Clinical trials: Severe Obesity
Morbid Obesity, Weight Reduction
Improving Patient Decisions About Bariatric Surgery
At least 15 million Americans are morbidly obese, or more than 100 pounds overweight. Medical treatments including drugs and behavior modification have proven ineffective in producing significant and lasting weight loss in this…
- Trial name
- PCORI (NCT02364128)
- Testing
- Decider Guider: Weight Loss
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Michigan
Morbid Obesity, Cesarean Delivery Affecting Fetus
Effect of CPAP on Fetal pH at Scheduled C-section in Morbidly Obese Women
The objective of our study is to evaluate the effect of CPAP on umbilical cord acid base status in morbidly obese women at the time of scheduled cesarean delivery.
- Trial name
- NCT04993651
- Testing
- CPAP
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Eastern Virginia Medical School
Morbid Obesity
GlideScope With EGRI Assessment in Obese Patients
BACKGROUND Unpredicted difficult tracheal intubation (DTI) with Macintosh laryngoscopy occurs frequently in obese patients. We investigated the incidence of DTI using the GlideScope® videolaryngoscope (GVL) with an algorithm…
- Trial name
- GLOBE (NCT02188979)
- Where
- Italy
- Volunteers
- 195 people
- Sponsor
- Università degli Studi di Brescia
Laparoscopic Surgery
Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass
This is a retrospective work on 200 morbid obese patients randomized and categorized into 2 groups according to the treatment method: the laparoscopic sleeve gastrectomy (LSG) and LRYGB groups, within the period from 2014 to 2019…
- Trial name
- NCT05145205
- Testing
- Sleeve gastrectomy, Laparoscopic Roux-en-Y gastric bypass
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University
Morbid Obesity
Effectiveness and Safety Study of LAP-BAND Treatment for Obese Adolescents
The purpose of this study is to determine whether the LAP-BAND system is safe and effective in morbidly obese adolescents.
- Trial name
- NCT00447590
- Testing
- LAP-BAND System
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Apollo Endosurgery, Inc.
Morbid Obesity, Weight Loss
Meal-induced Thrombin Generation Before and After Gastric Bypass
The purpose of this study is to investigate harmful effects of intentional weight loss. Intentional weight loss has been linked to increased risk of cardiovascular disease in overweight individuals, but the link between…
- Trial name
- NCT03176615
- Testing
- Experimental diet
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Surgery, Post-operative Pain
Laparoscopic Single Incision -Vs- Multiple Incision Gastric Band Surgery
A double blinded randomised control trial comparing the differences between laparoscopic single incision versus multiple port bariatric surgery in morbidly obese patients (BMI>35).
- Conditions
- Surgery, Post-operative Pain, Post-operative Recovery
- Trial name
- SIMIS (NCT01844960)
- Testing
- Single Incision Gastric Band Insertion, Multiple Incision Gastric Band Insertion
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- King's College Hospital NHS Trust
Obesity, Child
Sequencing of 14 Genes From Leptin Melanocortin Pathway in Severe Obesity in Childhood.
About 380 million children and adolescents suffer from overweight and obesity at the global level. Obesity results from the interplay between biological (sex, age, fetal programming, gut microbiota, epigenetics, and genetics) and…
- Trial name
- OBEGEN (NCT05938335)
- Testing
- sequencing of a panel of 14 genes in leptin melanocortin pathway
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Glucagon Like Peptide-1 (GLP-1, Delayed Gastric Emptying
GLP_1 RA Ultrasound Study
The purpose of the study is to determine whether patients taking GLP-1 RAs have increased residual (left behind), gastric (stomach), contents due to delayed gastric emptying when following standard preoperative fasting guidelines.
- Conditions
- Glucagon Like Peptide-1 (GLP-1, Delayed Gastric Emptying, Risk of Aspiration, Diabetes
- Trial name
- NCT06581120
- Testing
- Glucagon-Like Peptide-1 receptor agonists, Point of Care Gastric Ultrasound
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Morbid Obesity
Subcutaneous NTG for US Radial Artery Cannulation
Clinicians are increasingly dealing with morbid obese patients. In morbid obese patients, difficult sampling and problems encountered with noninvasive blood pressure monitoring makes arterial cannulation an essential skill in…
- Trial name
- NTG-US-art (NCT03006640)
- Testing
- Subcutaneous nitroglycrin, Subcutaneous saline
- Volunteers
- 60 people
- Sponsor
- AlRefaey Kandeel
Obesity (BMI > 35), Morbid Obesity
Predictive Value of Nutritional and Inflammatory Indices for Postoperative Complications After Bariatric Surgery
Bariatric surgery is an effective treatment for severe obesity, but postoperative complications remain an important cause of morbidity.
- Trial name
- BARI-NUTRI (NCT07747168)
- Testing
- Bariatric Surgery
- Where
- Greece
- Volunteers
- 600 people
- Sponsor
- G.Gennimatas General Hospital
Morbid Obesity
Changes in Incretines, Gut Hormones and Bile Acids After Roux-en-Y Gastric Bypass
Obesity is an increasing world wide problem. Moreover, the increase in patients who are considered morbidly obese is even higher (Sturm et al, Healt Aff 2004).
- Trial name
- NCT03384303
- Testing
- Standardized meal test
- Volunteers
- 10 people
- Sponsor
- Rijnstate Hospital
Morbid Obesity
Gastric Plication and Banding
The purpose of the study is to assess the efficacy of a hybrid laparoscopic surgical procedure for treatment of morbid obesity, Gastric Plication (G)) and Gastric Banding.
- Trial name
- GP and Band (NCT02072395)
- Testing
- Plication
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Ohio State University
Morbid Obesity
Endoscopic Sleeve Gastroplasty
The endoscopic sleeve gastroplasty allows stomach size reduction through an endoluminal suture approach without any incision. It could reduce the complications associated with current surgical techniques while obtaining the…
- Trial name
- Endosleeve (NCT02948621)
- Testing
- Endoscopic sleeve gastroplasty
- Where
- France
- Volunteers
- 80 people
- Sponsor
- IHU Strasbourg
Morbid Obesity, Weight Loss
Efficacy of a Mobile Application to Help in Weight Loss Before Bariatric Surgery
The present randomized clinical trial aims to prove the safety and efficacy of an interactive mobile application (Care4Today®) to obtain sufficient weight loss and empower patients with morbid obesity before being submitted to a…
- Trial name
- VAMOS (NCT05598840)
- Testing
- Care4Today APP: multimodal digital prehabilitation programme for candidates undergoing bariatric surgery., Very low calory diet
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Hospital Universitari de Bellvitge
Sleep Apnea, Obstructive, Obesity
A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight
The purpose of the studies is to evaluate the efficacy and safety of eloralintide in participants with moderate-to-severe obstructive sleep apnea and obesity or overweight.
- Conditions
- Sleep Apnea, Obstructive, Obesity, Overweight
- Trial name
- ENLIGHTEN-3 (NCT07369011)
- Testing
- Eloralintide
- Where
- 115 sites in United States, Australia and 9 more
- Volunteers
- 800 people
- Sponsor
- Eli Lilly and Company
Severe Mental Disorder, Obesity
Health Education Programme Through Physical Exercise for People With Severe Mental Disorders
The goal of this clinical trial is to [learn about, test, compare etc.] in individuals with severe mental disorders and obesity comorbid.
- Trial name
- HEPPE-PSMI (NCT06069739)
- Testing
- Guided physical activity, Standard physical activity
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Obstructive Sleep Apnea, Obesity
Impact of Smoking, Benzodiazepine (BZD) Use and Obesity on Severe Obstructive Sleep Apnea (sOSA)
In this study the investigators will analyze the influence of smoking, benzodizepine use, and obesity among patients with severe Obstructive Sleep Apnea (sOSA).
- Conditions
- Obstructive Sleep Apnea, Obesity, Smoking
- Trial name
- NCT02539264
- Testing
- Smoking, Obesity, Benzodiazepine use
- Volunteers
- 920 people
- Sponsor
- Astes
Morbid Obesity
GERD Following Laparoscopic Sleeve Gastrectomy
Laparoscopic Sleeve Gastrectomy (LSG) creates a vertical gastrectomy which results in a narrow and tubular shape of stomach. The line of resection starts at 3-6 cm. from pylorus (antrum) toward to the angle of His.
- Trial name
- NCT02476474
- Testing
- 3 cm start of resection, 6 cm start of resection
- Sponsor
- University of California, San Francisco
Obesity, Gastric Reflux
The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
The objective of this study is to investigate the effect of Esomeprazol administered in tablets (Esomeprazol MUT Sandoz® 40mg) or in solution (Esomeprazol MUT Sandoz® 40mg in 10ml tap water) on acid production in the gastric…
- Conditions
- Obesity, Gastric Reflux, Ulcer, Gastric
- Trial name
- NCT05320796
- Testing
- upper endoscopy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Prof Urs Zingg