Clinical trials: Sexual Function, open to volunteers
Estrogen, Premenopause
Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women
The purpose of this study is to identify the impact of estradiol (E2) on the associations between (a) responsivity to daily stress or (b) sleep variability with vascular function in midlife premenopausal women.
- Trial name
- V-RISES (NCT06745466)
- Testing
- ganirelix acetate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Bladder Cancer, Cystectomy
Supporting Sexual Recovery in Women With Bladder Cancer
This study looks at how bladder cancer and removing the bladder can affect women's sexual well-being. Bladder cancer can be more serious in women, and treatment like bladder removal can impact how they feel about themselves and…
- Conditions
- Bladder Cancer, Cystectomy, Female Sexual Dysfunction
- Trial name
- SPARC (NCT07091565)
- Testing
- Qualitative interview/Focus group
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King's College London
Breast Neoplasms
Impact of Robotic Versus Endoscopic Surgery on Nipple Nerve Function Following Nipple-Sparing Mastectomy for Breast Cancer
This is a multicenter, prospective, randomized parallel controlled two arm clinical trial, designed to systematically evaluate impact of robotic versus endoscopic surgery on breast nerve function in patients undergoing nipple…
- Trial name
- NCT07850154
- Testing
- Robotic-assisted nipple-sparing mastectomy, Endoscopic-assisted nipple-sparing mastectomy
- Where
- China
- Volunteers
- 374 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno
Spinal Cord Injuries, Bowel Dysfunction
Noninvasive Spinal Cord Stimulation for Early SCI
The investigators are looking to determine the safety and efficacy of non-invasive transcutaneous spinal cord stimulation (TSCS) in promoting recovery of lower urinary tract (LUT), bowel, sexual, and cardiovascular function, as…
- Conditions
- Spinal Cord Injuries, Bowel Dysfunction, Sexual Dysfunction, Autonomic Dysfunction
- Trial name
- NCT06587841
- Testing
- Spinal COrd NEuromodulation™ (SCONE™) for transcutaneous spinal cord stimulation (TSCS)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Sexual Functioning, Transgender Men
Evaluating Sexual Functioning in Trans Men During the Gender Affirmation Process: A Mixed Methods Study
Both sexual experiences and the process of gender transition initiated to reduce gender dysphoria carry cultural characteristics.
- Conditions
- Sexual Functioning, Transgender Men, Gender Affirmation Surgery
- Trial name
- ESFTMGAP (NCT07131267)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)
Polycystic Ovary Syndrome in Type 1 Diabetes
BACKGROUND Functional ovarian hyperandrogenism, including the polycystic ovary syndrome (PCOS), is very prevalent in women with type 1 diabetes (T1D). The pathogenic mechanisms of this association remain unclear.
- Trial name
- NCT07490964
- Testing
- Type 1 diabetes mellitus, Elevated circulating androgen levels, Sex dimorphism
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Radical Prostatectomy, Erectile Dysfunction Following Radical Prostatectomy
EVERiST: Impact of Image Detected Accessory Pudendal Artery on Erection Recovery After Nerve Sparing Prostatectomy
Prostate cancer is the most common cancer amongst men in the United Kingdom, and two common curative treatments are surgery to remove the prostate (radical prostatectomy) or radiotherapy.
- Conditions
- Radical Prostatectomy, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction Due to Arterial Insufficiency, Robotic Radical Prostatectomy
- Trial name
- EVERiST (NCT07597798)
- Testing
- Robotic Radical Prostatectomy, Penile doppler ultrasound
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Urologic Diseases, Male Infertility
Protocol N. 2014 - Observational Study on the Quality of Life of Outpatients
Prospective observational study on the quality of life of patients attending general urology, sexual medicine, reproductive medicine, functional urology, neuro-urology and uro-oncology clinics.The data relating to the clinical…
- Conditions
- Urologic Diseases, Male Infertility, Sexual Medicine
- Trial name
- NCT06193850
- Testing
- Observation during time
- Where
- Italy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Urinary Incontinence, Anal Incontinence
Pelvic Floor Muscle Training During Pregnancy
The project seeks to investigate effectiveness of PFMT during pregnancy.
- Conditions
- Urinary Incontinence, Anal Incontinence, Pelvic Organ Prolapse, Sexual Dysfunction
- Trial name
- NCT07104292
- Testing
- PFMT, Standard care
- Where
- Denmark
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Perineal Trauma, Postpartum Pain
RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or Episiotomy
Perineal tears and episiotomies are common after vaginal birth and may cause persistent pain, impaired wound healing, pain during sexual activity, and concerns about genital appearance.
- Conditions
- Perineal Trauma, Postpartum Pain, Episiotomy, Perineal Laceration
- Trial name
- RELIEVE (NCT07727213)
- Testing
- Autologous Non-Activated Platelet-Rich Plasma, Saline (0.9%, sterile, for infusion)
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Gender Dysphoria
Effects of Cross-sex Hormone Treatment on Cardiac Function, Myocardial and Hepatic Fat Content
Background: Sex hormones are believed to play an important role in the development and progression of cardiovascular disease. However, the gender gap in onset and mortality is not yet completely understood.
- Trial name
- NCT06245681
- Testing
- gender affirming hormone therapy
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Prostate Cancer, Incontinence
Continence, Sexual Function, Fitness and the Health of Men After Surgery for Prostate Cancer
The Continence, Sexual and Metabolic Health (CONTROL 4 LIFE) study will evaluate the recovery of continence, sexual function, and health outcomes in individuals who have undergone surgery for prostate cancer.
- Conditions
- Prostate Cancer, Incontinence, Metabolic Disease
- Trial name
- CONTROL4LIFE (NCT06072911)
- Testing
- Pelvic floor exercise program, General exercise, Physical Activity Counseling
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Alberta
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Leiomyoma (Uterine Fibroids), Adenomyoma of Uterus
The Effect of Uterine Manipulator Use During Abdominal Hysterectomy on Postoperative Sexual Function
This prospective, single-center, randomized controlled trial aims to evaluate the effect of uterine manipulator use during total abdominal hysterectomy on postoperative female sexual function at 3 months, assessed by the Female…
- Conditions
- Leiomyoma (Uterine Fibroids), Adenomyoma of Uterus, Uterine Bleeding
- Trial name
- UMAH (NCT07431788)
- Testing
- Uterine Manipulator, Conventional Abdominal Hysterectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Erkan Gol
Obstetric Anal Sphincter Injury, Anal Incontinence
Pelvic Floor Function After Obstetric Injury to the Anal Sphincter
The goal of this observational study is to learn more about the effect a pregnancy and delivery has on the function of the anal musculature.We will compare women who had a new delivery after suffering a severe tear in the anal…
- Conditions
- Obstetric Anal Sphincter Injury, Anal Incontinence, Urinary Incontinence, Sexual Dysfunction
- Trial name
- PFF (NCT05832268)
- Testing
- Obstetric Anal Sphincter Injury
- Where
- Norway
- Volunteers
- 900 people
- Sponsor
- Oslo University Hospital
Vulvar Lichen Sclerosus
Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus
This is a prospective, randomized study in women of reproductive age with vulvar lichen sclerosus. Participants will be randomly assigned by investigators using a computer-generated sequence to receive either combined dynamic…
- Trial name
- NCT07363733
- Testing
- Dynamic Quadripolar Radiofrequency (DQRF), Topical high-potency corticosteroid
- Where
- Russia
- Volunteers
- 68 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Erection; Incomplete
Pornography Abstinence and Nocturnal Erections in Adult Men
The effects of pornography use on male sexual health remain uncertain, with mixed findings across existing literature and substantial variability at the individual level.
- Trial name
- NCT07618104
- Testing
- Pornography Abstinence
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Adults with Traumatic Penile Severe Defects, Congenital Penile Defects
Pilot Study of PEnile TRAnsplantation - Vascularized Composite Allografts
Penile transplantation (PT) has recently emerged as an option for penile reconstruction and has shown encouraging outcomes at the international level with two ongoing PT program (US, South Africa).
- Conditions
- Adults with Traumatic Penile Severe Defects, Congenital Penile Defects, Micropenis
- Trial name
- PETRA-VCA (NCT06781606)
- Testing
- Penile transplantation
- Where
- 9 sites in France
- Volunteers
- 3 people
- Sponsor
- Hospices Civils de Lyon
Multiple Sclerosis, Healthy Controls Group - Age and Sex-matched
Measurement Properties of the Walking Adaptability Ladder Test and Foot Tap Test in Multiple Sclerosis
Walking and motor control impairments are among the most common manifestations experienced by people with multiple sclerosis (pwMS) and may already be present in individuals with mild disability.
- Trial name
- NCT07505355
- Where
- 4 sites in Belgium, Italy and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasselt University