Clinical trials: Severe Trauma Patients, open to volunteers
Trauma Injury
Retrospective Assessment of Referral of a Major Trauma Patient
The aim of this study is to find out whether major trauma patients from the Val d'Oise are referred to the appropriate trauma centre for their care and to assess the quality of triage within the Val d'Oise department.
- Trial name
- SAMU-TRAUMAS (NCT06551350)
- Testing
- Data Collection
- Where
- France
- Volunteers
- 461 people
- Sponsor
- Hôpital NOVO
Brain Injury, Cognitive Impairment
Somatic and Ear Acupuncture for Dysphagia Rehabilitation and Decannulation After Severe Acquired Brain Injuries
The goal of this interventional, randomized, controlled, double-blind pilot study is to assess the superiority of Acupuncture and Auriculotherapy, in addition to conventional speech therapy rehabilitation, for the treatment of…
- Conditions
- Brain Injury, Cognitive Impairment, Deglutition Disorder
- Trial name
- REDACT (NCT06888219)
- Testing
- Acupuncture and Auricolotherapy, Conventional logopedic rehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Radiation Necrosis, High Grade Glioma (III or IV)
Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases
Cerebral radiation necrosis (CRN) is a severe complication of high-dose radiation for brain metastases (BM) or glioma, which can potentially cause significant neurologic symptoms leading to serious morbidity and impaired quality…
- Conditions
- Radiation Necrosis, High Grade Glioma (III or IV), Brain Metastasases, Radiation Toxicity
- Trial name
- BRAINS (NCT06888817)
- Testing
- Bevacizumab, Dexamethasone
- Where
- 6 sites in Netherlands
- Volunteers
- 408 people
- Sponsor
- The Netherlands Cancer Institute
Brain Injuries
Modeling Outcome in Patients With Acquired Brain Injuries
Acquired brain injury (ABI) is the leading cause of death and disability worldwide. The degree of severity varies according to a combination of numerous demographics, etiological, clinical, cognitive, behavioral, psychosocial and…
- Trial name
- MOF-ABI (NCT06162091)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Oral Mucositis, Quality of Life
Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs.
The use of a novel topical mucosa composition (XCM-OM118) comprising 2-(trimethylazaniumyl) acetate; (2R,3R,4S)-pentane-1,2,3,4,5-pentol; Hexadecanoic acid; (9Z, 12Z)-octadeca-9,12-dienoic acid; octadecanoic acid…
- Conditions
- Oral Mucositis, Quality of Life, Mucositis, Pain
- Trial name
- STOPOMP (NCT05635929)
- Testing
- XCM-OM118 Composition comprising olive oil, betaine and xylitol
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Mucosa Innovations, S.L.
Traumatic Brain Injury
Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients
Intensive care management of patient with severe traumatic brain injury (TBI) includes deep and prolonged sedation with intravenous hypnotics (propofol, midazolam, ketamine) in combination with opioids to prevent and/or treat…
- Trial name
- IsoSAFE (NCT06311604)
- Testing
- Isoflurane
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Anesthesia, Surgery
Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection
During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss.
- Trial name
- SHIELD-pilot (NCT07440121)
- Testing
- restrictive fluid infusion, preload, nitro
- Volunteers
- 90 people
- Sponsor
- Zhihong LU
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Severe Trauma Patient, Venous Thromboembolism
Intermediate Versus Standard Dose Enoxaparin to Prevent Venous Thromboembolism in Severe Trauma Patients: a Multicenter Double Blind Randomised Controlled Trial
Venous thromboembolism is a frequent issue in severe trauma patients. Guidelines for venous thromboembolism prevention include the use of pharmacological thromboprophylaxis, mainly with low-molecular-weight heparin, and/or…
- Trial name
- HEPTRAUMA (NCT07506473)
- Testing
- Enoxaparin standard dose, Enoxaparin intermediate dose
- Where
- 17 sites in France
- Volunteers
- 540 people
- Sponsor
- University Hospital, Grenoble
Traumatic Brain Injury, Severe Traumatic Brain Injury
Vagus Nerve Stimulation in Patients in Comatose State
Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation.
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
- Trial name
- NCT07719595
- Testing
- Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sima Mofakham
Traumatic Brain Injury, Severe Traumatic Brain Injury
Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial
The LIMIT-TBI trial is a multicenter, international, randomized, phase II clinical trial designed to evaluate the feasibility and safety of targeting a neutral fluid balance compared to standard care in critically ill adult…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Acute Brain Injury, Neurocritical Care
- Trial name
- LIMIT-TBI (NCT07625995)
- Testing
- Neutral Fluid Balance Strategy
- Where
- 3 sites in Belgium, Italy
- Volunteers
- 88 people
- Sponsor
- Erasme University Hospital
Traumatic Brain Injury
Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions
The purpose of the present study is to study the effect of baricitinib administration on outcome of participants with moderate and severe traumatic intracerebral hemorrhage/contusions.
- Trial name
- NCT06065046
- Testing
- Baricitinib 4 MG, Standard treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Study of Hemostatic Profile in Traumatic Patients
Global Hemostasis Monitoring by Using Sonoclot Signature in Traumatic Patients
1. Analyzing the effects of severe trauma using sonoclot analyzer (which depicts the entire hemostatic pathway) ,subsequently describing the convenient therapy . 2.
- Trial name
- NCT04100395
- Testing
- sonoclot
- Volunteers
- 40 people
- Sponsor
- Assiut University
Myocardial Injury After Noncardiac Surgery (MINS)
SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial
Cardiac complications, particularly myocardial injury after noncardiac surgery (MINS), significantly contribute to 30-day mortality, affecting about 1 in 10 patients after noncardiac surgery.
- Trial name
- NCT06768034
- Testing
- Intervention Group
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Sepsis, Lung Injury
Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery
This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery.
- Trial name
- NCT07601256
- Testing
- Inhalation Anesthesia, intravenous anesthesia
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
ARDS (Acute Respiratory Distress Syndrome)
Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA)
Current clinical guidelines, such as those from the Surviving Sepsis Campaign and ARDSNet, recommend short-term NMBA use for patients with moderate to severe ARDS who exhibit persistent ventilator dyssynchrony or high plateau…
- Trial name
- COBRA (NCT07567768)
- Testing
- Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Polytrauma
Prognostic Value of Capillary Lactatemia in Potentially Severe Polytrauma Patients
Nowadays, the tools available to assess the severity of a polytrauma patient in the pre-hospital setting (vital parameters, shock index, MGAP score, Vittel criteria) have their limitations and are sometimes subjective.
- Trial name
- CLAT (NCT06969404)
- Testing
- capillary blood sampling
- Where
- 3 sites in France
- Volunteers
- 550 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Aortic Dissection Type A
Remote Ischemic Preconditioning for Aute Type A Aortic Dissection Surgery
The goal of this clinical trial is to learn if a technique called remote ischemic preconditioning (RIPC) helps protect organs during emergency surgery for acute type A aortic dissection (ATAAD).
- Trial name
- NCT07383909
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- 16 sites in China
- Volunteers
- 1,312 people
- Sponsor
- Fujian Medical University
Mild Traumatic Brain Injury, Concussion, Mild
Facilitating Access to Specialty Treatment
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- NCT05741411
- Testing
- RPM-assisted specialist access
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Children's Hospital of Philadelphia