Clinical trials: Severe Septic Syndrome
Severe Sepsis, Septic Shock
Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis
The purpose of this study is to determine whether BMS-936559 is safe and has the desired pharmacologic activity in patients who have severe sepsis.
- Trial name
- NCT02576457
- Testing
- BMS-936559
- Where
- 13 sites in United States
- Volunteers
- 35 people
- Sponsor
- Bristol-Myers Squibb
Escalation of Care, Cardiopulmonary Arrest
Early Warning System for Clinical Deterioration on General Hospital Wards
The goal is to develop a two-tiered monitoring system to improve the care of patients at risk for clinical deterioration on general hospital wards (GHWs) at Barnes-Jewish Hospital (BJH).
- Conditions
- Escalation of Care, Cardiopulmonary Arrest, Respiratory Arrest, Severe Sepsis
- Trial name
- NCT01280942
- Testing
- EWS Nursing Alerts, Wireless Remote Sensor
- Where
- United States
- Volunteers
- 20,031 people
- Sponsor
- Washington University School of Medicine
Sepsis, Severe Sepsis
Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study
The primary objective is to demonstrate that the plasma inducible nitric oxide synthase (iNOS) assay (PliNOSa® test) has an acceptable relative risk ratio for predicting the onset of sepsis within 72 hours of testing when…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- PliNOSa® Test (NCT01371929)
- Volunteers
- 166 people
- Sponsor
- Research & Diagnostic Antibodies
Critical Illness, Sepsis, Severe
Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm
The inflammatory storm in critically ill patients releases cytokines, causing systemic immune damage, which may be an important cause of multiple organ failure and even death.
- Trial name
- NCT04850456
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Severe Sepsis and Septic Shock
Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance
Microparticules (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with merging role in pathophysiology of immune and…
- Trial name
- NCT02391792
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Severe Sepsis, Septic Shock
Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations.
- Trial name
- NCT01332734
- Testing
- Magnesium Sulfate
- Where
- Lithuania
- Volunteers
- 14 people
- Sponsor
- Frisius Medisch Centrum
Severe Sepsis, Septic Shock
Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis
The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients.
- Trial name
- NCT00541827
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Severe Sepsis, Septic Shock
Investigate the Activity of Endotoxin in Severe Sepsis
Endotoxin is the major mediator of gram-negative bacteria which cause the systemic inflammation and result in microcirculatory dysfunction, and it leads to multiple organ dysfunction and death in patients with severe sepsis and…
- Trial name
- NCT01957254
- Where
- Taiwan
- Volunteers
- 2 people
- Sponsor
- National Taiwan University Hospital
Anesthesia, Endothelial Dysfunction
Effect of Fluid Challenge on Glycocalyx
Interventional study comparing effect of two regimes of fluid challenge in patients with sepsis and in patients undergoing elective major surgery on glycocalyx by using perfused Boundary Region in sublingual microcirculation.
- Conditions
- Anesthesia, Endothelial Dysfunction, Sepsis, Septic Shock
- Trial name
- NCT03891342
- Testing
- Fluid bolus administration
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Hradec Kralove
Hemophagocytic Lymphohistiocytosis
Comparison of Two Etoposide Initiation Strategies for Severe Hemophagocytic Lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH) is an immune-mediated disorder characterized by hyperactivation of the immune system, leading to a cytokine storm responsible for organ failures.
- Trial name
- TIC-TAC-SAM (NCT07497438)
- Testing
- Etoposide (Early strategy), Etoposide (Delayed strategy)
- Where
- France
- Volunteers
- 176 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Septic Shock
Treatment of Severe Infection With Antihyperlipidemia Drug
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors increase LDL receptors by decreasing its degradation. In sepsis the pathogenic substances, endotoxin, lipoteichoic acid, phospholipomannan are the main cause of the…
- Trial name
- NCT03634293
- Testing
- Alirocumab Injectable Product, Saline Solution
- Where
- Israel
- Volunteers
- 712 people
- Sponsor
- Wolfson Medical Center
Sepsis, Severe Sepsis
Vitamin D Status in Patients With Severe Sepsis
Sepsis is a clinical entity that complicates infection. Without early recognition and timely management, it can rapidly progress to severe sepsis, septic shock, and culminate in multiple organ dysfunction syndrome.
- Conditions
- Sepsis, Severe Sepsis, End Organ Damage, Multi Organ Failure
- Trial name
- ViDISS (NCT02684487)
- Testing
- vitamin D3
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Severe Sepsis, Septic Shock
Volume Replacement With Albumin in Severe Sepsis
BACKGROUND The association between mortality and hypoalbuminemia has been observed in several diseases. Nonetheless, the efficacy of albumin on survival in critically ill patients is controversial.
- Trial name
- ALBIOS (NCT00707122)
- Testing
- Albumin and Crystalloids, Crystalloids
- Where
- Italy
- Volunteers
- 1,818 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Severe Sepsis
Investigation of Correlation Between Interstitial and Arterial Blood Glucose Concentrations in Septic Patients
This is a mono-centre trial performed at the medical ICU at the Medical University Graz. There will be a study visit (V1) and a follow-up assessment (V2).
- Trial name
- NCT00463645
- Testing
- microdialysis, microperfusion
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Sepsis, Severe
Recombinant Interleukin-7 (CYT107) to Restore Absolute Lymphocyte Counts in Sepsis Patients
This phase II randomized study will assess the effect of receiving IV recombinant human IL-7 (CYT107) versus placebo in lymphopenic sepsis patients The aim is to confirm the immune cell reconstitution observed in other studies…
- Trial name
- IRIS-7-C&D (NCT03821038)
- Testing
- CYT107
- Where
- 10 sites in United States, France
- Volunteers
- 21 people
- Sponsor
- Revimmune
SARS-CoV 2, COVID19
Prevention and Treatment With Calcifediol of COVID-19 Induced Acute Respiratory Syndrome
The administration of Calcifediol in patients with COVID-19, will reduce the development of SARS and the worsening of the various phases of the syndrome.
- Conditions
- SARS-CoV 2, COVID19, SARS (Severe Acute Respiratory Syndrome), Cytokine Release Syndrome
- Trial name
- COVIDIOL (NCT04366908)
- Testing
- BAT + Calcifediol, BAT
- Where
- Spain
- Volunteers
- 517 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Cardiac Arrest, Renal Failure
The Vital Signs to Identify, Target, and Assess Level (VITAL) Care Study III
To evaluate the effect of automated recording on frequency of recorded scores, number of automated notifications and serious events.
- Conditions
- Cardiac Arrest, Renal Failure, Respiration Failure, Myocardial Infarction
- Trial name
- NCT02973243
- Testing
- Automatic RR Measurement
- Where
- United Kingdom
- Volunteers
- 446 people
- Sponsor
- Philips Healthcare
Sepsis, Severe
Effect of Probiotics on Cytokines in Sepsis in Children
To assess the effect of probiotics on cytokine's level(interleukin 6 and Transforming growth factor-β1)in children admitted to PICU with sepsis.
- Trial name
- NCT05467605
- Testing
- probiotics( Lactobacillus acidophilus, lactobacillus delbruekii and lactobacillus fermentum 10 billions),, maltose dissolved in distilled water
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Sepsis
Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis
Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU…
- Trial name
- Aminoside_II (NCT02898961)
- Testing
- 30 mg/kg amikacin or 8 mg/kg gentamicin
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Severe Sepsis, Septic Shock
Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock
The purpose of this study is to determine the effect of the intensive insulin therapy on coagulation and fibrinolysis in patients affected by severe sepsis and septic shock.
- Trial name
- NCT00159952
- Testing
- intensive insulin therapy
- Where
- 3 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Policlinico Hospital