Clinical trials: Severe Septic Syndrome
Sepsis, Severe Sepsis
RCT of Sepsis Machine Learning Algorithm
The focus of this study will be to conduct a prospective, multi-center randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a machine-learning…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03882476
- Testing
- InSight
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dascena
Sepsis, Severe Sepsis
Simplified Severe Sepsis Protocol-2 (SSSP-2) in Zambia
This study is a randomized control trial assessing the impact of a simple evidence-based protocol for the treatment severe sepsis with hypotension in Zambia.
- Conditions
- Sepsis, Severe Sepsis, Tuberculosis
- Trial name
- SSSP-2 (NCT01663701)
- Testing
- Simplified severe sepsis protocol, Usual care
- Where
- Zambia
- Volunteers
- 212 people
- Sponsor
- Vanderbilt University
Covid19, SARS-CoV 2 Infection
Effect of Local Treatment(Carrageenan Nasal Spray and PVP-I Mouthwash) in Reducing Viral Load in Patients With COVID-19
The goal of this study is to recruit confirmed Covid-19 patients, to evaluate whether the topical anti-septic can improve clinical outcome in early Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection.
- Trial name
- LT-COVID19 (NCT05049213)
- Testing
- Carrageenan nasal spray and 1% PVP- mouthwash and gargle
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Sepsis, Severe Sepsis
The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis
The scope of this clinical study is to evaluate the possible role of an enteral formulation enriched with EPA, GLA and Antioxidants in patients diagnosed in the early stages of sepsis despite mechanical ventilation requirements…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT00329680
- Testing
- Eicosapentaenoic acid, Gamma-Linolenic Acid and Antioxidant Vitamins, Standard ICU enteral diet, isocaloric to the study diet
- Where
- 12 sites in Brazil
- Volunteers
- 115 people
- Sponsor
- Fernandes Tavora Hospital
Obesity, Abdominal, Surgery
Perioperative Blood Adiponectin Dynamics and Systemic Infflamatory Response After Major Colorectal Surgery
Surgical stress after major abdominal surgery in perioperative period causes neuroendocrine, metabolic and imunologic changes in organism with production of proinfflamatory citokines and results with appearance of systemic…
- Conditions
- Obesity, Abdominal, Surgery, Systemic Inflammatory Response Syndrome, Postoperative Complications
- Trial name
- ADIPOS (NCT06057207)
- Testing
- serum levels of adiponectin, IL-6, Postoperative systemic infflamation
- Where
- 2 sites in Croatia
- Volunteers
- 58 people
- Sponsor
- Osijek University Hospital
Initial Phase of Severe Sepsis and Septic Shock
Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem During the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units
This is a prospective, noncomparative study to assess the pharmacodynamics of meropenem during early phase of severe sepsis and septic shock in critically ill patients in an intensive care unit.
- Trial name
- NCT02213796
- Testing
- Meropenem
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Sutep Jaruratanasirikul
Trauma, Sepsis
Prediction Study of Complications After Severe Trauma
The purpose of this study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of post-traumatic complications in a multicenter sample of severe trauma patients.
- Conditions
- Trauma, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- PSCAT (NCT01713205)
- Where
- 6 sites in China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Jiang Jianxin
Acute Kidney Injury, Severe Sepsis
Acute Kidney Injury in Septic Critically Ill Patients : Are Aminoglycosides Really Harmful?
The purpose of the present study is to determine whether administration of aminoglycosides in septic critically ill patient is a risk factor for acute kidney injury
- Trial name
- REAMICHOC (NCT01932814)
- Where
- France
- Volunteers
- 317 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Mesenchymal Stromal Cells, Remestemcel-L
MSCs in COVID-19 ARDS
The mortality rate in SARS-CoV-2-related severe ARDS is high despite treatment with antivirals, glucocorticoids, immunoglobulins, and ventilation.
- Conditions
- Mesenchymal Stromal Cells, Remestemcel-L, Acute Respiratory Distress Syndrome, COVID
- Trial name
- NCT04371393
- Testing
- Remestemcel-L
- Where
- 21 sites in United States
- Volunteers
- 223 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Severe Sepsis
Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy - Observational Long-term Outcome Follow up
Subjects previously enrolled / randomized in the ReActIF-ICE (Recovery from acute immune failure in septic shock by immune cell extracorporeal terapy - immune competence enhancement) study received either standard sepsis…
- Trial name
- ReActIF- LTO (NCT06143137)
- Where
- 2 sites in Germany
- Volunteers
- 142 people
- Sponsor
- Artcline GmbH
Sepsis, Hemorrhage Brain
DetectIon of Severe Sepsis In PATients With Neurological haemorrhagE (The DISSIPATE Study)
The research study is to explore novel early predictors and validation of laboratory parameters in the management of sepsis in critically ill patients especially with brain injuries and systemic inflammatory response syndrome…
- Trial name
- DISSIPATE (NCT04624945)
- Testing
- APTT CWA (Activated partial thromboplastin time clot waveform analysis), Procalcitonin and Serological/Inflammatory markers (KL-6, SPA, MIG, Presepsin)
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Pneumonia, Severe Acute Respiratory Syndrome
Best Supportive Care With or Without Low Dose Whole Lung Radiation Therapy for the Treatment of COVID-19
This phase III trial compares low dose whole lung radiation therapy to best supportive care plus physicians choice in treating patients with COVID-19 infection.
- Conditions
- Pneumonia, Severe Acute Respiratory Syndrome, Symptomatic COVID-19 Infection Laboratory-Confirmed
- Trial name
- RESCUE1-19 (NCT04433949)
- Testing
- Best Practice, Low Dose Radiation Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Sepsis, Shock
The Effect of Erythropietin on Microcircualtory Alteration in Intensive Care Unit Patients With Severe Sepsis
The objective of this study is to determine if observations the investigators made in an animal model of sepsis can be translated to clinical practice.
- Trial name
- NCT01087450
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- London Health Sciences Centre
Severe Sepsis
Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial
The ARISE RCT is a multi-centre, randomised, controlled trial of EGDT compared to standard care in patients with severe sepsis presenting to the ED.
- Trial name
- ARISE (NCT00975793)
- Testing
- Early Goal Directed Therapy (EGDT)
- Where
- 51 sites in Australia, Finland and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Belinda Howe
Community-acquired Pneumonia, Severe Pneumonia
Fulminant Severe CAP - an Observational Study
Severe community-acquired pneumonia (CAP) represents a major cause of hospital mortality. Among severe CAP cases, some exhibit a rapidly progressive evolution, leading to severe ARDS/acute respiratory failure and septic shock…
- Conditions
- Community-acquired Pneumonia, Severe Pneumonia, ARDS, Human, Sepsis
- Trial name
- FULMISCAP (NCT06516601)
- Testing
- no intervention
- Where
- 2 sites in Italy
- Volunteers
- 1,460 people
- Sponsor
- University of Trieste
Covid19
Survival TRial Using CytoKines in COVID-19 (STRUCK Trial)
Currently, there are few approved treatments for COVID-19, antiretroviral (remdesivir) and corticoids. With about 15% of COVID-19 patients suffering from severe disease health system will be overwhelmed.
- Trial name
- STRUCK (NCT04724629)
- Testing
- Ixekizumab, Aldesleukin, Colchicine
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Sepsis Severe, Septic Shock
Assessment for Implementation Methods in Sepsis
Since the introduction of sepsis bundles, there have been multiple published trials that have demonstrated a consistent, strong association between implementation of sepsis "bundles" (3-hour bundle) and improved survival.
- Trial name
- AIMS (NCT05491941)
- Testing
- Sepsis Bundle
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Rhode Island Hospital
Severe Sepsis, Emergency
Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery
This study wants to compared the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in septic patients requiring emergency surgery.
- Conditions
- Severe Sepsis, Emergency, Surgery
- Trial name
- NCT01654003
- Testing
- CONTROL, OPTIMIZED
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Sepsis, Septic Shock
An Algorithm Driven Sepsis Prediction Biomarker
A sepsis early warning predictive algorithm, InSight, has been developed and validated on a large, diverse patient cohort. In this prospective study, the ability of InSight to predict severe sepsis patients is investigated.
- Conditions
- Sepsis, Septic Shock, Severe Sepsis
- Trial name
- NCT03015454
- Testing
- Severe Sepsis Prediction, Severe Sepsis Detection
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Dascena
Sepsis, Severe
Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy
Evaluation of a novel therapy approach for severe sepsis patients. Subjects randomized into the treatment arm receive treatment with an immune cell perfusion system on top of standard care.
- Trial name
- ReActiF-ICE (NCT05442710)
- Testing
- ARTICE
- Where
- 20 sites in Germany
- Volunteers
- 142 people
- Sponsor
- Artcline GmbH