Clinical trials: Severe Stroke
Cardiac Death, Congestive Heart Failure
Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery
This is an observational study designed to monitor the course of the fraction of reticulated platelets and the correlation thereof to major adverse cardiac and cerebrovascular events after noncardiac surgery.
- Conditions
- Cardiac Death, Congestive Heart Failure, Angina Pectoris, Stroke
- Trial name
- NCT02097602
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Stroke
Dose Escalation Upper Limb Rehabilitation in Stroke
A phase 1, single-ascending dose clinical trial will be conducted. This study will be designed to test increasing doses of multimodal exercise in successive cohorts of six participants (cumulative 3 + 3 design)[22] (Figure 1).
- Trial name
- NCT04973553
- Testing
- upper limb rehabilitation
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Hasselt University
Stroke
Transcranial Galvanic Stimulation After Stroke
Transcranial galvanic stimulation (tDCS) seems to promote motor recovery after stroke by stimulating (anodal) or inhibiting (cathodal) neural circuits in the brain.
- Trial name
- TraGAT (NCT00407667)
- Testing
- transcranial galvanic stimulation
- Where
- 3 sites in Germany, Italy
- Volunteers
- 96 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Sleep-disordered Breathing
Apnea, Stroke and Incident Cardiovascular Events
This prospective cohort study aims to compare the proportion of cardiac or cerebrovascular events after a first stroke, a first transient ischemic attack (TIA) or recurrent TIA, between sleep-disordered breathing (SDB) and…
- Conditions
- Stroke, Sleep-disordered Breathing, Sleep Apnea Syndromes, Sleep Apnea, Obstructive
- Trial name
- ASCENT (NCT04399200)
- Testing
- Treatment according to standard care recommandation
- Where
- France
- Volunteers
- 1,620 people
- Sponsor
- University Hospital, Grenoble
Coronary Artery Disease, Atrial Fibrillation
Rivaroxaban Estimation With Warfarin in Atrial Fibrillation Patients With Coronary Stent Implantation Study (REWRAPS)
Antiplatelet therapy is indispensable for the prevention of stent thrombosis in patients who underwent coronary artery stenting.
- Conditions
- Coronary Artery Disease, Atrial Fibrillation, Stroke, Fetal Blood Loss
- Trial name
- REWRAPS (NCT02024230)
- Testing
- Rivaroxaban or Warfarin
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Fujita Health University
Stroke
Effects of Constraint-induced Therapy for the Scapular Kinematics in Patients With Severe Chronic Hemiparesis
The hemiparesis is one of the most important sequelae of stroke, and generally have greater impairment in the upper limb (UL) contralateral to the brain injury.
- Trial name
- NCT02373436
- Testing
- Constraint Induced Therapy, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal de Sao Carlos
Atrial Fibrillation, Stroke
DOAC in Chinese Patients With Atrial Fibrillation
Direct oral anticoagulants (DOACs) have emerged as safe and efficacious ischemic stroke prophylaxis for non-valvular atrial fibrillation (NVAF).
- Conditions
- Atrial Fibrillation, Stroke, Stroke, Acute, Brain Diseases
- Trial name
- DOAC-REAL (NCT05378035)
- Testing
- Blood Tests
- Where
- Hong Kong
- Volunteers
- 427 people
- Sponsor
- Chinese University of Hong Kong
Elderly, Atrial Fibrillation (AF)
Low Dose Edoxaban in Elderly Patients With AF and a History of Stroke
This prospectively enrolled, pragmatic randomized trial aims to investigate whether very low dose edoxaban regimen (15 mg daily) achieves similar edoxaban concentrations as low dose edoxaban regimen (30 mg daily), while…
- Conditions
- Elderly, Atrial Fibrillation (AF), Ischemic Stroke
- Trial name
- LEAVE-Stroke (NCT06900725)
- Testing
- edoxaban, Edoxaban 30 mg
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Ischemic Stroke, Hemoadsorption
Hemoadsorption for Severe Ischemic Stroke
This is a multicenter, randomized-controlled, open-label, blinded endpoint clinical trial that aims to evaluate the efficacy and safety of hemoadsorption for severe ischemic stroke
- Trial name
- NCT07127484
- Testing
- Hemoadsorption
- Where
- China
- Volunteers
- 116 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Stroke, Upper Extremity Paresis
Mental Practice Protocol With Severe Upper Extremity Hemiparesis
This study aims to examine the acceptability of patients and occupational therapists in following a mental practice protocol and examine the effects of mental practice with individuals with severe upper extremity hemiparesis…
- Trial name
- MentalPractice (NCT05519306)
- Testing
- Mental Practice
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Adventist HealthCare
Stroke Acute
Study on the Optimal Head Position for Patients With Severe Acute Ischemic Stroke
Stroke is the second leading cause of death and the third leading cause of disability worldwide, with an increasing incidence. Reperfusion therapy after cerebral ischemia is one of the most practical and effective treatments for…
- Trial name
- NCT07507097
- Testing
- head position
- Where
- China
- Volunteers
- 1,508 people
- Sponsor
- West China Hospital
Stroke, Chronic Stroke
Optimizing Training in Severe Post-Stroke Walking Impairment
Difficulty walking is common after a stroke. Although physical rehabilitation helps a little with the improvement of walking ability, recovery is usually incomplete.
- Conditions
- Stroke, Chronic Stroke, Walking, Difficulty, Gait, Hemiplegic
- Trial name
- BLT2b (NCT04721860)
- Testing
- Backward Locomotion Treadmill Training (BLTT), Forward Locomotion Treadmill Training (FLTT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Cincinnati
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
The purpose of this study is to measure cardiovascular outcomes with orforglipron compared with placebo in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD).
- Trial name
- NCT07241390
- Testing
- Orforglipron
- Where
- 566 sites in Argentina, Australia and 36 more
- Volunteers
- 7,140 people
- Sponsor
- Eli Lilly and Company
Stroke, Hemiparesis
Efficacy of a Combined Transcranial Direct Current Stimulation and Virtual Reality Intervention
Rehabilitation options for stroke survivors who present severe hemiparesis in chronic stages are limited and may end in compensation techniques that involve the use of the less affected arm to achieve some degree of functional…
- Conditions
- Stroke, Hemiparesis, Chronic Stroke, Upper Limb Injury
- Trial name
- REACT01 (NCT03528018)
- Testing
- REACt system, Physical therapy
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospitales Nisa
Stroke, Stroke, Acute
Impact of COVID-19 Vaccines on Cerebrovascular Health
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may reduce the transmission of and achieve population immunity against the COVID-19 pandemic, which accounted for more than 3.75million…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Dementia
- Trial name
- NCT04992195
- Testing
- Laboratory tests and Montreal Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Severe Periodontitis, Ischemic Stroke
Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke
Cardiovascular disease is the world's leading cause of death. Atherothrombosis is a common cause of ischemic stroke. A strong epidemiological link has been established between periodontitis and the risk of stroke.
- Trial name
- PerioStroke (NCT06484036)
- Testing
- periodontal treatment strategy
- Volunteers
- 157 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Moderate to Severe Acute Ischaemic Stroke, Ischaemic Stroke
A Clinical Study to Investigate the Effect of Oral Neflamapimod on Motor Recovery After Acute Ischaemic Stroke
The purpose of this interventional study is to determine whether neflamapimod can improve residual physical disability and/or cognitive dysfunction after Moderate to Severe Acute Ischaemic Stroke.
- Trial name
- RESTORE (NCT06987643)
- Testing
- Neflamapimod
- Where
- 10 sites in Australia
- Volunteers
- 90 people
- Sponsor
- EIP Pharma Inc
Hemorrhagic Stroke, Eclampsia
Investigation of Genetic Disease Marker Associated With Spontaneous Haemorrhagic Stroke Complicating Severe Pre-eclampsia in Pregnancy
To search for a genetic marker of hemorrhagic stroke complicating severe eclampsia, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with hemorrhagic stroke and normal control…
- Trial name
- NCT05121415
- Testing
- SNP analysis of the DNA
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles