Clinical trials: Sham-controlled
Frailty, Thoracic Surgery
A Frailty-specific Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries/Procedures
The purpose of this study is to investigate the effects of the frailty-specific prehabilitation program on functional capacity, frailty, cardiac-specific functional status, serum albumin level, high-sensitivity C-reactive protein…
- Trial name
- NCT07824700
- Testing
- Frailty-specific prehabilitation program
- Where
- Hong Kong
- Volunteers
- 144 people
- Sponsor
- The University of Hong Kong
Tinnitus, Subjective, Hyperacusis
Treatment of Tinnitus With Noninvasive Neuromodulation and Listening Therapy
The goal of this study is to use non-invasive transcranial direct current stimulation (tDCS) combined with active listening therapy to treat tinnitus and hyperacusis and related conditions.
- Conditions
- Tinnitus, Subjective, Hyperacusis, Hearing Disorders
- Trial name
- TDCS (NCT04934371)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arizona
Achilles Tendinopathy
Ultrasound-Monitored Changes in Achilles Tendinopathy After Extracorporeal Shock Wave Therapy
This study is designed as a randomized, placebo-controlled clinical trial in which we monitor the effects of low-energy focused extracorporeal shockwave therapy (ESWT) in patients with Achilles tendinopathy (AT).
- Trial name
- NCT04780919
- Testing
- BTL-6000 FSWT
- Where
- Czechia
- Volunteers
- 18 people
- Sponsor
- University Hospital, Motol
Hot Flashes, Prostate Cancer
Acupuncture Versus Sham Acupuncture or Usual Care for Antiandrogen-Induced Hot fLashes in Prostate Cancer (AVAIL)
Hot flashes are a common and debilitating symptom among prostate cancer patients undergoing androgen deprivation therapy (ADT). Strong evidence from multiple rigorously designed studies indicated that venlafaxine provides partial…
- Conditions
- Hot Flashes, Prostate Cancer, Acupuncture
- Trial name
- AVAIL (NCT05069467)
- Testing
- Acupuncture
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Psychotic Disorders, Mood Disorders
Transcranial Direct Current Stimulation as Treatment for Auditory Hallucinations
The present study aims to examine the efficacy of transcranial direct current stimulation on the severity of auditory hallucinations.
- Conditions
- Psychotic Disorders, Mood Disorders, Personality Disorders, Stress Disorders, Post-Traumatic
- Trial name
- tDCS (NCT01977521)
- Testing
- Eldith DC Stimulator stimulation
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Iris Sommer
Retinitis Pigmentosa (RP)
Prospective, Randomized, Sham-controlled, Dose-finding I/II Trial of Safety and Efficacy of Modified Optogenetic Gene Therapy (ZM-02 Injection)
This is a Phase 1/2, multi-center, randomized, sham-controlled, dose-escalation study evaluating ZM-02 in patients with advanced retinitis pigmentosa (RP).
- Trial name
- PRISM (NCT07282457)
- Testing
- ZM-02 (low dose), ZM-02 (high dose), ZM-02 (selected dose)
- Volunteers
- 21 people
- Sponsor
- Zhongmou Therapeutics
Obesity
StomaphyX Versus Sham for Revisional Surgery in Post-Roux-en-Y Patients to Reduce Regained Weight
The Roux-en-Y gastric bypass (RNYGB) is a weight loss surgery that involves the creation of a small gastric pouch and rearrangement of the small intestine.
- Trial name
- NCT00939055
- Testing
- StomaphyX
- Where
- 2 sites in United States
- Volunteers
- 112 people
- Sponsor
- EndoGastric Solutions
Macular Degeneration
Pegaptanib Sodium on Foveal Thickening in Patients With Exudative Subfoveal Age-Related Macular Degeneration (AMD)
The purpose of this study is to determine if Macugen™ reduces foveal thickness and improves vision in patients with wet AMD.
- Trial name
- NCT00087763
- Testing
- Macugen ™ (pegaptanib sodium injection)
- Volunteers
- 135 people
- Sponsor
- Eyetech Pharmaceuticals
Faecal Incontinence, Faecal Incontinence With Faecal Urgency
Acs-Tens Treatment for Faecal Incontinence: a RCT With Sham-controls
This study assess the effectiveness on AcuTENS on the treatment of faecal incontinence
- Conditions
- Faecal Incontinence, Faecal Incontinence With Faecal Urgency, Neuromodulation, Transcutaneous Electric Nerve Stimulation
- Trial name
- NCT04749316
- Testing
- AcuTENS
- Where
- Hong Kong
- Volunteers
- 53 people
- Sponsor
- Chinese University of Hong Kong
Retinitis Pigmentosa
Safety of a Single, Intravitreal Injection of 6.0M jCell (Famzeretcel) in Retinitis Pigmentosa (RP)
This study evaluates the safety of a single injection of jCell (famzeretcel) comprising 6.0 million (6.0M) retinal progenitor cells over a six-month study period in a cohort of adult subjects with RP.
- Trial name
- NCT06912633
- Testing
- human retinal progenitor cells, Mock injection
- Where
- 12 sites in United States
- Volunteers
- 31 people
- Sponsor
- jCyte, Inc
Nicotine Craving
TNS for Treating Nicotine Craving
Electrical stimulation provides direct modulatory effects on subcortical regions. Indeed, neuroimaging studies show changes in neural activity in specific brain regions such as the amygdala, insula, precentral gyrus, hippocampus…
- Trial name
- TNS-nicotine (NCT02178852)
- Testing
- TRIGEMINAL NERVE STIMULATION (TNS)
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Santa Casa Medical School
Parkinson's Disease, Quality of Life
Study of the Application of Magnetic Fields for the Treatment of Parkinson's Disease
The purpose of this study is to see if a device called the Resonator can help to improve aspects of health and quality of life that are relevant to patients with Parkinson's disease.
- Trial name
- NCT00863226
- Testing
- Resonator Device
- Where
- 6 sites in United States
- Volunteers
- 72 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
Myofacial Pain Syndrome
Extracorporeal Shock-wave Therapy in Myofascial Pain Syndrome
Introduction: Myofascial pain syndrome (MPS) is a syndrome characterized by painful trigger points on palpation located at certain points of common muscles of the musculoskeletal system.
- Trial name
- ESWT (NCT06987721)
- Testing
- Modus ESWT-Focused, Modus ESWT-Radial
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, Knee
Efficacy of High-Intensity Laser Therapy in Early-Stage Symptomatic Knee Osteoarthritis
This randomized, double-blind, sham-controlled clinical trial evaluated the effectiveness of high-intensity laser therapy (HILT) in patients with early-stage symptomatic knee osteoarthritis.
- Trial name
- HILT-ESCOA (NCT07859878)
- Testing
- High-Intensity Laser Therapy (HILT), Standardized Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Ege University
Low Back Pain
Effects of GPR on Non-Specific Chronic Low Back Pain
Introduction: Low back pain affects approximately 18.5% of the Brazilian population in adulthood, significantly impacting the quality of life and generating substantial costs for the health system.
- Trial name
- GPRSHAM (NCT06928597)
- Testing
- Global Postural Reeducation
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Federal University of Bahia
Parkinson Disease, Gait Disorders, Neurologic
Automated Mechanical Peripheral Stimulation to Treat Freezing of Gait in Patients With Parkinson's Disease and STN-DBS
The objective is to investigate whether AMPS (Automated Mechanical Peripheral Stimulation) is effective in reduction of FOG measured via the FOG-AC (Freezing Of Gait Assessment Course) in people with Parkinson Disease and STN-DBS…
- Trial name
- AMBITION (NCT04831879)
- Testing
- GONDOLA AMPS
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Gondola Medical Technologies SA
Ankylosing Spondylitis
A Randomized Trial of Ultrasound-Guided Acupotomy for Ankylosing Spondylitis
This study employs a randomized controlled trial methodology to systematically evaluate the efficacy and safety of a modified acupotomy technique in the treatment of ankylosing spondylitis.
- Trial name
- UGA-AS RCT (NCT07578220)
- Testing
- Ultrasound-guided acupotomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China-Japan Friendship Hospital
Idiopathic Parkinson's Disease
Double-Blind, Multicenter, Sham Surgery Controlled Study of CERE-120 in Subjects With Idiopathic Parkinson's Disease
The purpose of this double blind study is to determine whether CERE-120 (adeno-associated virus serotype 2 [AAV2]-neurturin [NTN]) is effective and safe in the treatment of patients with idiopathic Parkinson's Disease.
- Trial name
- NCT00400634
- Testing
- CERE-120 (Adeno-Associated Virus Serotype 2 [AAV2]-Neurturin [NTN])
- Where
- 9 sites in United States
- Volunteers
- 58 people
- Sponsor
- Sangamo Therapeutics
Refractory Angina, Coronary Artery Disease
Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.
This is a two-part study, comprised of an initial open-label run-in phase (Part 1) in a subset of 3 subjects to provide first data regarding safety, and feasibility of the percutaneous endovascular catheter-facilitated…
- Trial name
- EXACT2 (NCT07048808)
- Testing
- XC001
- Where
- 14 sites in United States
- Volunteers
- 106 people
- Sponsor
- XyloCor Therapeutics, Inc.
Post Operative Pain, Knee Osteoarthritis
Cryoneurolysis Prior to Total Knee Arthroplasty
Knee osteoarthritis is a major issue worldwide with limited treatment options. Many patients receive knee joint replacement surgery which is considered effective and safe.
- Conditions
- Post Operative Pain, Knee Osteoarthritis, Opioid-Related Disorders
- Trial name
- NCT05840276
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
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