Clinical trials: Severe Obesity
Morbid Obesity, High BMI
Efficacy Of Quadratus Lumborum II Block For Laparoscopic Sleeve Gastrectomy
The QL 2 block is a novel fascial plane block recently described by Blanco and colleagues in which local anesthetic is deposited adjacent to the antero-lateral aspect of the quadratus lumborum muscle.
- Trial name
- NCT04073056
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity, Morbid
Safety and Effectiveness Study of The Swedish Adjustable Gastric Band (SAGB) in the Treatment of Morbid Obesity
The purpose of this study is to determine whether the Swedish Adjustable Gastric Band (SAGB) is safe, and effective in achieving weight loss in patients with Morbid Obesity.
- Trial name
- NCT00166205
- Testing
- Swedish Adjustable Gastric Band
- Where
- 12 sites in United States
- Volunteers
- 276 people
- Sponsor
- Ethicon Endo-Surgery
Bariatric Surgery Candidate
Assessment of Knee Arthrosis After Bariatric Surgery
Impact of loss of weight on knee arthrosis has not been thoroughly studied. The primary goal of this study is to compare the MRI parameters (aspect of cartilage and oedema of spongious sub-chondral bone) before and one year after…
- Trial name
- BASIK (NCT01207024)
- Testing
- knee MRI
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation, Morbid Obesity
Bariatric Atrial Restoration of Sinus Rhythm
The objective of this study is to determine whether bariatric surgery followed by Atrial Fibrillation (AF) catheter ablation is superior to AF catheter ablation alone in the management of atrial fibrillation in patients with…
- Trial name
- BAROS (NCT04050969)
- Testing
- Bariatric surgery, Atrial Fibrillation (AF) Catheter Ablation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Obesity
Bariatric Surgery Combined With GLP-1 Receptor Agonists Study
Obese patients exhibit considerable heterogeneity and complex comorbidities, making long-term effective management challenging with single therapies.
- Trial name
- BS-GLP (NCT07336862)
- Testing
- BS-GLP group, BS group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China-Japan Friendship Hospital
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea
This trial is conducted in North America. The aim of the trial is to investigate the effect of liraglutide in obese subjects with sleep apnoea.
- Conditions
- Metabolism and Nutrition Disorder, Obesity, Obstructive Sleep Apnoea
- Trial name
- NCT01557166
- Testing
- liraglutide
- Where
- 42 sites in United States, Canada
- Volunteers
- 359 people
- Sponsor
- Novo Nordisk A/S
Morbid Obesity
Laparoscopic Sleeve Gasterectomy With or Without Pyloric Botulinum Neurotoxin Injection
Leakage is the most common complication after laparoscopic sleeve gastrectomy which may amount to 20% in some studies. We hypothesize that Clostridium botulinum neurotoxin A (BTX-A) injection into the pyloric sphincter during the…
- Trial name
- NCT02325141
- Testing
- laparoscopic sleeve gastrectomy
- Volunteers
- 130 people
- Sponsor
- Mansoura University
Severe Obesity, Type 2 Diabetes
SLEEVEDIAB To Explore the Early and Late Metabolic Effects of Sleeve Gastrectomy in Obese Patients
Sleeve gastrectomy is a restrictive procedure based on the removal of a large part of the gastric fundus. According to a recent randomized study, weight loss and resolution of diabetes are comparable to that obtained after…
- Trial name
- SLEEVEDIAB (NCT02076880)
- Testing
- Caloric restriction, No caloric restriction
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Montpellier
Morbid Obesity
Tai Chi as Physical Activity for Women With Morbid Obesity
This study investigated the use of Tai Chi as a feasible form of physical activity for women with morbid obesity utilizing an instructional digital video disc (DVD).
- Trial name
- NCT04106661
- Testing
- Tai Chi
- Volunteers
- 17 people
- Sponsor
- Husson University
Severe Obesity
VLCD by Enteral Route for Weight Loss
Body weight excess, from overweight to overt obesity, is associated with adverse health outcomes. In view of the time-trends of the obesity epidemic and the related cost burden, the search for effective strategies for weight…
- Trial name
- NEP (NCT01965990)
- Testing
- NEP
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- San Giuseppe Moscati Hospital
Severe Obesity, Hypoxia
Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
The study evaluated the effect of non-invasive positive pressure ventilation (NIPPV) to decrease the incidence of desaturation events in patients with severe obesity undergoing upper endoscopy.
- Trial name
- NCT03529461
- Testing
- Non-invasive positive pressure ventilation through nasal mask, Rescue non-invasive positive pressure ventilation through nasal mask, Secondary rescue maneuvers
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol Hospital
Obesity
Central Nervous Processing of Visual Food Stimuli in Severely Obese Subjects
Recent evidence has pointed to distinct alterations of brain functions in obese subjects some of which may even be causative for their obesity.
- Trial name
- NCT01493583
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- Cantonal Hospital of St. Gallen
Severe Obesity
Sprayshield as Adhesion Barrier System for Obese Patients
The application of SprayShield during a laparoscopic band removal (first surgical step) will be evaluated to see if the postoperative adhesions between the stomach, the left liver and the diaphragm are not severe, facilitating…
- Trial name
- Sprayshield (NCT02142660)
- Testing
- ablation of gastric
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Morbid Obesity, Non Alcoholic Steatohepatitis
Non Invasive Measurements of Fibrosis, Inflammation and Steatohepatitis in Morbidly Obese Patients
Abstract: Fatty liver most frequently corresponds to a fat overload of the liver. It is usually classified as alcoholic steatosis or non-alcoholic steatosis.
- Trial name
- FIRM (NCT01695083)
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Morbid Obesity
Sleeve Gastrectomy Outcomes With Different Stapling Devices
Sleeve gastrectomy is now the most commonly performed bariatric surgery. While many studies have evaluated factors that may minimize post-operative hemorrhage and staple-line leak, the investigators are unaware of any studies…
- Trial name
- NCT02731079
- Testing
- Covidien iDrive, Ethicon Echilon
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Edna Rath
Morbidly Obese
Use of Breath Stacking Technique on Regional Ventilation in Box Chest in Women With Morbid Obesity
Objectives: To evaluate the effects of the technique of Breath Stacking (BS) in the distribution of ventilation in the chest in women with morbid obesity.
- Trial name
- NCT01551277
- Testing
- BREATH STACKING
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Pernambuco
Obesity, Morbid Obesity
Safety and Efficacy of Lean Body Weight-based IV Heparin Dosing in Obese/Morbidly Obese Patients
Standard weight-based IV heparin for normal weight patients is based on actual body weight (ABW). However, no well-defined guidelines have been established for patients considered to be obese or morbidly obese.
- Conditions
- Obesity, Morbid Obesity, Venous Thromboembolism, Atrial Fibrillation
- Trial name
- NCT01363193
- Testing
- Lean Body Weight-based heparin dose
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nazareth Hospital
Cardiovascular Risk, Obesity
A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
This clinical study is being conducted to evaluate the safety and effectiveness of zenagamtide in people with atherosclerotic cardiovascular disease (ASCVD) and excess body weight compared with placebo.
- Trial name
- AMBIENCE (NCT07861100)
- Testing
- Zenagamtide
- Where
- 769 sites in United States, Argentina and 24 more
- Volunteers
- 8,500 people
- Sponsor
- Novo Nordisk A/S
Knee Osteoarthritis, Morbid Obesity
Optimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial
Does weight loss surgery in patients with morbid obesity prior to knee replacement surgery improve outcomes from knee replacement surgery
- Trial name
- OMEOSKO (NCT05120492)
- Testing
- bariatric surgery followed by total knee replacement
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis of Knee, Arthroplasties, Knee Replacement
Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?
The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery.
- Conditions
- Osteoarthritis of Knee, Arthroplasties, Knee Replacement, Sleeve Gastrectomy
- Trial name
- NCT06767787
- Testing
- laparoscopic sleeve gastrectomy, total knee arthroplasty
- Where
- 2 sites in Canada
- Volunteers
- 142 people
- Sponsor
- Memorial University of Newfoundland