Clinical trials: Sham-controlled
Obesity & Overweight
Transcutaneous Auricular Vagus Nerve Stimulation for Poor Weight-Loss Response to Lifestyle Intervention
This single-center, randomized, single-blind, sham-controlled pilot study aims to evaluate the adjunctive effect of transcutaneous auricular vagus nerve stimulation (taVNS) in overweight/obese patients who show a poor weight loss…
- Trial name
- NCT07630597
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
PostTraumatic Stress Disorder
Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Effectiveness
This is a multisite, randomized, blinded, sham-procedure-controlled study to evaluate the efficacy of right-sided stellate ganglion block (SGB) on the acute symptomatology of Post traumatic Stress Disorder (PTSD), evaluated by…
- Trial name
- NCT03077919
- Testing
- Ropivacaine
- Where
- 3 sites in United States, Germany
- Volunteers
- 113 people
- Sponsor
- RTI International
Fatigue, Stroke
Transcranial Direct Current Stimulation in Post-stroke Fatigue
This is a double-blind, sham-controlled, anodal tDCS study to understand the effect of increasing motor cortex excitability on post-stroke fatigue.
- Trial name
- TIPS (NCT04634864)
- Testing
- Anodal tDCS
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- University College, London
Lichen Sclerosus
MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT03665584
- Testing
- FxCO2 Laser
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Center for Vulvovaginal Disorders
Vagus Nerve Stimulations, Spirometry
Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial
This study will examine the short-term effects of transcutaneous auricular vagus nerve stimulation (a non-invasive electrical stimulation delivered through the outer ear) on lung function measured by spirometry in healthy adults.
- Conditions
- Vagus Nerve Stimulations, Spirometry, Autonomic Nervous System (ANS) Functioning and Mood State, Blood Pressure Monitoring
- Trial name
- taVNS-SPIRO (NCT07482930)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Keratoconus
Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
- Trial name
- Apricity-A (NCT06100939)
- Testing
- Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment
- Where
- 13 sites in United States
- Volunteers
- 396 people
- Sponsor
- Epion Therapeutics
Osteoarthritis of Knee
RCT on the Performance and Safety of LightForce® Therapy Lasers on Knee Osteoarthritis Pain Reduction (SPARK)
DJO UK Ltd (ENOVIS) is conducting this study to assess the effectiveness of LightForce® Therapy Lasers on pain reduction in subjects with unilateral or bilateral knee osteoarthritis.
- Trial name
- SPARK (NCT06654739)
- Testing
- Laser therapy + physiotherapy/exercise protocol
- Where
- 7 sites in France, Italy and 1 more
- Volunteers
- 64 people
- Sponsor
- DJO UK Ltd
Alzheimer Disease, Cognitive Impairment
Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015)
This is an open-label extension for a multicenter, randomized, double-blind, sham-controlled, adaptive design pivotal study. Participants who complete the Hope Study (CA-0011) will be eligible to consent for screening to enroll…
- Conditions
- Alzheimer Disease, Cognitive Impairment, Mild Cognitive Impairment, Dementia, Mild
- Trial name
- NCT06245031
- Testing
- Sensory Stimulation System (GS120) - Active
- Where
- 53 sites in United States
- Volunteers
- 402 people
- Sponsor
- Cognito Therapeutics, Inc.
Muscle Spasticity, Stroke
Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity
This is a multi-center, randomized, double-blind (patient and evaluator), sham-controlled study to be conducted in stroke patients with upper-extremity spasticity.
- Trial name
- RECOVER (NCT04742257)
- Testing
- MyoRegulator® device
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- PathMaker Neurosystems Inc.
Somatic Symptom Disorder
Use Repetitive Transcranial Magnetic Stimulation to Treat Somatic Symptom Disorder
This is a randomized double-blind sham-controlled crossover study; the interventions are high-frequency rTMS stimulation on left DLPFC and sham control. The study population is the patient with somatic symptom disorder.
- Trial name
- NCT05161819
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Depression
A Randomized Sham-Controlled Study of H-Coil Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Late-Life Depression
The purpose of the study is to explore the efficacy and safety of H-Coil rTMS in comparison to a sham H-Coil rTMS in older patients with treatment-resistant major depressive disorder.Subjects will be randomized to receive H1-Coil…
- Trial name
- NCT01760681
- Testing
- H- Coil DTMS
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Shalvata Mental Health Center
Down Syndrome
tDCS for Catatonic Depression in Down Syndrome: A Pilot Study
This study evaluates the efficacy of transcranial direct current stimulation (tDCS) for depression with catatonia in individuals with Down syndrome (DS).
- Trial name
- TOTORO (NCT06866925)
- Testing
- Transcranial stimulation
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Hôpital le Vinatier
Androgenetic Alopecia
Sham LaserCap vs. LaserCap SD vs. LaserCap HD+
Androgenetic alopecia (AGA) is a prevalent disease, occurring in 80% of Caucasian men and 50% of Caucasian women by age 701. Treatments for AGA are limited, and presently the only FDA-approved medications for AGA are topical…
- Trial name
- NCT05365360
- Testing
- LaserCap SD, LaserCap HD+
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Multiple Myeloma
To Compare Conservative Management Vs. Balloon Kyphoplasty in the Treatment of VCFs in Patients With Multiple Myeloma
The purpose of this study is to determine whether surgical treatment, balloon kyphoplasty is more effective compared to conservative treatment alone (sham procedure) when assessing clinical, translational, radiological \& patient…
- Trial name
- MELODY (NCT02732925)
- Testing
- Arm 2 Balloon Kyphoplasty, Conservative Management
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Royal National Orthopaedic Hospital NHS Trust
Central Retinal Artery Occlusion
A Study of the Efficacy and Safety of KUS121 in Participants With Acute Non-Arteritic Central Retinal Artery Occlusion (CRAO)
Central retinal artery occlusion (CRAO) is an ophthalmologic emergency which leads to severe and permanent vision loss. There is no evidence-based therapy for CRAO.
- Trial name
- GION (NCT06178055)
- Testing
- KUS121 high dose, KUS121 low dose
- Where
- 11 sites in United States
- Volunteers
- 17 people
- Sponsor
- Kyoto Drug Discovery and Development Co., Ltd.
Neovascular (Wet) Age-related Macular Degeneration (AMD)
Stereotactic Radiotherapy for Wet AMD (STAR)
This study investigates the use of radiation to treat wet age-related macular degeneration (AMD). The radiation is delivered using a robotically controlled device that projects overlapping beams of radiation onto the macula, the…
- Trial name
- STAR (NCT02243878)
- Testing
- 0.5 mg ranibizumab
- Where
- 30 sites in United Kingdom
- Volunteers
- 411 people
- Sponsor
- King's College Hospital NHS Trust
Shoulder Pain, Shoulder Impingement Syndrome
Performance and Safety of LightForce® Therapy Lasers on Shoulder Soft Tissue Inflammation Pain Reduction
DJO UK Ltd (ENOVIS) is conducting this study to assess the effectiveness of LightForce® Therapy Lasers on pain reduction in shoulder soft tissue inflammation.
- Conditions
- Shoulder Pain, Shoulder Impingement Syndrome, Rotator Cuff Tendinitis
- Trial name
- SHINE (NCT06759935)
- Testing
- Laser therapy, physiotherapy/exercise protocol
- Where
- 10 sites in France, Italy and 1 more
- Volunteers
- 104 people
- Sponsor
- DJO UK Ltd
Hypertension, Vascular Diseases
DENEX Renal Denervation in Patients With Hypertension on no Antihypertensive Medications
The objective of this study is to evaluate the safety and effectiveness of renal denervation using DENEX System in patients with hypertension without antihypertensive medication, compared with the sham group.
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases
- Trial name
- NCT04535050
- Testing
- Renal denervation, Renal angiography
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Kalos Medical
Treatment-Resistant Depression
pBFS Guided High-dose rTMS Therapy for Treatment-Resistant Depression
We aim to evaluate the safety and efficacy of pBFS-guided high-dose rTMS therapy with short inter-session interval for patients with treatment-resistant depression
- Trial name
- NCT05842291
- Testing
- Active rTMS with short inter-session interval, Active rTMS with long inter-session interval
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changping Laboratory
Overweight and/or Obesity, Metabolic Syndrome
iWAIST Trial: ERCG (Endoscopic Radial Compression Gastroplasty) +Optimized Lifestyle Intervention (OLI) vs Sham + OLI for Weight Loss
This randomized, sham-controlled trial evaluates the efficacy and safety of ERCG plus optimized lifestyle intervention compared with sham procedure plus optimized lifestyle intervention in Chinese adults with overweight…
- Conditions
- Overweight and/or Obesity, Metabolic Syndrome, Nonalcoholic Fatty Liver Disease
- Trial name
- iWAIST-RCT (NCT07237750)
- Testing
- Endoscopic Radial Compression Gastroplasty, Optimized Lifestyle Intervention (OLI)
- Where
- 2 sites in China
- Volunteers
- 216 people
- Sponsor
- Liu Yan