Clinical trials: Severe Trauma Patients
Early Waking, Trauma
Effect of Progressive Early Mobilization in Patients With TBI
traumatic brain injury (TBI) is a major public health concern worldwide. Patients with moderate-severe TBI have high rates of disability at the acute phase and frequently require protracted rehabilitation with prolonged periods…
- Conditions
- Early Waking, Trauma, ICU Acquired Weakness
- Trial name
- NCT04810273
- Testing
- Early progressive mobilization
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- National Taiwan University Hospital
Severe Burns, Fluid Resuscitation
Fluid Resuscitation in Burn Patients
Balanced solutions with low chloride concentration could represent an alternative to high chloride concentration solutions. Such balanced solutions contain other acid as buffers (i.e. acetate and/or gluconate).
- Trial name
- CARE (NCT03118362)
- Testing
- Plasmalyte, Ringer lactate
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-traumatic Osteoarthritis
A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis
With IRB approval and informed consent, patients (n=10) (18-50 years old) with post-traumatic knee OA and requiring a tibial plateau and meniscus arthroplasty plus a femoral condyle arthroplasty will be enrolled in the study.
- Trial name
- NCT03257371
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James Stannard
Patients With Closed Neer Type 4 Proximal Humerus Fractures
Pectoralis Major Pedicle Bone Graft For 4-Part Proximal Humerus Fractures
The investigators tried to evaluate the results of our patients who underwent plate osteosynthesis with vascularized pectoralis major graft for the treatment of 4-part proximal humerus fractures.
- Trial name
- NCT04995744
- Testing
- Pectoralis Major Pedicle Bone Graft
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Patients in Minimally Conscious State After a Severe Brain Injury (e.g., Anoxia, Traumatic Brain Injury, Stroke)
tDCS in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- tDCS in MCS (NCT02019615)
- Testing
- transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University of Liege
Sepsis
Preclinical Detection of Sepsis Early in Hospitalized Patients Following Surgery, Injury or Severe Illness
This clinical study is to evaluate a novel biomarker - CNA Rapid Sepsis Dx - to predict the development of sepsis in patients admitted to the hospital with non-sepsis conditions.
- Trial name
- Pre-SEPSIS (NCT04189549)
- Testing
- CNA Rapid Sepsis Dx
- Where
- 5 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Robert Ehrman
Liver Injury
Non-Operative Management of High Grade Blunt Hepatic Injury: Clinical Complications and the Role of Collateral Damage
Little is known about the role of collateral damage in patients with high grade liver injuries (LI). This retrospective single centre study investigates the safety of the non-operative management of patients with high grade blunt…
- Trial name
- NOMLI (NCT00694499)
- Where
- Switzerland
- Volunteers
- 183 people
- Sponsor
- University of Bern
Severe Burn, Enternal Nutrition
A Study on Nutrition Support in Adult Patients With Severe Burns
To delineate nutritional support in adults patients with severe burns to investigate associations between nutritional practice and clinical outcomes.
- Trial name
- NCT03379116
- Testing
- enteral nutrition and parenteral nutrition
- Volunteers
- 100 people
- Sponsor
- Southeast University, China
Brain Injury, Tracheostomy
Efficacy of an Early Rehabilitation on Decannulation Time of Patients With Severe Acquired Brain Injury
All the patients hospitalized in the neuro-rehabilitation after a severe acquired brain injury carrying a tracheal cannula will be retrospectively analyzed.
- Conditions
- Brain Injury, Tracheostomy, Neurological Rehabilitation
- Trial name
- NCT02990871
- Testing
- early neurological rehabilitation, no-early neurological rehabilitation
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Acute Kidney Injury, Mesenchymal Stem Cells
Clinical Trial of Mesenchymal Stem Cells in the Treatment of Severe Acute Kidney Injury
Acute kidney injury(AKI) is a common, severe emergency case in clinics,especially severe AKI ,which is associated with higher morbidity and mortality.
- Trial name
- NCT04194671
- Testing
- Mesenchymal stem cells, Saline
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
ARDS (Acute Respiratory Distress Syndrome)
Comparative Study Between Airway Pressure Release Ventilation and Pressure Regulated Volume Control (PRVC) in Protective Lung Strategy as a Recruitment Maneuver for Severe ARDS Mechanically Ventilated Patients Using Lung Ultrasound Score
The aim of this study is to elaborate on the effectiveness of recruitment maneuver by airway pressure release ventilation (APRV) as an open lung ventilatory strategy in comparison with PRVC mode in lung protective strategy…
- Trial name
- NCT07231107
- Testing
- Lung ultrasound
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Major Trauma
Calcium Levels in Major Trauma
To assess and treat The calcium level abnormalities in major trauma pre and post receiving blood transfusions .
- Trial name
- NCT06103292
- Testing
- ionized calcium levels
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hossam Abdel Rahman Ahmed Ismail
Traumatic Brain Injury
A Pharmacokinetic Analysis of Levetiracetam Prophylaxis in Critically Ill Patients With Severe Traumatic Brain Injury
This study aims is to describe the pharmacokinetic properties of levetiracetam through measurement of serum concentrations in critically ill, severe traumatic brain injury patients.
- Trial name
- NCT04836481
- Testing
- Serum Sample Collection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Study of Hemostatic Profile in Traumatic Patients
Global Hemostasis Monitoring by Using Sonoclot Signature in Traumatic Patients
1. Analyzing the effects of severe trauma using sonoclot analyzer (which depicts the entire hemostatic pathway) ,subsequently describing the convenient therapy . 2.
- Trial name
- NCT04100395
- Testing
- sonoclot
- Volunteers
- 40 people
- Sponsor
- Assiut University
Burns
The RE-ENERGIZE Study: RandomizEd Trial of ENtERal Glutamine to minimIZE Thermal Injury
The purpose of this study is to test the following hypotheses: 1. Enteral glutamine administration decreases in-hospital mortality in adult patients with severe thermal burn injuries. 2.
- Trial name
- RE-ENERGIZE (NCT00985205)
- Testing
- Enteral Glutamine
- Where
- 53 sites in United States, Austria and 12 more
- Volunteers
- 1,201 people
- Sponsor
- Daren K. Heyland
Traumatic Brain Injury
In-Field Detection of Intracranial Pressure
This is a research study to develop a noninvasive test using ultrasound to determine when urgent, life-saving treatment is needed for those with severe traumatic brain injuries.
- Trial name
- NCT04515212
- Testing
- Optic Nerve Ultrasounds
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Duke University
Amputation, Lower Limb
Virtual Reality in the Rehabilitation in Patients With Lower Limb Amputation.
The goal of this clinical trial is to test the impact of virtual reality on rehabilitation for the patients after a major amputation.
- Conditions
- Amputation, Lower Limb, Rehabilitation, Activities of Daily Living
- Trial name
- NCT05773560
- Testing
- virtual reality rehabilitation
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Erlangen
Burns
Organ Protective Effect of Cetirizine In Patients With Severe Burns
This prospective clinical trial aims to investigate the organ protective effects of cetirizine in patients with severe burns.
- Trial name
- NCT06126991
- Testing
- Cetirizine, Midazolam and Fentanyl
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Ruijin Hospital
Gastric Cancer, Surgical Wound Infection
Fatigue and QoL Among Gastric Cancer Patients Undergoing Abdominal Surgery
Background: Cancer-related fatigue (CRF), one of the indicators of QoL, is one of the most common side effects of cancer and its treatment.
- Conditions
- Gastric Cancer, Surgical Wound Infection, Fatigue, Quality of Life
- Trial name
- NCT03766945
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Post-Traumatic Stress Disorder, Depression
Group Intervention for Interpersonal Trauma
This study will assess the acceptability and effectiveness of a six-session, modular, repeating group for low-income women who have symptoms of depression and/or post-traumatic stress disorder following interpersonal trauma…
- Trial name
- NCT00348036
- Testing
- Group Intervention for Interpersonal Trauma, Information only
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Georgetown University