Clinical trials: Sevoflurane Anesthesia
Delayed Emergence From Anesthesia
Can Caudal Dexmedetomidine Prevents Sevoflurane Induced Emergence Agitation in Children
Emergence agitation (EA) is common phenomenon in pediatric patients undergoing general anesthesia by inhalation agents. The incidence of EA was reported to range from 18% to 80%.
- Trial name
- NCT02757495
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Suez Canal University
Anesthesia, General, Sevoflurane
Frequency Analysis of Raw EEG During Sevoflurane Anesthesia in Children Younger Than 2 Years Old
The purpose of this study is to analyze raw electroencephalogram in infants younger than 2 years old undergoing general anesthesia using sevoflurane.
- Conditions
- Anesthesia, General, Sevoflurane, Infant
- Trial name
- NCT05148065
- Testing
- BIS, PSi
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Sang-Hwan Ji
Spinal Cord Diseases
Anesthesia Induction in Patients Undergoing Surgery for Cervical Myelopathy
Aim of this trial is to compare propofol-based anaesthesia vs. sevoflurane-based anaesthesia induction in patients with cervical myelopathy receiving oral or nasal fiberoptic intubation.
- Trial name
- Blade runner (NCT01052337)
- Testing
- anaesthetics: sevofluorane
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- University of Roma La Sapienza
One-lung Ventilation (OLV), Low-flow Anesthesia
Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Function During One-Lung Ventilation
This prospective observational study aims to evaluate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing one-lung ventilation (OLV)…
- Conditions
- One-lung Ventilation (OLV), Low-flow Anesthesia, Thoracic Surgery, Respiratory Mechanics
- Trial name
- OLV-LOWSEVO (NCT07085546)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Emergence Agitation
Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation
The goal of this clinical trial is to compare Propofol versus Dexmedetomidine in children undergoing squint surgery. The main question it aims to answer is: Which drug is more effective in preventing the appearance of Emergence…
- Trial name
- NCT06312618
- Testing
- Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oropharyngeal Neoplasms
Isocapnic Hyperventilation - an Alternative Method
Isocapnic hyperventilation (IHV) is a method that shortens time to extubation after inhalation anaesthesia by increasing airway carbon dioxide (CO2) during hyperventilation (HV).
- Trial name
- NCT03074110
- Testing
- Isocapnic hyperventilation
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Sahlgrenska University Hospital
Anesthetic, Sevoflurane
Sevoflurane Concentrations in Children
The sevoflurane concentrations (as well as vital signs, child's date of birth, type of surgery) will be recorded during the first 10 minutes of anesthesia.
- Conditions
- Anesthetic, Sevoflurane, Age
- Trial name
- NCT06510803
- Testing
- The washin of sevoflurane in the GE Ohmeda workstation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- State University of New York at Buffalo
Anesthesia
The Influence of Two Different CO2 Absorbers on Sevoflurane Consumption During Anaesthesia
Traditional sodalime CO2 absorbers are known to not only react with CO2 but also with sevoflurane. Therewith, a potentially harmful compound (compound A) is formed that can be nephrotoxic.
- Trial name
- NCT04271462
- Testing
- Comparing two CO2 absorbers in the ventilator circuit
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Emergence Delirium
Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium
Fifty children undergoing heart catheterization without local anesthesia in the skin will be randomly divided into two groups. Group DM (Dexmedetomidine + Midazolam) and Group KM (Ketamine + Midazolam)
- Trial name
- NCT07427446
- Testing
- Dexmedetomidine and Midazolam, Ketamine and Midazolam
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Emergence Delirium
The PREVENT AGITATION Trial II - Children ≤1 Year
Emergence agitation is a clinical condition in which the child experiences a variety of behavioural disturbances including crying, thrashing, and disorientation during early awakening from anaesthesia.
- Trial name
- NCT05091242
- Testing
- Clonidine, Sodium chloride
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 336 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Bypass Surgery
A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery
To compare two different methods of protecting heart muscle from damage caused by a decreased blood supply. Exposure to the anaesthetic agent sevoflurane can allow the heart muscle to resist longer periods of low blood or oxygen…
- Trial name
- NCT00244283
- Testing
- Sevoflurane, High thoracic epidural analgesia
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Golden Jubilee National Hospital
Intubating Conditions
Propofol-sevoflurane Induction for Pediatric Nasotracheal Intubation.
Pediatric anesthesia differs significantly from adult anesthesia due to physiological differences and increased sensitivity to anesthetic agents.
- Trial name
- NCT07680400
- Testing
- reduced pharmacologic exposure, conventional anesthetic induction
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Bezmialem Vakif University
Cornea, Anesthesia; Reaction
The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients
To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
- Trial name
- NCT03006211
- Testing
- Nitrogen protoxide, Oxygen
- Volunteers
- 40 people
- Sponsor
- Inonu University
Atelectasis
Prevention of Atelectasis, Via High Flow Nasal Cannula to Obtain a PEP, During General Anesthesia in Children
Anesthesia causes respiratory changes and complications, which are the main causes of complications and anesthesia-related deaths.
- Trial name
- PREVAT-PED (NCT03592589)
- Testing
- high flow nasal canula
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Blood Loss, Anesthesia
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures
Sevoflurane is an FDA-approved anesthetic drug commonly used for anesthesia during second trimester abortion procedures. It has a few advantages, including ease of use by the anesthesia provider.
- Trial name
- NCT01048658
- Testing
- Sevoflurane, No Sevoflurane
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Endoscopic Sinus Surgery
PRD-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the utility of Pupillary Dilatation Reflex (PRD) for monitoring pain perception intraoperatively and its influence on intraoperative blood loss, quality of surgical field using…
- Trial name
- FESSPRD (NCT03417206)
- Testing
- Remifentanil, pupillary dilatation reflex
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia
Intracranial Pressure Change, Optic Nerve Diameter
VIMA vs TIVA and ONSD in Laparoscopic Cholecystectomy
This study compared two commonly used general anesthesia techniques in adults undergoing elective laparoscopic gallbladder surgery.
- Trial name
- NCT07786740
- Testing
- Propofol (Astra-Zeneca), Remifentanil, Sevofluorane
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bagcilar Training and Research Hospital
Anesthesia, Hypoventilation
Opioid-sparing Versus Sevoflurane Anesthesia on Early Postoperative Hypoventilation in Laparoscopic Bariatric Surgery
Determine the incidence of early post-operative hypoventilation in post-anesthesia care unit (PACU) in patients undergoing laparoscopic bariatric surgery under opioid-sparing compared with sevoflurane-based anesthesia.
- Conditions
- Anesthesia, Hypoventilation, Opioid Use, Bariatric Surgery
- Trial name
- NCT05962671
- Testing
- Opioid-sparing based anesthesia, Sevoflurane-based anesthesia
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Tanta University
Child, Anesthesia Morbidity
A Study on the Effects of Midazolam on Delirium After Sevoflurane Anesthesia in Pediatric Strabismus Surgery
Sevoflurane with its rapid induction and emergence, hemodynamic stability, and nonirritating airway properties, has acquired widespread acceptance in children.
- Conditions
- Child, Anesthesia Morbidity, Delirium on Emergence
- Trial name
- NCT01680471
- Testing
- Midazolam 0.03mg/kg, Midazolam 0.05mg/kg
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Korea University Anam Hospital
Emergence Delirium, Anesthesia
Effect of Different Drugs on Emergency Delirium in Preschool Age Patient
Emergence delirium (ED) was first described by Eckenhoff and colleagues in the 1960s and is defined in pediatric anesthesia as 'dissociated state of consciousness in which child is irritable, uncompromising, uncooperative…
- Trial name
- NCT07057193
- Testing
- Dexmedetomidine group (D group), Ketamine group (K group), Midazolam group (M group)
- Where
- Egypt
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Zagazig University