response, appetite and food intake, and amino acid release in healthy adults.
- Conditions
- Malnutrition; Diabetes, Malnutrition; Protein, Obesity
- Trial name
- PLO (NCT05291351)
- Testing
- Crackers made with whole, coarse, or fine pea and/or wheat flour, Crackers made with whole, coarse, or fine lentil and/or wheat flour, Porridge made with oat flour
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity
Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity
Approximately two thirds of the adult population in developed countries is categorized as over-weight or obese (BMI>30). In spite of worldwide increasing awareness, obesity is a major health concern.
- Trial name
- NCT01970202
- Testing
- 40mg Enoxaparin, 60mg Enoxaparin, Control
- Where
- Israel
- Volunteers
- 55 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Morbid Obesity
Six-month Study to Compare the Effects of Volume- and Pressure-Guided Adjustments on Weight Loss and Satiety
The purpose of this protocol is to determine how band fill volumes that are based on intraband pressure readings can influence the comfortability of the band and to compare weight loss with this methodology to weight loss with…
- Trial name
- NCT00960843
- Testing
- Intraband pressure recording system, Conventional Adjustment
- Where
- 2 sites in Australia, Czechia
- Volunteers
- 51 people
- Sponsor
- Ethicon Endo-Surgery
Gastro Esophageal Reflux, Severe Obesity
Comparison of Nissen-Sleeve and Gastric Bypass for GERD in Obese Patients
This randomized clinical trial aims to compare two surgical techniques for the treatment of obesity in patients who also have symptoms of gastroesophageal reflux disease (GERD).
- Conditions
- Gastro Esophageal Reflux, Severe Obesity, Bariatric Surgery
- Trial name
- SLEEVE-GERD (NCT07158008)
- Testing
- Nissen-Sleeve Gastrectomy (N-SG), Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG)
- Where
- Poland
- Volunteers
- 560 people
- Sponsor
- Jagiellonian University
Morbid Obesity
Population PK/PD of Propofol in the Morbidly Obese Patient
Rationale: The extreme increase of obesity in the last years had led to this study. There is no consensus about how to anaesthetise morbidly obese patients.
- Trial name
- NCT00395681
- Testing
- Diprivan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Morbid Obesity
Surgical Intervention in Bariatric Patients: Excess Weight Loss in the Morbidly Obese Following Gastric Plication
Up to 45 men and women who meet the entry criteria will undergo the gastric plication procedure. The study will assess subject excess weight loss (%EWL) following the study procedure at 1, 3, 6, 12, 18, 24, 30 and 36 months.
- Trial name
- NCT01077193
- Testing
- Gastric Plication
- Where
- 3 sites in United States, Czechia
- Volunteers
- 44 people
- Sponsor
- Ethicon Endo-Surgery
Diabetes, Morbid Obesity
Closed Incision Negative Pressure Wound Therapy vs. Foam as Post Operative Dressing
The primary objective is to assess the frequency of a wound healing complication, in a closed incisional wound in a "high risk" surgical incision when treated with Negative Pressure Wound Therapy versus a highly absorbent…
- Conditions
- Diabetes, Morbid Obesity, Lymphedema, Orthopedic Disorder
- Trial name
- NCT05427916
- Testing
- Avance Solo, Optifoam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Insulin Resistance, Proteomics
Proteomics in Morbid Obesity After Bariatric Surgery
Glycemic control is rapidly restored in patients with insulin resistance after bariatric surgery, in particular after the mal-absorptive one (i.e. Bilio-pancreatic diversion, BPD).
- Conditions
- Insulin Resistance, Proteomics, Morbid Obesity
- Trial name
- PROTOBESE (NCT01151917)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Catholic University of the Sacred Heart