Clinical trials: Severe Trauma Patients
Brain Injuries
Use of Standing Frame and "Innowalk Pro" in Patients With TBI
This study will explore physical and physiological responses to mobilization of patients with acquired brain injuries in subacute phase using a classic standing frame and a standing device with simultaneous passive movement of…
- Trial name
- NCT04452019
- Testing
- Use of standard standing frame, Use of a new device; Innowalk Pro
- Where
- Norway
- Volunteers
- 18 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Radiotherapy
Prospective Registration of mOrbidity and Mortality, individUal radioSensitivity and Radiation Technique (PROUST)
Background: Recently, an increasing international interest has arisen in using morbidity and mortality rates to monitor the quality of hospital cares (1, 2).
- Trial name
- PROUST (NCT04253288)
- Testing
- Morbidity Mortality Review (MMR)
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, Surgery
Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection
During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss.
- Trial name
- SHIELD-pilot (NCT07440121)
- Testing
- restrictive fluid infusion, preload, nitro
- Volunteers
- 90 people
- Sponsor
- Zhihong LU
Early Trauma Induced Coagulopathy, Tic
The Incidence of Early Trauma Induced Coagulopathy and Hyperfibrinolysis in Severely Injured Trauma Patients in the Emergency Room: a Retrospective Cohort Study
The aim of this study is to quantify the incidence of eTIC (defined as an elevated appt) and hyperfibrinolysis (defined as Ly30>7) in early trauma patients.
- Trial name
- eTIC (NCT07186712)
- Where
- Austria
- Volunteers
- 263 people
- Sponsor
- Medical University of Graz
Myocardial Injury
Study of Ticagrelor Versus Aspirin Treatment in Patients With Myocardial Injury Post Major Non-cardiac Surgery
The purpose of this pilot study is to establish the rate of cardiovascular events in patients with elevated troponins levels after major, non-cardiac surgery and to evaluate the efficacy and safety of FDA approved study drug…
- Trial name
- INTREPID (NCT02291419)
- Testing
- ticagrelor, aspirin
- Where
- 24 sites in United States
- Volunteers
- 6 people
- Sponsor
- The Cleveland Clinic
Traumatic Brain Injury
Multiomic Analysis of Serum in Acute Period of Traumatic Brain Injury
The goal of this experimental observation study is to figure out differently expressed biomarkers in serum in traumatic brain injury patients, compared with bone fracture patients. The main questions it aims to answer are: 1.
- Trial name
- MASTER-TBI (NCT05867992)
- Testing
- Type of trauma
- Where
- China
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Trauma, Trauma Injury
Whole Blood in Trauma Patients With Hemorrhagic Shock
This study aims to evaluate among trauma patients with hemorrhagic shock the clinical impact of hemostatic resuscitation between whole blood vs.
- Conditions
- Trauma, Trauma Injury, Trauma, Multiple
- Trial name
- WEBSTER (NCT05634109)
- Testing
- Transfusion of blood products
- Where
- Colombia
- Volunteers
- 220 people
- Sponsor
- Fundacion Clinica Valle del Lili
Acute Pain, Burns
Oliceridine in Patients With Acute Burn Injuries
Pain after acute burn injury is complex with much still not understood. The primary mechanism is believed to be nociceptive, but is interwoven with aspects of somatogenic, neuropathic, and psychogenic pathways.
- Conditions
- Acute Pain, Burns, Adverse Drug Event, Respiratory Depression
- Trial name
- RELIEVE (NCT05465226)
- Testing
- Oliceridine, Historical opioid use
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Tennessee
Burns
Assessment of Mechanisms of Improved Wound Healing
The purpose of this study is to find ways to improve wound healing and decrease the negative effects of trauma from burn injury.
- Trial name
- NCT00673309
- Testing
- Stable Isotope Infusion study, Insulin High Dose, oxandrolone
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Anxiety Disorders, Major Depression
CBT vs RTW Intervention for Patients With Common Subclinical Mental Illness in Primary Care
Background: Common mental illness, such as anxiety disorders and depression, is the main cause for sick leave in Sweden. Cognitive behavior therapy (CBT) has been shown to be effective in alleviating target symptoms of these…
- Conditions
- Anxiety Disorders, Major Depression, Stress Disorders, Primary Insomnia
- Trial name
- NCT01667809
- Testing
- Cognitive behavior therapy, Return to work
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Karolinska Institutet
ARDS (Moderate or Severe), ARDS (Acute Respiratory Distress Syndrome)
A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome
This study is a randomized, blank-controlled, open-label, single-dose, dose-escalation clinical study of rhKGF-2 in patients with ARDS.
- Trial name
- NCT07558538
- Testing
- Recombinant Human Keratinocyte Growth Factor-2 for Inhalation (Lyophilized Powder)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Kidney Injury
Efficacy Study of a Selective Cytopheretic Device (SCD) in Patients With Acute Kidney Injury
The purpose of this protocol is to evaluate the safety of a selective cytopheretic device (SCD) in patients that are on continuous renal replacement therapy (CRRT) for acute kidney injury (AKI).
- Trial name
- NCT01400893
- Testing
- SCD
- Where
- 26 sites in United States
- Volunteers
- 134 people
- Sponsor
- SeaStar Medical
Brain Injuries, Disorder of Consciousness
Verticalization Robotic Exoskeleton DoC
Mobilization, specifically verticalization, has been shown to play a role in enhancing consciousness. Vestibular stimulation has the potential to influence the neural substrate of consciousness, but this modality has not been…
- Trial name
- NCT04833543
- Testing
- Robotic Mobility Device (REX), Tilt Table
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Memorial Hermann Health System
Acquired Brain Injury, Consciousness, Level Altered
Physical Activity on Heart Rate Variability in Patients With Severe Acquired Brain Injury
This study aims to explore autonomic cardiovascular regulation, through measures of heart rate variability (HRV), during different passive and active activities in patients with severe acquired brain injury and a low conscious…
- Trial name
- NCT03328221
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acquired Bleeding Disorder, Trauma
Evaluation of Recombinant Factor VIIa in Patients With Severe Bleeding
This trial is conducted globally. The purpose of the trial is to evaluate that activated recombinant human factor VII (eptacog alfa (activated)) is safe and effective in severely injured trauma patients by assessing mortality and…
- Trial name
- CONTROL (NCT00184548)
- Testing
- eptacog alfa (activated)
- Where
- 14 sites in United States, Brazil and 12 more
- Volunteers
- 554 people
- Sponsor
- Novo Nordisk A/S
Hypothermia
Hypothermia in the Trauma Patient - When do Trauma Patients Get Cold?
The purpose of this study is to analyze changes in core body- and skin temperature during pre-hospital and early in-hospital treatment of multi-traumatized patients.
- Trial name
- NCT01006837
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Second or Third Degree Burns
Acute and Long-Term Outcome Investigations of Fenofibrate on Severely Burned Patients
The purpose of this study is to learn the following: whether long-term treatment (6 months) with fenofibrate will decrease burn related sugar and fat increased in the blood and help prevent muscle loss and improve wound healing.
- Trial name
- NCT01574131
- Testing
- Fenofibrate, Sugar Pill
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Caregiver Distress, Emotional Distress
The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury
The purpose of this research study is to determine whether COMA-F is more efficacious at reducing emotional distress in caregivers of patients with severe acute brain injuries, compared to health education control.
- Conditions
- Caregiver Distress, Emotional Distress, Caregivers, Resilience
- Trial name
- COMA-F (NCT07331324)
- Testing
- Coma Family Program 1, Coma Family Program 2
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna