Clinical trials: Severe Stroke
Severe Stroke, Acute Stroke
Controlling Hypertension After Severe Cerebrovascular Event
The purpose of this academic lead study is to explore ideal blood pressure targets and optimum individualized anti-hypertension strategies in acute severe stroke.
- Conditions
- Severe Stroke, Acute Stroke, Hypertension
- Trial name
- CHASE (NCT02982655)
- Testing
- Individualized BP lowering
- Where
- 26 sites in China
- Volunteers
- 500 people
- Sponsor
- Xijing Hospital
Severe Stroke
Delayed Versus Early Antihyperglycemic Treatment for Severe Stroke
This study is a exploratory, randomized, controlled, open-label, blinded-endpoint Phase II clinical trial designed to evaluate whether delaying antihyperglycemic treatment for 72 hours improves neurological outcomes in patients…
- Trial name
- NCT07501533
- Testing
- Intravenous insulin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Stroke
Effects of Device-assisted Practice of ADL on Arm/Hand Recovery in Individuals With Moderate to Severe Stroke
A large number of post-stroke survivors cannot functionally use their paretic upper extremity (UE). This study therefore investigates effects of device-assisted practice of activities of daily living (ADL) in a close-to-normal…
- Trial name
- NCT04077073
- Testing
- ReIn-Hand, Robot
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Northwestern University
Asymptomatic, Artery
Stenting Versus Best Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis
Background. Carotid artery stenting (CAS) recently has become an accepted method for treatment of patients with high-grade carotid artery stenosis, who are at an increased risk for surgical carotid endarterectomy (CEA).
- Trial name
- NCT00497094
- Testing
- carotid artery stenting
- Where
- Austria
- Volunteers
- 148 people
- Sponsor
- Vienna General Hospital
Acute Ischemic Stroke
Xingnaojing for Moderate-to-severe Acute Ischemic Stroke (XMAS)
The main purpose of this trial is to determine whether Xingnaojing, intravenously administered within 24 hours of symptom onset, improves the 3-month outcome in participants with acute ischemic stroke.
- Trial name
- XMAS (NCT02728180)
- Testing
- Xingnaojing injection, Standard care
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Dongzhimen Hospital, Beijing
Atrial Fibrillation, Obesity
Effectiveness And Safety Of Oral Anticoagulants Among Obese Patients With Non-Valvular A-Fib In VA Patients With Medicare
The overall objective of this analysis is to understand patient characteristics, the use of treatment, and clinical outcomes among obese (overweight) and severely obese patients with non-valvular atrial fibrillation (NVAF) who…
- Conditions
- Atrial Fibrillation, Obesity, Anticoagulants
- Trial name
- NCT04681482
- Testing
- Apixaban
- Where
- United States
- Volunteers
- 107,383 people
- Sponsor
- Pfizer
Stroke, Cerebrovascular Accident
AMES Treatment of the Proximal Arm in Chronic Stroke
Subjects will receive 30 treatments with AMES, to the proximal arm which has been affected by a chronic stroke.
- Trial name
- AMES (NCT01934439)
- Testing
- 30 PAAD treatments
- Where
- United States
- Sponsor
- Oregon Health and Science University
Critical Care, Hyperchloremia
Multiple Electrolytes Injection (II) and Normal Saline on Hyperchloremia in Severe Hemorrhagic Stroke
Normal saline (0.9% sodium chloride), a classical crystalloid solution, is widely used to maintain fluid balance, volume resuscitation and dilute drugs during clinical practice.
- Conditions
- Critical Care, Hyperchloremia, Hemorrhagic Stroke
- Trial name
- MERIT (NCT06374823)
- Testing
- Multiple Electrolyte, Normal Saline
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Capital Medical University
Aortic Valve Disease, Myocardial Infarction
Aspirin Versus Aspirin+Clopidogrel as Antithrombotic Treatment Following TAVI
The purpose of this study is to compare aspirin/acetylsalicylic acid+ clopidogrel with aspirin/acetylsalicylic acid alone as antithrombotic treatment following TAVI for the prevention of major ischemic events (MI, ischemic…
- Conditions
- Aortic Valve Disease, Myocardial Infarction, Stroke, Bleeding
- Trial name
- ARTE (NCT02640794)
- Testing
- Clopidogrel, Aspirin
- Where
- 4 sites in Canada, Chile and 1 more
- Volunteers
- 222 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Coronary Artery Disease, Chest Pain
Artificial Intelligence Stress Echo (FINESSE) Project
The goal of this observational study is to learn whether combining stress echocardiography (stress echo) results with routine clinical information can better predict important heart outcomes in adults (18+) with chest pain who…
- Conditions
- Coronary Artery Disease, Chest Pain, Myocardial Ischemia, Angina Pectoris
- Trial name
- FINESSE (NCT07432620)
- Testing
- Dobutamine Stress Echocardiography
- Where
- United Kingdom
- Volunteers
- 2,281 people
- Sponsor
- Milton Keynes University Hospital NHS Foundation Trust
Stroke, Dysphagia
PES to Avoid Extubation Failure in Intubated Stroke Patients at High Risk of Severe Dysphagia
Post-extubation dysphagia (PED) recently became a growing concern as a major risk factor for extubation failure and significant contributor to poor patient outcomes with prevalence rates ranging from 12% to 69%, being highest in…
- Conditions
- Stroke, Dysphagia, Extubation Failure
- Trial name
- NCT04010617
- Testing
- Pharyngeal Electrical Stimulation (PES)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Acute Ischemic Stroke, Stroke, Acute
Xingnaojing for Mild-to-severe Acute Ischemic Stroke
The main purpose of this trial is to determine whether Xingnaojing, intravenously administered within 24 hours of symptom onset, improves the daily living ability of acute ischemic stroke at 90 days.
- Conditions
- Acute Ischemic Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- XMAS-2 (NCT04150835)
- Testing
- Xingnaojing injection, Standard care
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Dongzhimen Hospital, Beijing
Ischemic Stroke, Acute
Analyzing the Pharmacodynamic Substances and the Effects of Xingnaojing for Mild-to-Severe Acute Ischemic Stroke
The main purposes of this trial are to analyze the pharmacodynamic substances and the effects of Xingnaojing for mild-to-severe acute ischemic stroke.
- Trial name
- PUBLISH (NCT05559307)
- Testing
- Xingnaojing injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ying Gao
Stroke Rehabilitation
Effectiveness of Transcranial Magnetic Stimulation in Subacute Stroke Patients With Severe Upper Limb Paresis
There has been A-level evidence for the effectiveness of inhibitory rTMS of the contralesional M1 hand region in stroke patients in the acute stage. However, it has been reported to be ineffective in the chronic stage.
- Trial name
- NCT05505201
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Izmir Katip Celebi University
Stroke, Vascular Severe Brain Injury
Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury
The rehabilitation outcome and recovery, in people after stroke or with vascular severe brain injury(vSBI), are difficult to predict.
- Conditions
- Stroke, Vascular Severe Brain Injury, Rehabilitation
- Trial name
- PRISMA (NCT06871800)
- Testing
- blood withdrawal
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Stroke
Tele-CE in Severe Stroke
The goal of this clinical trial is to determine the effects of home-based cross-education on lower limb neuroplasticity in severe stroke.
- Trial name
- NCT07652970
- Testing
- Tele-CE, Tele-Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Illinois at Chicago
Acute Ischemic Stroke
A Phase 1b Study to Assess the Safety and Tolerability of AB126 Neural Exosomes in Patients With Moderate to Severe Acute Ischemic Stroke
The goal of this clinical trial is to learn if AB126, an investigational treatment made from neural exosomes, is safe and well tolerated when given to adults with moderate to severe acute ischemic stroke (AIS) who have undergone…
- Trial name
- NEXIS (NCT07813130)
- Testing
- AB126 Neural Exosomes Intravenous Injection
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Aruna Bio, Inc.
Stroke.
Enhanced Early Supported Discharge for Stroke in Camden
An Early Supported Discharge (ESD) service for stroke is an evidence based intervention that aims to enable a particular group of patients who have a mild to moderate stroke to be discharged from hospital early and receive the…
- Trial name
- EESD (NCT02053987)
- Testing
- Intensive rehabilitation in the home.
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Camden Clinical Commissioning Group