Clinical trials: Severe Trauma Patients
Burns
Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution and Severe Burn Injury
This study aimed to optimize fluid resuscitation with transpulmonary thermodilution (TPTD)-guided protocol and to lower the mortality rate of the severely burned.
- Trial name
- NCT05420610
- Testing
- Control group: Patients being admitted when The advancement of transpulmonary thermodilution(TPTD) device was unavailable., Study group: TPTD device was implemented for monitoring.
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- Chang Gung Memorial Hospital
Brain Injuries, Traumatic
Application of Early Goal-directed Sedation in Patients With Severe Brain Injury
EGDS management strategy was implemented in ICU patients with severe brain injury, the depth of sedation and GCS score were monitored, and the protective effects of EGDS strategy and standard sedation strategy on the brain of…
- Trial name
- NCT04525482
- Testing
- Early goal-directed sedation programs
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Traumatic Brain Injury
Cerebrospinal Fluid Endostatin/Collagen XVIII Concentrations in Patients With Severe Traumatic Brain Injury
Angiogenesis is an important pathophysiological response to traumatic brain injury (TBI) and modulated by pro- and anti-angiogenic factors.
- Trial name
- NCT01846546
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai 6th People's Hospital
Traumatic Brain Injury
Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury
This study evaluates the efficacy of an infusion of Ronopterin (VAS203) on clinical outcome in patients with moderate and severe traumatic brain injury.
- Trial name
- NOSTRA-III (NCT02794168)
- Testing
- VAS203, Saline
- Where
- 29 sites in Austria, France and 3 more
- Volunteers
- 224 people
- Sponsor
- veriNOS operations GmbH
Perioperative Myocardial Injury
Perioperative Copeptin: Predictive Value and Risk Stratification in Patients Undergoing Major Surgery
Observational cohort study examining the perioperative course of copeptin in patients undergoing elevated-risk surgery.
- Trial name
- NCT02687776
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 517 people
- Sponsor
- University Hospital, Basel, Switzerland
Brain Injuries
Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring
This is a prospective, observational cohort study aimed at constructing a machine learning-based prognostic model for severe brain-injured patients.
- Trial name
- CPM-Brain (NCT07198490)
- Volunteers
- 50 people
- Sponsor
- Xingui Dai
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
ARDS (Acute Respiratory Distress Syndrome), VV ECMO
Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDS
The purpose of this study is to find a better way to protect the lungs of patients with Acute Respiratory Distress Syndrome (ARDS) who are being treated with a mechanical ventilator in addition to an extracorporeal membrane…
- Trial name
- PROTECT-ARDS (NCT07790133)
- Testing
- Mechanical Power Targeted Ventilation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Traumatic Injury
Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( TAP Study )
This is a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, large simple trial to investigate the efficacy and safety of a single intravenous (IV) infusion of BE1116 in subjects who have…
- Trial name
- NCT05568888
- Testing
- BE1116
- Where
- 113 sites in United States, Australia and 1 more
- Volunteers
- 1,366 people
- Sponsor
- CSL Behring
ARDS, Acute Lung Injury
Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO
The acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure, presented in 10% of all intensive care patients and carrying a high mortality rate.
- Conditions
- ARDS, Acute Lung Injury, Extracorporeal Membrane Oxygenation, Respiratory Distress Syndrome
- Trial name
- NCT03764319
- Testing
- Ultra-protective ventilator settings, Standard ventilator settings
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Medical University of Vienna
Disorders of Consciousness, Severe Brain Injury
Effect of Repeated tDCS Sessions on Cognitive Improvement in Patients With Disorders of Consciousness
In this study, researchers will show to caregivers of patients how to use a tDCS device (this device was designed to be easy to use, with fixed parameters and only one button to press to run the stimulation).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients
- Trial name
- rtDCS in DOC (NCT02394691)
- Testing
- transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 37 people
- Sponsor
- University of Liege
Critically Ill Patients, Cardiac Surgery
Impact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) Outcome
Critically ill patients are generally exposed to an increased oxidative stress, which is proportional to the severity of their condition.
- Conditions
- Critically Ill Patients, Cardiac Surgery, Trauma, Subarachnoid Hemorrhage
- Trial name
- Etude-AOX (NCT00515736)
- Testing
- Selenium (Se), Zinc (Zn), Vitamin C, Vitamin B1, Vitamin E
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Vitamin D Deficiency, Major Trauma
Vitamin D for Critically Traumatic Patients
Trauma has been an important global public health issue. Yet it is the sixth cause of death in Taiwan, trauma brings great negative impact to national productivity since it presents specifically as the leading cause of death for…
- Trial name
- NCT05449522
- Testing
- Vitamin D
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Tissue Injury, Major Trauma
Markers of Tissue Injury and Rhabdomyolysis in Patients With Major Trauma
Major trauma is associated with a release of alarmins (DAMPs - damage-associated molecular patterns) from the injured tissues. This process results in the activation of the immune system, which is one of the main mechanisms…
- Conditions
- Tissue Injury, Major Trauma, Rhabdomyolysis
- Trial name
- NCT03986736
- Testing
- Laboratory analysis - upon admission, Laboratory analysis - 24 hours after injury
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Ostrava
Pelvic Joint Instability, Pelvic Pain
Surgical Treatment of Pelvic Joint Instability in Patients With Severe Pelvic Girdle Pain After Pregnancy and Trauma
Pelvic girdle pain (PGP) related to pregnancy is a common reason to sick leave during pregnancy. Low back pain and PGP affects about 50% of women during pregnancy.
- Trial name
- NCT00900601
- Testing
- Arthrodesis to the sacroiliac joint and symphysis
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- Oslo University Hospital
Traumatic Brain Injury
Effect of Oral Enteral Nutrition on Severe Traumatic Brain Injury
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- NCT06304012
- Testing
- Nasogastric tube feeding, Intermittent Oro-esophageal Tube Feeding, Rehabilitation therapy
- Where
- Taiwan
- Volunteers
- 104 people
- Sponsor
- Muhammad
ICU, Trauma Injury
Current Situation and Analysis of ICU Management for Severe Trauma Patients in China
Over the past 10 years, there has not been a consensus on ICU nursing management based on the concept of injury control. Case management for patients with serious trauma continues to be initiated in general services and after…
- Conditions
- ICU, Trauma Injury, ICU Acquired Weakness
- Trial name
- NJJLISTP (NCT04944537)
- Testing
- No Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lulu Gu
Trauma, Trauma Injury
Whole Blood in Trauma Patients With Hemorrhagic Shock
This study aims to evaluate among trauma patients with hemorrhagic shock the clinical impact of hemostatic resuscitation between whole blood vs.
- Conditions
- Trauma, Trauma Injury, Trauma, Multiple
- Trial name
- WEBSTER (NCT05634109)
- Testing
- Transfusion of blood products
- Where
- Colombia
- Volunteers
- 220 people
- Sponsor
- Fundacion Clinica Valle del Lili
Patients in Minimally Conscious State After a Severe Brain Injury (e.g., Anoxia, Traumatic Brain Injury, Stroke)
tDCS in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- tDCS in MCS (NCT02019615)
- Testing
- transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University of Liege
Acute Pain, Burns
Oliceridine in Patients With Acute Burn Injuries
Pain after acute burn injury is complex with much still not understood. The primary mechanism is believed to be nociceptive, but is interwoven with aspects of somatogenic, neuropathic, and psychogenic pathways.
- Conditions
- Acute Pain, Burns, Adverse Drug Event, Respiratory Depression
- Trial name
- RELIEVE (NCT05465226)
- Testing
- Oliceridine, Historical opioid use
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Tennessee