Clinical trials: Sexually Active, open to volunteers
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Irritable Bowel Syndrome, Erectile Dysfunction
Elliptical Physical Activity and Sexual Dysfunction in Males With Irritable Bowel Syndrome
psychological disturbances resulting from irritable bowel syndrome causes sexual dysfunction in men such as weak erection of penis.
- Trial name
- NCT06783894
- Testing
- exercise (elliptical training)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Postpartum Sexual Dysfunction, Postpartum Depression
POSH-Ex: Physiotherapist-Led Telerehabilitation Exercise Programme for Postpartum Sexual Health
Postpartum women frequently experience impairments in sexual function, pelvic floor dysfunction, fatigue, and depressive symptoms, all of which may adversely affect their quality of life during the postpartum period.
- Conditions
- Postpartum Sexual Dysfunction, Postpartum Depression, Fatigue, Physical Activity
- Trial name
- POSH-Ex (NCT07747285)
- Testing
- POSH-Ex (Postpartum Sexual Health Exercise)
- Where
- Croatia
- Volunteers
- 84 people
- Sponsor
- University Medical Centre Ljubljana
Cardiovascular Diseases, Frailty
Managing Frailty Through Mobilization in Males and Female Inpatients With Cardiovascular Disease
Frailty describes the overall health of a person. Inpatients with cardiovascular problems have a higher risk for frailty - or the sick are more likely to get sicker - causing longer hospital stays, hospital readmission, and…
- Trial name
- NCT06810661
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Sherbrooke
Peyronie's Disease
Assessment of the Value of FAPI and FDG-PET-CT in Diagnosis of Acute Phase Peyronie's Disease
The goal of this clinical trial is to learn if FAPI-PET/CT and/or FDG-PET/CT scan is able to detect active fibroblast tissue and inflammation in patients with acute or chronic phase PD.
- Trial name
- Hippocrates (NCT07903987)
- Testing
- 68Ga-FAPI (gallium-68-labeled fibroblast activation protein inhibitor)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Frailty at Older Adults
Preventing Frailty in Hospital Through Mobilizing
Frailty describes the variability in aging and explains why two people of the same chronological age may look very different. Higher frailty leads to poor quality of life, disability, and death.
- Trial name
- NCT06802289
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Université de Sherbrooke
Metabolic Syndrome
Exercise and Carotid Artery Function in Metabolic Syndrome
The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely…
- Trial name
- NCT07430839
- Testing
- exercise, Diagnostics, Inhaled CO2-mixed air
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection better than a…
- Trial name
- NCT07071623
- Testing
- MK-8527, Emtricitabine/tenofovir disoproxil (FTC/TDF)
- Where
- 30 sites in Kenya, South Africa and 1 more
- Volunteers
- 4,580 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Obese
Dynamo: a Tailored Lifestyle Promotion Intervention Among Pediatric Patients With Cardiometabolic Risk Factors
The Dyn@mo lifestyle intervention (CHU Sainte-Justine, Quebec, Canada) targets children and adolescents aged 6 to 17 years old with cardiometabolic risk factors, such as obesity, hypertension, disorders in glucose regulation or…
- Trial name
- CIRCUIT (NCT01736748)
- Testing
- Sensor based PA intervention, Traditional PA counseling
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Justine's Hospital
HIV Infections
A Phase 2b Study Evaluating VH4011499 Capsid Inhibitor Long-Acting Injectable Plus Cabotegravir in Treatment Naïve Adults (CINERGY)
The purpose of this Phase 2b study is to evaluate the efficacy and therapeutic window of chronically dosed VH4011499 paired with an integrase strand transfer inhibitor (INSTI).
- Trial name
- CINERGY (NCT07816250)
- Testing
- VH4011499, CAB, DTG/3TC
- Volunteers
- 200 people
- Sponsor
- ViiV Healthcare
Endometriosis, Chronic Pelvic Pain
Pelvic Floor Physical Therapy and Exercise for Women With Endometriosis and Chronic Pelvic Pain
Endometriosis is a chronic gynecological condition that can cause persistent pelvic pain, painful menstruation, painful sexual intercourse, and reduced quality of life.
- Trial name
- NCT07733583
- Testing
- Pelvic Floor Physical Therapy, Physical Exercise
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pregnancy Related, Pelvic Floor Disorders
Effects of Reformer Pilates in Pregnant Women
Pregnancy is known as a period associated with important physiological and psychological changes in women's lives. There is moderately sufficient evidence in the literature to recommend supplementing prenatal physical activity…
- Conditions
- Pregnancy Related, Pelvic Floor Disorders, Pain, Back, Pain, Neck
- Trial name
- NCT06777771
- Testing
- Reformer pilates exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Izmir Democracy University
Early-phase Safety and PK Study of a Vaginal Gel
FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL
The goal of this clinical trial is to assess the safety and pharmacokinetics of YASO GEL in healthy adult participants. This is a first-in-human study designed to understand how the gel is absorbed and distributed in plasma and…
- Trial name
- PPCM-01 (NCT07281404)
- Testing
- YASO GEL
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yaso Therapeutics Corporation
Inflammatory Response
Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise
The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise.
- Trial name
- NCT05934708
- Testing
- Eccentric leg extension
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Autophagy, Galectins
Study of Autophagy and the Effects of GALIG Gene Products in HIV-1 Infected Patients Who Are Under Antiretroviral Therapy Since Primary-infection, Chronic Phase, or Never Treated.
Little is known about autophagy during HIV infection. Recently, two different teams reported important dysfunctions of autophagy in HIV-infected patients despite sustained suppressive antiretroviral therapy.
- Conditions
- Autophagy, Galectins, HIV Infections, Highly Active Antiretroviral Therapy
- Trial name
- ATGALIG-HIV (NCT04160455)
- Testing
- expression of a panel
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
HIV (Human Immunodeficiency Virus), Clinical Decision Support System (CDSS)
Evaluating a Clinical Decision Support Tool for Antiretroviral Therapy Optimization
This study is testing software designed to help healthcare providers choose the best HIV treatment combinations for their patients.
- Conditions
- HIV (Human Immunodeficiency Virus), Clinical Decision Support System (CDSS), Antiretroviral Therapy, Highly Active, INDIVIDUALIZED THERAPY
- Trial name
- NCT07219862
- Testing
- smART (Smart Antiretroviral Therapy Assistant), Traditional Prescribing resources
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Keck School of Medicine of USC
HIV
Behavioral Activation and Risk Reduction for Stimulant Use Among Sexually Active Adolescents and Young Adults
The use of behavioral intervention to reduce stimulant use and concurrent HIV sexual transmission risk.
- Trial name
- IMPACT (NCT06444360)
- Testing
- IMPACT, eSOC
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Westat
Tuberculosis
A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB)
The A5414 study will evaluate whether treatment for drug-susceptible pulmonary tuberculosis (TB) can be tailored according to a participant's risk of an unfavorable outcome.
- Trial name
- NCT07595042
- Testing
- Isoniazid, Rifampin, Pyrazinamide
- Where
- 29 sites in Argentina, Australia and 14 more
- Volunteers
- 900 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Prostate Cancer
Comparison of Prostate Cancer-related Quality of Life in Sexually Active Men With Favourable Intermediate-risk Localised Prostate Cancer Treated With Total Prostatectomy or Focal HIFU
The goal of this trial is to assess the impact of focal HIFU therapy on quality of life in patients with favourable intermediate-risk localised prostate cancer.
- Trial name
- QUALIFY (NCT06945172)
- Testing
- Total prostatectomy, Focal HIFU
- Where
- France
- Volunteers
- 102 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)
Researchers are looking for new ways to treat HIV-1 (Human Immunodeficiency Virus Type 1). The usual (standard) treatment for HIV-1 is antiretroviral therapy (ART), which includes taking medicines to lower the amount of HIV-1 in…
- Trial name
- NCT07266831
- Testing
- ISL, ULO, BIC/FTC/TAF
- Where
- 56 sites in United States, Argentina and 7 more
- Volunteers
- 570 people
- Sponsor
- Merck Sharp & Dohme LLC