Clinical trials: Sex
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Role of Sex Hormones Along the Neuromechanical Axis
Exploring the Modulatory Role of Sex Hormones Along the Neuromechanical Axis in Females
The goal of this project is to test our central hypothesis that changes in sex hormone concentration result in changes to the basic elements of motor control - at multiple levels, from the musculotendinous unit to motor control…
- Trial name
- EMRSHN (NCT03947684)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Meningococcal Meningitis, Serogroup B, Transgender Persons
Investigating Gender and Sex Differences in Immune Responses Through Vaccination of Transgender and Cisgender Persons
Sexual differences are a well-established source of biological variation in immune system functioning, with men often displaying lower adaptive immune responses (e.g.
- Conditions
- Meningococcal Meningitis, Serogroup B, Transgender Persons, Sex Differences in Immune Response, Vaccination
- Trial name
- Vaxxygender (NCT06832514)
- Testing
- Serogroup B meningococal vaccine
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Ghent
Sleep Deprivation, Sex Differences
Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep Curtailment
The goal of this study is to learn whether insufficient sleep affects glucose metabolism differently in healthy men and women.
- Conditions
- Sleep Deprivation, Sex Differences, Glucose Tolerance
- Trial name
- NCT06809023
- Testing
- Sleep restriction
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Female Sex Hormones, Menstrual Cycle
Menstrual Cycle vs. Oral Contraceptives: Effects on Muscle Protein Metabolism After Resistance Exercise
The muscles of the body are constantly breaking down old proteins and building new ones. These two processes, protein breakdown and protein synthesis, together are known as protein turnover.
- Conditions
- Female Sex Hormones, Menstrual Cycle, Oral Contraceptives, Protein Metabolism
- Trial name
- MCOC (NCT07258576)
- Testing
- Protein Beverage, Stable Isotope Tracer [D5]phenylalanine, Stable Isotope Tracer [13C]phenylalanine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cognitive Assessment, Cognition
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults.
- Conditions
- Cognitive Assessment, Cognition, taVNS, Vagus Nerve Stimulation
- Trial name
- NCT07256080
- Testing
- Active taVNS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Adherence, Medication, Risk Reduction
Prevention and Risk: Treatment With a New Emphasis on Relationships
This research examines the efficacy of an individually-delivered intervention tailored for YMSM in relationships. The intervention - termed PARTNER - utilizes a brief (4 session) motivational interviewing format to target…
- Conditions
- Adherence, Medication, Risk Reduction, Drug Use, Sex, Anal
- Trial name
- PARTNER (NCT03396367)
- Testing
- PARTNER, Education Intervention
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Sex Behavior
Evaluation of Asdzáán Be'eená Teen Pregnancy and Substance Use Prevention Program for Native American Youth and Their Caregiver
The objective of this research study is to evaluate a culturally grounded program among American Indian (AI) female adolescents and their female caregivers.
- Trial name
- NCT04863729
- Testing
- Asdzaan Be'eena Program
- Where
- 2 sites in United States
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Germ Cell Tumor, Sex Cord Stromal Tumor
Living After a Rare Cancer of the Ovary: Chronic Fatigue, Quality of Life and Late Effects of Chemotherapy
While they are documented in patients in remission of testicular cancer, the sequelae of chemotherapy and the impact of the disease and its treatments on the living conditions and QoL of women in remission of rare ovarian cancer…
- Conditions
- Germ Cell Tumor, Sex Cord Stromal Tumor, Malignant Non-epithelial Ovarian Tumors
- Trial name
- VIVROVAIRE TR (NCT03418844)
- Testing
- Self-questionnaires of living conditions and quality of life, Cardiac, pulmonary, auditory and biological assessment
- Where
- 19 sites in France
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Centre Francois Baclesse
Sex Work, Pre-Exposure Prophylaxis
Centering Those Engaged in Transactional Sex: A PrEP Innovation for Getting To Zero
Using a participatory implementation science framework, I will test whether an adapted and community empowered group healthcare model, Centering PrEP+, is a feasible and acceptable health system intervention to improve the health…
- Trial name
- C-PrEP+ (NCT05929521)
- Testing
- C-PrEP+
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Human Immunodeficiency Virus, Risk Reduction
Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings
The purpose of this research study is to provide help and support for mental health and human immunodeficiency virus (HIV) risk reduction among Romanian gay and bisexual men.
- Conditions
- Human Immunodeficiency Virus, Risk Reduction, Alcohol Abuse, Depression, Anxiety
- Trial name
- NCT03912753
- Testing
- Comunică, Education Attention Control
- Where
- Romania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alzheimer Disease (AD), Healthy Controls Group - Age and Sex-matched
MIND Diet in Relation to Malnutrition and Depression in AD
The aim of this study was to examine the association between depression, malnutrition, and the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet in Alzheimer's disease…
- Trial name
- NCT07163923
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Abstinence, Sex
EmpowHer is Prevention Curriculum for Youth Ages 10-15 Years.
Alternatives For Girls (AFG's) EmpowHer curriculum is a program for youth who are 10-15 years of age. The curriculum is youth-co-led, and innovative (using online platforms and digitized presentation of material.
- Trial name
- NCT06217809
- Testing
- The intervention curriculum addresses sexual activity, abstinence, and adulthood preparation topics.
- Where
- United States
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Alternatives For Girls
Stigma, Social
Project Orleu: Reducing Intersectional and HIV Stigma Among Health Care Providers and High Risk Women Who Use Drugs in Kazakhstan
Suboptimal linkage to and retention in HIV prevention and care is prevalent among high-risk women who use or inject drugs in both the US and globally, including high HIV incidence contexts like Kazakhstan; addressing HIV and…
- Trial name
- NCT06932796
- Testing
- Health Care Provider Stigma Training and Clinic-Based Messaging Campaign
- Where
- Kazakhstan
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Columbia University
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
A Study to Learn How Elinzanetant Moves Into, Through, and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Kidneys That do Not Work as Well as They Should Compared to Participants Whose Kidneys Work Normally
Researchers are looking for a better way to treat people who have vasomotor symptoms (VMS). The symptoms of VMS are hot flashes. These symptoms can be caused by changes in sex hormone levels.
- Trial name
- NCT05071729
- Testing
- Elinzanetant (BAY3427080)
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Bayer
Alcohol Use, Unspecified, Substance Use
ANCHORS Alcohol & Sexual Health Study: UH3 Project
80 young adult men will complete an initial survey and receive 1 of 2 types of alcohol and sexual health education and information to encourage prevention of alcohol-related problems, HIV and other sexually transmitted infections…
- Conditions
- Alcohol Use, Unspecified, Substance Use, Sex Behavior
- Trial name
- NCT04331704
- Testing
- PrEP acronym (pre-exposure prophylaxis), Initial Web Survey, Interactive Voice Response (IVR) monitoring
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fibromyalgia Syndrome, Healthy Controls Group - Age and Sex-matched
Artificial Intelligence, and E-Health Literacy in Fibromyalgia
This cross-sectional observational study aimed to assess electronic health literacy and artificial intelligence literacy among individuals diagnosed with fibromyalgia syndrome, with particular focus on artificial intelligence…
- Trial name
- NCT07020845
- Testing
- Observation only
- Where
- Turkey (Türkiye)
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Suicide
Implementing Evidence Informed Practices in Schools to Address LGBTQ Adolescent Suicide
Reducing youth suicide in the U.S. is a national public health priority. Sexual and gender minority adolescents are at elevated risk for suicide. Safer school environments, however, can decrease this risk.
- Trial name
- RLAS (NCT02875535)
- Testing
- RLAS
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Sex Trafficking, Sex Crimes
Preventing Commercial Sexual Exploitation of Children
The overall goal of the 5-year project is to conduct both a process and rigorous outcome evaluation of The Set Me Free Projects (SMFP) READY to Stand (RTS) curriculum with an eye toward widespread dissemination to other U.S.
- Conditions
- Sex Trafficking, Sex Crimes, Commercial Sex, Sexual Violence
- Trial name
- Project LIVE (NCT05988398)
- Testing
- READY To Stand Curriculum
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln