Clinical trials: Shock, Surgical
Spinal Anesthesia, Pregnancy
Preoperative Shock Indexes and Post-Spinal Hypotension in Cesarean Surgery
This prospective observational study aims to evaluate the predictive performance of preoperative Shock Index (SI) and Modified Shock Index (MSI) for hypotension following spinal anesthesia in elective cesarean surgery.
- Conditions
- Spinal Anesthesia, Pregnancy, Hypotension Postprocedural
- Trial name
- NCT07500519
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Marmara University
Hemorrhagic Shock, Blood Coagulation Disorders
Study Using Plasma for Patients Requiring Emergency Surgery
Information on the management of casualties from the ongoing conflicts in Afghanistan and Iraq has brought in to question the traditional approach to blood transfusion in hemorrhaging patients.
- Conditions
- Hemorrhagic Shock, Blood Coagulation Disorders, Blood Products, Trauma
- Trial name
- SUPPRES (NCT01221389)
- Testing
- Human Plasma
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
High Cut Off Dialysis in Systemic Inflammatory Response Syndrome Patients After Cardiac Surgery
A high cut off dialyzer (septeX) is tested in patients after cardio-thoracic surgery with incidence of "systemic inflammatory response syndrome" (SIRS) and associated increased risk for acute kidney injury (AKI).
- Trial name
- HICOSIRS (NCT01579396)
- Testing
- septeX, standard therapy
- Where
- Germany
- Sponsor
- Vantive Health LLC
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Sepsis, Shock
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness.
- Trial name
- NCT00745888
- Testing
- Chemiluminescence Analyzer
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Systemic Inflammatory Response Syndrome
Safety and Efficacy of Adding Intravenous N-acetyl Cysteine in Colon Surgeries
The use of antioxidant agents in the prevention or decreasing the severity of postoperative systemic inflammatory response syndrome after colonic surgeries adopted nowadays.
- Trial name
- NCT03589495
- Testing
- N Acetyl L Cysteine, dextrose 5%
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Systemic Inflammatory Response Syndrome, Cardiopulmonary Bypass
Study of Albumin to Reduce Inflammation Following Surgery
The purpose of this study is to determine whether albumin administration during cardiac surgery is effective in attenuating the development of inflammation following surgery.
- Trial name
- NCT00773110
- Testing
- 20% Human albumin solution, Gelofusin
- Where
- United Kingdom
- Volunteers
- 232 people
- Sponsor
- Imperial College London
Preventive Medicine, Multi Organ Failure
Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of Multi-Organ Failure on Patients After Open Surgery for a RAAA
A study to assess effectiveness and safety of a drug FP-1201-lyo (Recombinant Human Interferon Beta-1a) in the Prevention of Multi-Organ Failure on patients after Open Surgery for a Ruptured Abdominal Aortic Aneurysm
- Trial name
- INFORAAA (NCT03119701)
- Testing
- Interferon Beta-1A
- Where
- 9 sites in Estonia, Finland and 1 more
- Volunteers
- 40 people
- Sponsor
- Faron Pharmaceuticals Ltd
Sepsis
Incidence of Sepsis After Craniocerebral Operation
To investigate the incidence and outcome of sepsis in critical patients undergoing craniotomy.
- Trial name
- NCT03803813
- Where
- China
- Volunteers
- 907 people
- Sponsor
- Jianfang Zhou
Coronary Heart Disease (CHD), Cardio-pulmonary Bypass
Protective Effect of EECP Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery
Enhanced external counterpulsation (EECP) is a noninvasive, non-pharmacologic intervention proven to increase nitric oxide bioavailability in patients with coronary artery disease.
- Conditions
- Coronary Heart Disease (CHD), Cardio-pulmonary Bypass, Congestive Heart Failure Chronic, Cardiogenic Shock Acute
- Trial name
- PANDA (NCT06728605)
- Testing
- Enhanced External Counterpulsation (EECP)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Necrotizing Soft Tissue Infection, Necrotizing Fasciitis
Biomarkers in Patients With Flesh-eating Bacterial Infections
The purpose of this study is to investigate the immune response in patients with necrotizing soft tissue infections (NSTI). The investigation will focus on inflammatory and vasoactive biomarkers as prognostic markers of severity…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fasciitis, Gas Gangrene, Fournier Gangrene
- Trial name
- BIONEC (NCT02180906)
- Where
- Denmark
- Volunteers
- 169 people
- Sponsor
- Ole Hyldegaard
Thoracic Surgery, Video-Assisted
A Prospective Descriptive Study of the Individualized Capnography of Both Lungs During One-lung Ventilation With Double-lumen Tube
A prospective descriptive study of the use of an individualized capnography to each lung in the context of one-lung ventilation achieved with a double-lumen tube.
- Conditions
- Thoracic Surgery, Video-Assisted, Double-Lumen Tube, Capnography
- Trial name
- EtCO2-DLT (NCT04962581)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Acute Kidney Injury Due to Circulatory Failure (Disorder)
The Effects of Oxiris on Systemic Inflammation and Endothelial dysFunction
CS-AKI occurring in 20% to 70% of cases depending of the type of cardiac surgery. The systemic inflammatory response is often observed and associated with increased risk of AKI.
- Trial name
- EOSIEF (NCT04257006)
- Testing
- oXiris membrane
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders
Effects of Cardiopulmonary Bypass (CPB)-Leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function
To test the hypothesis that leukocyte filtering during cardiopulmonary bypass (CPB) might reduce the inflammatory response and protect the lungs against the acute injury
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Leukocyte Disorders, Complications Due to Coronary Artery Bypass Graft
- Trial name
- PulmFunction (NCT01469676)
- Testing
- Filtering group LG-6, Pall Biomedical Products
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Video-assisted Thoracoscopic Surgery, One-Lung Ventilation
Compared Unidirectional Valve Apparatus and Occluding the Non-ventilated Endobronchial Lumen for Lung Collapse.
With the rapid advancement of thoracoscopic surgery in recent years, surgeons have set higher standards for the quality of non-ventilated lung collapse.
- Trial name
- NCT06210256
- Testing
- unidirectional valve apparatus, occluding the non-ventilated endobronchial lumen
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Sichuan University
Septic Shock, Severe Trauma
REAnimation Low Immune Status Markers
The fact that sepsis disrupts immune system homeostasis by inducing an initial cytokine storm, that participates to occurrence of organ failures and early death, followed by a compensatory anti-inflammatory response leading to…
- Conditions
- Septic Shock, Severe Trauma, Severe Burn, Major Surgery
- Trial name
- REALISM (NCT02638779)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Vasoplegic Shock, Cardiopulmonary Bypass
Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)
The goal of this study is to conduct a prospective trial implementing a modified version of the Emory Protocol for administering ANG II to patients with post cardiac bypass vasoplegia.
- Conditions
- Vasoplegic Shock, Cardiopulmonary Bypass, Vasoplegia
- Trial name
- ANGII_V (NCT07671365)
- Testing
- Angiotensin II (Giapreza®)
- Volunteers
- 329 people
- Sponsor
- Methodist Healthcare System of San Antonio
Cardiogenic Shock, Acute Decompensated Heart Failure
SURPASS Impella 5.5 Study
A multi-center, prospective \& retrospective, observational single-arm study of the clinical outcomes up to one year collected from electronic health records of patients which have undergone standard of care implantation of…
- Trial name
- NCT05100836
- Testing
- Impella 5.5
- Where
- 15 sites in United States
- Volunteers
- 1,017 people
- Sponsor
- Abiomed Inc.
Sepsis, Hip Fractures
The Association Between Preoperative Sepsis and the Mortality After Hip Fracture Surgery
The worldwide occurrence of hip fracture is high with an annual incidence of approximately 100 per 100.000 people. Mortality for patients undergoing hip fracture surgery is high with a 30-day mortality rate varying between 4.5…
- Trial name
- NCT03201679
- Testing
- Repair of hip fracture
- Volunteers
- 1,967 people
- Sponsor
- Bispebjerg Hospital
Systemic Inflammatory Response Syndrome, Inflammation
Effect of TEAS on the Incidence Rate of SIRS in Patients Undergoing Abdominal Surgery
The purpose of this study is to access the effect of Transcutaneous Electrical Acupoint Stimulation(TEAS) on the Incidence rate of Systemic Inflammatory Response Syndrome (SIRS) in patients undergoing radical surgery for gastric…
- Trial name
- NCT02193477
- Testing
- TEAS
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Air Force Military Medical University, China