Clinical trials: Severe Obesity
Obesity, Emotional Trauma
Effects of EMDR Therapy in Patients With Severe Obesity
The aims of the study are to perform psychological intervention using EMDR Therapy (Eye Movement Desensitization and Reprocessing Therapy) in the preoperative period, evaluate the personality of each patient through the PFB test…
- Trial name
- NCT03555110
- Testing
- Personality Factor Battery Test (PFB Test), Eye Movement Desensitization and Reprocessing Therapy (EMDR)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Obesity
Kidney Function Indexed Extracellular Volume Before and After Obesity Surgery
Obesity promotes chronic kidney disease and is accelerating its shift to the stage of renal replacement. Bariatric surgery is a treatment for severe or morbid obesity whose renal benefit is currently unknown.
- Trial name
- NCT02830646
- Testing
- DFG mesure
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Morbid Obesity
Accelerated Aging of the Cells of Visceral Adipose Tissue in Morbid Obese Subjects
Numerous epidemiological studies clearly showed the relationship between the excessive growth of visceral adipose tissue and risk of developing insulin resistance, type 2 diabetes and other cardiovascular risk factors.
- Trial name
- SENAPID (NCT01525472)
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Lysosomal Acid Lipase Deficiency, Obesity
Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
The very low carbohydrates diet (VLCKD) induces liver steatosis amelioration. Lysosomal acid lipase (LAL) deficiency plays a role in fats accumulation in liver. To date, no studies have assessed LAL activity in morbid obesity.
- Conditions
- Lysosomal Acid Lipase Deficiency, Obesity, Ketogenic Dieting, Ketosis
- Trial name
- NCT03564002
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Obesity
Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity
Approximately two thirds of the adult population in developed countries is categorized as over-weight or obese (BMI>30). In spite of worldwide increasing awareness, obesity is a major health concern.
- Trial name
- NCT01970202
- Testing
- 40mg Enoxaparin, 60mg Enoxaparin, Control
- Where
- Israel
- Volunteers
- 55 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Morbid Obesity
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity
The purpose of this study is to quantify the relative contribution of improved insulin sensitivity and improved insulin secretion to the glycaemic effect of bariatric surgery.
- Trial name
- NCT01063127
- Testing
- Study on insulin sensitivity after diet or bariatric surgery, gastric bypass
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Catholic University of the Sacred Heart
Obesity, Post-gastric Bypass
Nutritional Effect of an Amino Acid Mixture on Lean Body Mass (LBM) in Post-bariatric Surgery Patients
The Focus of this study is to look at the role of nutrition in maintaining lean body mass post-gastric bypass surgery. The purpose of this study is to test whether LBM is increased in those patients receiving a nutritional…
- Trial name
- NCT00473356
- Testing
- receive amino acid supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Morbid Obesity
Oxygenation Test During General Anesthesia
The study investigates if applying a special ventilatory strategy during anesthesia for laparoscopic gastric by pass, produces less atelectasis and better oxygenation in spite of using 100 % oxygen during pre oxygenation and…
- Trial name
- NCT01559402
- Testing
- CPAP and 100% oxygen, CPAP and 31% oxygen, No CPAP and 100% oxygen
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Västmanland
Obesity, Morbid, Extubation Failure
Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing.
- Trial name
- NCT05918575
- Testing
- Noninvasive ventilation alternating with high flow nasal cannula, High flow nasal cannula
- Where
- 5 sites in United States, Mexico
- Volunteers
- 250 people
- Sponsor
- Rush University Medical Center
Pain, Postoperative
Dexmedetomidine Versus Fentanyl on Postoperative Analgesic Profile in Laparoscopic Sleeve Gastrectomy
Dexmedetomidine (Dex) activates the α2 adrenergic receptor that is present within the locus coeruleus, leading to anxiolysis, hypnosis, analgesia, and sedation.
- Trial name
- NCT06186895
- Testing
- Dexmedetomidine, Fentanyl
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Helwan University
Fetus Fetus, Pregnancy Complications
the Fetal Epicardial Thickness in Obese Pregnant Women (EFT)
the effects of fetal EFT on fetal cardiac function and fetal and maternal outcomes were investigated in obese pregnant women compared with normal-weight pregnant women.
- Trial name
- EFT (NCT05948319)
- Testing
- Doppler ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Asthma
Pulmonary Rehabilitation for Uncontrolled Asthma Associated With Elevated BMI
Aim to evaluate the impact of a pulmonary rehabilitation (rehab) programme tailored and delivered to overweight and obese patients with difficult asthma on: 1.
- Trial name
- PRODA01 (NCT03630432)
- Testing
- Pulmonary rehabilitation, Usual Care
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- NHS Greater Glasgow and Clyde
Obesity, Obesity, Morbid
Weight Loss and Aggression
Obesity has become an important medical and social problem in western countries today. Although many surgical procedures are performed for obesity, Laparoscopic sleeve gastrectomy (LSG) has become the most common bariatric…
- Conditions
- Obesity, Obesity, Morbid, Aggression
- Trial name
- NCT05654584
- Testing
- laparoscopic sleeve gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Obesity & Overweight, Sleeve Gastrectomy
Istmin Levels in Laparoscopik Sleeve Gastrectomy
Obesity is a multifactorial disease which has become a public health problem with increasing frequency, especially in recent years.
- Conditions
- Obesity & Overweight, Sleeve Gastrectomy, Adipokines
- Trial name
- NCT07335549
- Testing
- Preoperative Serum Isthmin Levels, Postoperative Third Month's Serum Isthmin Levels, Preoperative BMI
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Bariatric Surgery Candidate
Pharmacokinetics and Pharmacodynamics of Edoxaban Before and After Bariatric Surgery
The study will be conducted at a single site in the Canada, Quebec. Participants will be recruited from the bariatric surgery clinic and will be required to be either, waiting for sleeve gastrectomy surgery (n=12, restrictive…
- Trial name
- EXPOSE (NCT06326138)
- Testing
- Edoxaban Pharmacokinetics and Pharmacodynamics
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Overweight, Diabetes Type 2
The Efficacy of Bariatric Surgery Compared to Medical Therapy in Controlling Type2 Diabetes Mellitus in Patients With Non Morbid Obesity.
The growing incidence of obesity and type2 DM globally is widely recognized as one of the most challenging contemporary threats to public health.
- Trial name
- NCT02036138
- Testing
- Laparoscopic Sleeve Gastrectomy, Laparoscopic Roux-en-Y Gastric Bypass, Advanced Medical Therapy
- Where
- Israel
- Volunteers
- 76 people
- Sponsor
- Hadassah Medical Organization
Epidural Anesthesia, Spinal Ultrasound
Utility of Ultrasound in Identification of Midline and Placement of Epidural in Severely Obese Parturients
This study will address the utility of ultrasound in the placement of an epidural catheter in severely obese parturients. Identification of midline can often be difficult using the standard method of palpation in obese patients.
- Conditions
- Epidural Anesthesia, Spinal Ultrasound, Obesity
- Trial name
- NCT03100968
- Testing
- Palpation, Ultrasound
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Morbid Obesity
A Study of Clinical Outcomes of the REALIZE Adjustable Gastric Band-C
The purpose of this study is to evaluate the results patients are obtaining with the Realize™ Adjustable Gastric Band-C during the first 24 months after surgery.
- Trial name
- NCT00999661
- Where
- 7 sites in United States
- Volunteers
- 231 people
- Sponsor
- Ethicon Endo-Surgery
Morbid Obesity
Effect of Liraglutide on Weight Loss in Patients Who Have Undergone Revisional Bariatric Surgeries.
Our primary objective is to assess the effect of Liraglutide on weight loss in patients who have undergone secondary bariatric surgeries.
- Trial name
- NCT05285397
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Obesity, Morbid
ECG Triggered Dual Source CT for Non-invasive Pre-operative Cardiac Imaging in Morbid Obese Patients
Coronary arterial disease is a risk factor for bariatric surgery and might be a predictor for later major adverse coronary events.
- Trial name
- NCT02802579
- Testing
- standard protocol, enhanced protocol, enhanced obesity protocol
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Cantonal Hospital of St. Gallen