Clinical trials: Sexually Transmitted Infection (STI)
HIV Infections
A Study of Dideoxyinosine (ddI) in HIV-Infected Children Who Have Not Had Success With Zidovudine or Who Cannot Take Zidovudine
To evaluate the effectiveness, safety, and tolerance of two doses of didanosine (ddI) in the treatment of children with symptomatic HIV disease who have had to discontinue zidovudine (AZT) because of intolerance and/or who have…
- Trial name
- NCT00000963
- Testing
- Didanosine
- Where
- 52 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv, HIV-1-infection
Retrospective Review of DTG/3TC Versus BIC/F/TAF Across a Multi Clinic Infectious Disease Organization in Southeast United States
This real-world retrospective study describes the clinical efficacy of 2DR (DOVATO® (DTG/3TC)) versus 3DR (BIKTARVY® (BIC/F/TAF)) in PWH, including those with at least 2 social determinants of health indicators, across a multi…
- Conditions
- Hiv, HIV-1-infection, HIV Infections
- Trial name
- NCT06393387
- Testing
- DTG/3TC versus BIC/F/TAF
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Midway Specialty Care Center
Pneumonia, Pneumocystis Carinii, HIV Infections
An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies
To determine the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium (TMTX / LCV)) in the treatment of Pneumocystis carinii pneumonia (PCP) in patients who have AIDS, are HIV…
- Trial name
- NCT00000714
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- 21 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Papilloma Virus Infection
Detection of High-Risk HPV in Urine and Cervical Swab Specimen Using HPV Diagnostic Kit (Bio Farma)
This study is a cross-sectional study to evaluate accuracy of high-risk DNA-HPV testing using HPV Diagnostic Kit (Bio Farma) compared to Standard Kit (COBAS® 6800 HPV from Roche Molecular Systems) RT-PCR based in urine and…
- Trial name
- NCT06111911
- Testing
- HPV Diagnostic Kit (Bio Farma)
- Where
- Indonesia
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
HIV Infections
Cabotegravir Plus Rilpivirine Long-acting Regimen in the Swiss HIV Cohort Study:Uptake, Outcome, and Risk Factors for Treatment Failures
This study aims to characterize Swiss HIV Cohort Study participants initiating the CAB+RPV LA regimen, assess adherence to Swiss label indications, and describe treatment outcomes in this large, multicentre, heterogeneous…
- Trial name
- NCT06405464
- Testing
- VOCABRIA 30Mg Tablet, EDURANT 25Mg Tablet, Cabotegravir Injectable Suspension
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- University of Zurich
ART, Hiv
Strengthening Families Living With HIV in Kenya
This study seeks to use a group-based microfinance/internal lending model to develop social capital among people with HIV in Kenya.
- Conditions
- ART, Hiv, Trust, Depression, Anxiety
- Trial name
- NCT04588883
- Testing
- Kuja Pamoja - HIV
- Where
- Kenya
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
HIV Infections
Nelfinavir and M8 Drug-level Monitoring in HIV-1 Infection
The purpose of this study is to assess the impact of prospective drug level monitoring and dose-adjustment of nelfinavir (NFV) on the clinical and virologic outcomes in a group of HIV-infected patients who have achieved virologic…
- Trial name
- NCT00205283
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Alcohol Drinking, Sex, Unsafe
Alcohol and "Heat of the Moment" Sexual Decision Making
HIV transmission remains a significant public health concern, especially among men who have sex with men (MSM). Condomless anal intercourse (CAI) continues to be the major route of transmission for MSM.
- Conditions
- Alcohol Drinking, Sex, Unsafe, Hiv
- Trial name
- NCT05729256
- Testing
- Self-Regulation Intervention, Brief Advice and Information
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
HIV Infections
Doravirine for Obese Persons on Integrase Inhibitors and Tenofovir Alafenamide
The purpose of this study was to determine if people with HIV and obesity taking an antiretroviral treatment regimen containing an integrase strand transfer inhibitor (INSTI) with (tenofovir alafenamide/emtricitabine (TAF/FTC)…
- Trial name
- NCT04636437
- Testing
- Doravirine 100 Mg, Integrase strand transfer inhibitors, Tenofovir alafenamide/emtricitabine
- Where
- 27 sites in United States
- Volunteers
- 147 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
AIDS
A Drug Safety and Dose-exploratory Clinical Study of Azvudine Tablets in Patients Who Have Not Received Anti-HIV Treatment
The primary objective of this trial was to evaluate the safety and preliminary evaluation of Azvudine tablets (FNC) in combination with reverse transcriptase inhibitors therapy in treatment-naive patients with HIV infection.; the…
- Trial name
- FNC (NCT04109183)
- Testing
- The subjects were randomized to the treatment group of 3TC or different doses of FNC. The background drugs were EFV and TDF.
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Henan Genuine Biotech Co., Ltd.
HIV Infections
An mHealth Intervention to Improve HIV Prevention Service Engagement Among People Who Use Drugs
The goal of this single arm pre-post study is to assess the feasibility, acceptability, and preliminary impact of the LOTUS intervention to improve HIV prevention service engagement among people who use drugs.
- Trial name
- LOTUS (NCT06068283)
- Testing
- LOTUS mHealth Intervention Group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hiv, Covid19
HIV/COV in Ukraine-NL
Contradicting preliminary results are available on the impact of COVID-19 in people with HIV (PWH). How achieving goals of the HIV 90-90-90 cascade of care influences the risk of COVID-19 in PWH is unclear.
- Trial name
- NCT04711954
- Where
- 2 sites in Netherlands, Ukraine
- Volunteers
- 1,100 people
- Sponsor
- Erasmus Medical Center
HIV, PrEP
Same-Day PrEP Initiation and Sexual Health for Transgender Women
Transgender women (trans women; assigned male sex at birth but identify as female) are at high risk for HIV infection, and are an important, under-researched population in sub-Saharan Africa.
- Conditions
- HIV, PrEP, Transgender Women, Sexually Transmitted Diseases, Bacterial
- Trial name
- NCT04491422
- Testing
- Integrated Next Steps Counseling with Real-Time Drug Level Feedback
- Where
- Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV Infections
Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV
A single dose of nevirapine (SD NVP) given to an HIV infected pregnant woman followed by a single dose to her infant has been shown to be an effective way of reducing the risk of mother-to-child transmission (MTCT) of HIV.
- Trial name
- P1060 (NCT00307151)
- Testing
- Lamivudine, Lopinavir/ritonavir, Nevirapine
- Where
- 10 sites in India, Malawi and 5 more
- Volunteers
- 452 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Tuberculosis (TB), Tuberculosis Infection, Latent
Screening With Portable X-rays for Rapid Recognition of TB
SPOT-TB (Screening with Portable X-rays for rapid recOgniTion of TB) is a prospective study evaluating a community-based tuberculosis (TB) screening strategy for migrant populations in New York City.
- Conditions
- Tuberculosis (TB), Tuberculosis Infection, Latent, HIV (Human Immunodeficiency Virus)
- Trial name
- SPOT-TB (NCT07737275)
- Testing
- Mobile chest radiography for tuberculosis screening
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Infections
Phase I Safety and Immunogenicity Vaccine Trial Against HIV/AIDS
The development of a vaccine against HIV/AIDS has been primary focused on the structural proteins (Env, Gag) of HIV-1 with the aim of inducing sterilizing immunity by blocking virus entry.
- Trial name
- ISST-001 (NCT00505401)
- Testing
- recombinant HIV-1 Tat protein
- Where
- 4 sites in Italy
- Volunteers
- 27 people
- Sponsor
- Istituto Superiore di Sanità
Human Immunodeficiency Virus (HIV)
Antiretroviral Treatment Strategies in Relation to Adherence, Resistance and Virological Treatment Failure
This project aims to assess different antiretroviral treatment strategies, optimally controlled and conventional, in relation to drug resistance and virological treatment failure.
- Trial name
- DotArv (NCT01433601)
- Testing
- Enhanced Treatment Support (ETS)
- Where
- Vietnam
- Volunteers
- 640 people
- Sponsor
- Karolinska Institutet
HIV Infections
Provision of HIV Self-Test Kit to Emergency Department Patients
The proposed pilot research has three aims: 1) to determine the feasibility and acceptability of provision of HIV self-testing kit in order to increase uptake and engagement of HIV testing among emergency department patients who…
- Trial name
- NCT03021005
- Testing
- HIV Self-testing
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
HIV, AIDS
Smoking Cessation for People Living With HIV/AIDS
In this proposed study with People Living with HIV/AIDS (PLWHA), we will use a stepped care model called a Sequential Multiple Assignment Randomized Trial (SMART) to examine the efficacy of low- and high-intensity smoking…
- Conditions
- HIV, AIDS, Nicotine Dependence
- Trial name
- NCT01965405
- Testing
- Bupropion, Brief Counseling, High-magnitude prize contingency management
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Wayne State University
Toxoplasmosis, Cerebral, HIV Infections
A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine
To evaluate the safety and tolerance of atovaquone (566C80) in AIDS patients with central nervous system (CNS) toxoplasmosis. To evaluate the efficacy of 566C80 in the acute treatment and suppression of CNS toxoplasmosis in AIDS…
- Trial name
- NCT00001994
- Testing
- Atovaquone
- Where
- 22 sites in United States, Canada
- Sponsor
- Glaxo Wellcome
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