Clinical trials: Sex Difference, active
Heart Failure
Heart Failure in Women: Epidemiological and Prognostic Insights
Heart failure (HF) is a leading cause of hospital admission in older adults and women account for more than half of these admissions, yet they remain under-represented in prospective HF cohorts.
- Trial name
- HER-HF (NCT07847983)
- Where
- 24 sites in Spain
- Volunteers
- 430 people
- Sponsor
- Carolina Ortiz Cortes
Heart Failure, Acute Heart Failure
Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?
The goal of this clinical trial is to learn whether a rapid and intensive optimization of heart failure medications in women can improve outcomes after hospitalization for heart failure.
- Conditions
- Heart Failure, Acute Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- PopS-HF (NCT07295522)
- Testing
- Guideline-Directed Medical Therapy (GDMT)
- Where
- 12 sites in Italy
- Volunteers
- 368 people
- Sponsor
- IRCCS Policlinico S. Donato
Musculoskeletal Disorder, Anxiety Disorders
A Multicentre Randomised Controlled Trial of the Norwegian Health in Work Service. The NSAC Efficacy Study
The Norwegian Sickness Absence Clinic (NSAC) is a publicly funded specialist outpatient health service, which is uniquely available for the work force.
- Conditions
- Musculoskeletal Disorder, Anxiety Disorders, Depression, Fatigue
- Trial name
- NSAC (NCT05310695)
- Testing
- NSAC - rapid, NSAC - ordinary, NSAC - active control
- Where
- 5 sites in Norway
- Volunteers
- 2,500 people
- Sponsor
- Nordlandssykehuset HF
Hemodialysis
A Community Health Worker Service to Address Acute Care Utilization Among Young and Middle-Aged Men and Women Receiving Dialysis in High-Poverty Communities
Among adults receiving in-center hemodialysis, young and middle-aged women (aged 18 to 49) have the highest hospitalization rates at 1.8 per person-year.
- Trial name
- NCT07819487
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Male, Female
Sex-difference in Response to Resistance Exercise and Training
Sex-Difference in Response to Resistance Exercise and Training Given the importance of muscular strength for athletic performance as well as for daily activities in the general population-including clinical populations-and the…
- Conditions
- Male, Female, Healthy Adult
- Trial name
- WOMENRESIST S1 (NCT07692815)
- Testing
- Resistance exercise on a leg extension machine, Resistance training on a leg extension machine, Blood samples
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Ebola Virus Disease
REVIVE (Response to the Ebola Virus Vaccine)
This study is a vaccine-related clinical trial which will be conducted by our study team at Kenema Government Hospital (KGH)'s Viral Hemorrhagic Fever Program in collaboration with Tulane University School of Medicine.
- Trial name
- NCT05992480
- Testing
- rVSVDG-ZEBOV-GP Ebola Virus Vaccine (ERVEBO)
- Where
- Sierra Leone
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tulane University
65 Years Older, CHF - Congestive Heart Failure
ChatGPT -Based Intervention for Social Frailty in Older Women With CHF : Gender Differences
The study is planned to be completed over three years and will focus on 500 hospitalized older adults with a diagnosis of CHF. The Biopsychosocial model will be used to conduct this study.
- Conditions
- 65 Years Older, CHF - Congestive Heart Failure, Social Communication
- Trial name
- NCT07091435
- Testing
- ChatGPT, community social
- Volunteers
- 500 people
- Sponsor
- Chang Gung University of Science and Technology
Eumenorrhea, Intrauterine Devices, Medicated
Effect of Different Sex Hormone Profiles for the Response to Physical Training
The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training.
- Conditions
- Eumenorrhea, Intrauterine Devices, Medicated, Hormonal Contraception
- Trial name
- NCT07115849
- Testing
- Physical training
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Alcohol Use Disorder
Guanfacine for Alcohol Use Disorder (AUD)
The investigators assess whether guanfacine extended release (GXR; 3mg/d) compared with placebo (PBO) will attenuate drinking and drinking-related factors in N=200 men and women with Alcohol Use Disorder (AUD) across 12-weeks.
- Trial name
- NCT06629259
- Testing
- Guanfacine Extended Release (XR)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Human Papillomavirus (HPV), HPV Associated Cancers
C2001P-CS3: Testing the Feasibility of Different HPV Screening and Care Strategies for Women Living With HIV
The overall goal of this study is to inform the design and establish feasibility for a future clinical trial to determine the optimal management of women living with HIV (WLWH) with high-risk human papillomavirus (hrHPV) detected…
- Conditions
- Human Papillomavirus (HPV), HPV Associated Cancers, Cervical Cancer, Human Immunodeficiency Virus (HIV)
- Trial name
- NCT07576842
- Testing
- HPV DNA Testing (Abbott Alinity m HPV Assay), Visual Inspection with Acetic Acid, Cervical Histology (Biopsy Procedures)
- Where
- Botswana
- Volunteers
- 750 people
- Sponsor
- University of California, San Diego
Healthy Population
Exploration of Gender Differences in Liver Aging
The liver is an important metabolic organ in the body. It participates in central metabolic activities to maintain systemic homeostasis. It is also one of the most vulnerable organs in the process of individual aging.
- Trial name
- NCT06591897
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Exercise, BDNF
Sex Differences in BDNF Study
A single bout of exercise can improve cognitive abilities like memory and attention. These functions help us navigate through everyday life. However, we do not fully understand how exercise improves cognitive abilities.
- Conditions
- Exercise, BDNF, Sex Differences
- Trial name
- BDNF-SD (NCT07912307)
- Testing
- VO2peak Test
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Asthma (Diagnosis)
Changing Lifestyle to Improve Quality of Life in Spanish Adolescents With Asthma
The goal of this clinical trial is to evaluate if a multicomponent lifestyle intervention can improve health-related quality of life in adolescents with asthma.
- Trial name
- CLiQ-Asthma (NCT07870980)
- Testing
- Lifestyle-change intervention
- Volunteers
- 96 people
- Sponsor
- Universitat Internacional de Catalunya
Violence, Gender-Based, Violence, Domestic
Responsible Engaged and Loving (REAL) Fathers Intervention Evaluation
The goal of this stepped-wedge cluster randomized control trial is to assess whether a Ugandan community-based intervention for young fathers (ages 18-25 years) of children ages 0-3 years impacts fathers' knowledge, attitudes…
- Conditions
- Violence, Gender-Based, Violence, Domestic, Violence, Sexual, Violence, Physical
- Trial name
- NCT06100679
- Testing
- Responsible Engaged and Loving (REAL) Fathers Initiative
- Where
- 4 sites in Uganda
- Volunteers
- 4,728 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Sex Difference, Virtual Care
VR Learning Program for Sexual-and-gender-diversity Care
The study is designed to create a VR learning program for sexual-and-gender-diversity care and compare the short-term and long-term effects on caring behaviors in nursing students.
- Conditions
- Sex Difference, Virtual Care, Nursing Care
- Trial name
- NCT07535216
- Testing
- VR learning program for SGD care
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University Hospital
Cardiac Rehabilitation, Heart Disease
Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation
The SPARC study will measure physical activity and functional fitness during cardiac rehabilitation, right after completion of cardiac rehabilitation, and 6 months later.
- Trial name
- SPARC (NCT07214350)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Inactivity, Physical, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum
The purpose of this study is to determine how anabolic sensitivity, in response to the ingestion of a liquid protein meal, differs across the lifespan, between biological sexes, and with varying physical activity levels.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Growth & Development
- Trial name
- NFRF (NCT06744491)
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
HBV, HBV Coinfection
Changes in Bile Acids and Microbiota in Patients With Hepatitis D Treated With Bulvertide
HDV is an RNA virus that infects only in the presence of HBV, affecting about 13% of HBsAg carriers. In Italy, prevalence ranges from 3.2% to 9.3%.
- Conditions
- HBV, HBV Coinfection, HCV, HIV Infections
- Trial name
- Bio-Delta (NCT07429864)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alcohol Drinking, Sex, Unsafe
Alcohol and "Heat of the Moment" Sexual Decision Making
HIV transmission remains a significant public health concern, especially among men who have sex with men (MSM). Condomless anal intercourse (CAI) continues to be the major route of transmission for MSM.
- Conditions
- Alcohol Drinking, Sex, Unsafe, Hiv
- Trial name
- NCT05729256
- Testing
- Self-Regulation Intervention, Brief Advice and Information
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus