One-lung Ventilation (OLV)OLV-LOWSEVONCT07085546
Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Function During One-Lung Ventilation
An observational study of One-lung Ventilation (OLV) and Low-flow Anesthesia, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This prospective observational study aims to evaluate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing one-lung ventilation (OLV) during thoracic surgery. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- One-lung Ventilation (OLV), Low-flow Anesthesia, Thoracic Surgery
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jul 2025to 1 Oct 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients aged 18 to 75 years who are scheduled for elective video-assisted thoracoscopic surgery (VATS) or thoracotomy under general anesthesia with one-lung ventilation at Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital. Eligible participants will have ASA physical status I-III and no acute respiratory failure.
Who may be able to join
- Age between 18 and 75 years American Society of Anesthesiologists (ASA) physical status I-III Scheduled for elective video-assisted thoracoscopic surgery (VATS) or thoracotomy No acute respiratory failure
Who cannot join
- Severe chronic obstructive pulmonary disease (COPD) or restrictive lung disease Body mass index (BMI) greater than 40 kg/m² Cardiac dysfunction with ejection fraction (EF) less than 40% Requirement for emergency thoracic surgery
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
Ankara
About this study
Official title: The Effects of Low-Flow Sevoflurane Anesthesia on Respiratory Mechanics, Gas Exchange, and Postoperative Pulmonary Function During One-Lung Ventilation: A Prospective Observational Study
This prospective observational study aims to evaluate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing one-lung ventilation (OLV) during thoracic surgery. The study will compare patients receiving low-flow sevoflurane anesthesia with those receiving standard-flow anesthesia, focusing on parameters such as lung compliance, arterial oxygen levels (PaO₂), and postoperative oxygen requirements.
Fifty patients scheduled for elective thoracic surgery with OLV will be included. Data will be collected intraoperatively and postoperatively, and standard anesthesia protocols will be followed according to the attending anesthesiologist's preference. The results are expected to provide new insights into the safety and efficacy of low-flow anesthesia protocols in thoracic surgery, potentially guiding future clinical practice to reduce postoperative pulmonary complications.
Read the detailed description
One-lung ventilation (OLV) is a common technique used during thoracic surgery to optimize the surgical field and improve operative conditions. However, OLV is associated with potential complications such as hypoxemia, lung collapse, and inflammatory responses. The choice of anesthesia technique plays a critical role in minimizing these adverse effects.
Low-flow anesthesia (LFA), defined as the administration of inhalational anesthetics with a fresh gas flow rate of 1 L/min or less, offers several advantages, including reduced anesthetic consumption, better humidification of inspired gases, decreased heat loss, and more stable pulmonary gas exchange. Despite these benefits, concerns remain regarding the risk of hypoxemia and the need for careful monitoring of anesthesia depth during LFA.
This prospective, single-center, observational study will investigate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing OLV for elective thoracic surgery. Patients will be allocated to either low-flow or standard-flow anesthesia groups based on routine clinical practice, without randomization. Standard anesthesia and ventilation protocols will be applied according to the attending anesthesiologist's preference.
Primary outcomes include intraoperative lung compliance, arterial oxygenation (PaO₂), and postoperative oxygen requirements. Secondary outcomes include the incidence of atelectasis, anesthetic gas consumption, and hemodynamic parameters. Data will be collected during both intraoperative and postoperative periods. The study aims to enroll 50 patients (25 per group), as determined by power analysis.
The findings of this study are expected to provide comprehensive data on the impact of low-flow sevoflurane anesthesia during OLV, particularly regarding respiratory mechanics and postoperative pulmonary function. These results may contribute to the development of safer and more effective anesthesia protocols for thoracic surgery patients.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Low-Flow Sevoflurane Group | Patients receiving low-flow sevoflurane anesthesia during one-lung ventilation | |
| Standard-Flow Sevoflurane Group | Patients receiving standard-flow sevoflurane anesthesia during one-lung ventilation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Oxygen Requirement
Measured: 24-hour postoperative period
Static Lung Compliance
Static lung compliance (Cstat) will be calculated using the formula: Cstat = VT / (Pplateau - PEEP), where VT is tidal volume, Pplateau is plateau pressure, and PEEP is positive end-expiratory pressure
Measured: Intraoperative period
Arterial Oxygen Pressure (PaO₂)
Arterial oxygen pressure (PaO₂) will be measured from arterial blood gas analysis during one-lung ventilation
Measured: Intraoperative period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jul 2025
- Study start15 Jul 2025
- Primary completion15 Sep 2025
- Study completion1 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for One-lung Ventilation (OLV)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Eda Cennet Caferoğlu, Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07085546
- Sponsor's protocol ID
- 2025-05/56
- Acronym
- OLV-LOWSEVO
- Status last verified
- Sep 2025
- First submitted
- 12 Jul 2025
- Last updated
- 2 Oct 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Low-Flow Sevoflurane Anesthesia on Respiratory Mechanics, Gas Exchange, and Postoperative Pulmonary Function During One-Lung Ventilation: A Prospective Observational Study
- ClinicalTrials.gov ID
- NCT07085546
- Acronym / sponsor ID
- OLV-LOWSEVO / 2025-05/56
- Conditions
- One-lung Ventilation (OLV), Low-flow Anesthesia, Thoracic Surgery, Respiratory Mechanics, Sevoflurane
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalUniversity, hospital or other
- Study start
- 15 Jul 2025 (actual)
- Primary completion
- 15 Sep 2025 (actual)
- Study completion
- 1 Oct 2025 (actual)
- First posted
- 25 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective observational study aims to evaluate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing one-lung ventilation (OLV) during thoracic surgery. The study will compare patients receiving low-flow sevoflurane anesthesia with those receiving standard-flow anesthesia, focusing on parameters such as lung compliance, arterial oxygen levels (PaO₂), and postoperative oxygen requirements.
Fifty patients scheduled for elective thoracic surgery with OLV will be included. Data will be collected intraoperatively and postoperatively, and standard anesthesia protocols will be followed according to the attending anesthesiologist's preference. The results are expected to provide new insights into the safety and efficacy of low-flow anesthesia protocols in thoracic surgery, potentially guiding future clinical practice to reduce postoperative pulmonary complications.
Detailed description
One-lung ventilation (OLV) is a common technique used during thoracic surgery to optimize the surgical field and improve operative conditions. However, OLV is associated with potential complications such as hypoxemia, lung collapse, and inflammatory responses. The choice of anesthesia technique plays a critical role in minimizing these adverse effects.
Low-flow anesthesia (LFA), defined as the administration of inhalational anesthetics with a fresh gas flow rate of 1 L/min or less, offers several advantages, including reduced anesthetic consumption, better humidification of inspired gases, decreased heat loss, and more stable pulmonary gas exchange. Despite these benefits, concerns remain regarding the risk of hypoxemia and the need for careful monitoring of anesthesia depth during LFA.
This prospective, single-center, observational study will investigate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing OLV for elective thoracic surgery. Patients will be allocated to either low-flow or standard-flow anesthesia groups based on routine clinical practice, without randomization. Standard anesthesia and ventilation protocols will be applied according to the attending anesthesiologist's preference.
Primary outcomes include intraoperative lung compliance, arterial oxygenation (PaO₂), and postoperative oxygen requirements. Secondary outcomes include the incidence of atelectasis, anesthetic gas consumption, and hemodynamic parameters. Data will be collected during both intraoperative and postoperative periods. The study aims to enroll 50 patients (25 per group), as determined by power analysis.
The findings of this study are expected to provide comprehensive data on the impact of low-flow sevoflurane anesthesia during OLV, particularly regarding respiratory mechanics and postoperative pulmonary function. These results may contribute to the development of safer and more effective anesthesia protocols for thoracic surgery patients.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Low-Flow Sevoflurane Group | – | –Patients receiving low-flow sevoflurane anesthesia during one-lung ventilation |
| Standard-Flow Sevoflurane Group | – | –Patients receiving standard-flow sevoflurane anesthesia during one-lung ventilation |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients aged 18 to 75 years who are scheduled for elective video-assisted thoracoscopic surgery (VATS) or thoracotomy under general anesthesia with one-lung ventilation at Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital. Eligible participants will have ASA physical status I-III and no acute respiratory failure.
Key inclusion criteria (1 listed)
- Age between 18 and 75 years American Society of Anesthesiologists (ASA) physical status I-III Scheduled for elective video-assisted thoracoscopic surgery (VATS) or thoracotomy No acute respiratory failure
Key exclusion criteria (1 listed)
- Severe chronic obstructive pulmonary disease (COPD) or restrictive lung disease Body mass index (BMI) greater than 40 kg/m² Cardiac dysfunction with ejection fraction (EF) less than 40% Requirement for emergency thoracic surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Postoperative Oxygen Requirement
Time frame: 24-hour postoperative period
Static Lung Compliance
Time frame: Intraoperative period
Static lung compliance (Cstat) will be calculated using the formula: Cstat = VT / (Pplateau - PEEP), where VT is tidal volume, Pplateau is plateau pressure, and PEEP is positive end-expiratory pressure
Arterial Oxygen Pressure (PaO₂)
Time frame: Intraoperative period
Arterial oxygen pressure (PaO₂) will be measured from arterial blood gas analysis during one-lung ventilation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of One-lung Ventilation (OLV) and Low-flow Anesthesia, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Oxygen Requirement (time frame: 24-hour postoperative period). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2025.