Clinical trials: Shock, Surgical
Rotator Cuff Tear
Study on the Application of Shock Wave Technique After Rotator Cuff Operation
This study is a prospective cohort study and is a single-center clinical trial. The subjects of this study were patients who underwent rotator cuff repair in the Department of Sports Medicine and the Department of Rehabilitation…
- Trial name
- NCT06563739
- Testing
- Divergent low energy shock wave, Divergent medium and low energy shock wave, Focused low energy shock wave
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Cardiogenic Shock
Awake Axillary Impella 5.5 Placement - A Feasibility Trial
The Abiomed Impella 5.5 is a surgically placed temporary mechanical support device used in patients in cardiogenic shock. The investigators propose using regional anesthesia (3 separate peripheral nerve blocks) to facilitate…
- Trial name
- NCT05782491
- Testing
- Interscalene Block, PECS II Block, Superficial Cervical Plexus Block
- Where
- 2 sites in United States
- Sponsor
- University of Pennsylvania
Systemic Inflammatory Response Syndrome
Can Biomarkers Aid in the Prediction of Postoperative Pain and Circulatory Instability After Major Abdominal Surgery?
Patients undergoing major surgery are exposed to extensive damage of tissues, which induces widespread activation of the inflammatory system, called 'systemic inflammatory response syndrome' (SIRS).This activation of the…
- Trial name
- NCT02563652
- Where
- 2 sites in Italy, Norway
- Volunteers
- 101 people
- Sponsor
- St. Olavs Hospital
Postoperative Complications, Multiple Organ Failure
Dalargin for Prevention of Organ Disfunction in High-Risk Abdominal Surgery
Major abdominal surgeries (e.g., gastrectomy, pancreatectomy, colectomy) carry a high risk of life-threatening postoperative complications, including multiorgan disfunction syndrome (MODS), acute kidney injur (AKI), miocardial…
- Conditions
- Postoperative Complications, Multiple Organ Failure, Abdominal Surgery
- Trial name
- Dal-PROTECT (NCT07404358)
- Testing
- Dalargin, 0.9 % NaCl
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Botkin Hospital
Hemorrhage, Cardiac Surgery
Biological and Clinical Relevance of Quantra Viscoelastic Hemostatic Assay in Hemorrhagic Cardiac Surgery
The goal of this observational study is to assess the correlation between Quantra viscoelastometric assay and laboratory hemostasis biology in a cardiac surgery cohort presenting with acute hemorrhage in the operating room.
- Conditions
- Hemorrhage, Cardiac Surgery, Hemorrhagic Shock
- Trial name
- QASH (NCT07105904)
- Testing
- Viscoelastometric hemostatic assay
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Pitié-Salpêtrière Hospital
Cardiac Surgery Recovery, Inflammation
Jafron Cytokine Adsorber During Pediatric Open-Heart Surgeries
This prospective single-center randomized controlled trial aims at evaluating the safety and feasibility of an hemoadsorption protocol using Jafron HA-60 during cardio-pulmonary bypass in 20 pediatric patients undergoing…
- Conditions
- Cardiac Surgery Recovery, Inflammation, Complex Cardiovascular Surgery With Cardiopulmonary Bypass, Cytokine Storm
- Trial name
- JACKPOT (NCT07393087)
- Testing
- Hemoadsorption
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hypovolemic Shock, Trauma
Impact of Early Goal-directed Fluid Therapy in Hypovolemic Patients Undergoing Emergency Surgery
This study compares the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in trauma patients requiring emergency surgery.
- Conditions
- Hypovolemic Shock, Trauma, Emergency, Surgery
- Trial name
- NCT01653977
- Testing
- CONTROL, OPTIMIZED
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Overactive Bladder, Urinary Incontinence, Urge
Efficacy of Li-SWT on Persistent Storage Symptoms After Transurethral Surgery for BPO
comparing the outcome of low-intensity shock wave therapy (Li-SWT) versus solifenacin on persistent storage symptoms after transurethral surgery for benign prostatic obstruction (BPO)
- Conditions
- Overactive Bladder, Urinary Incontinence, Urge, Urgency-frequency Syndrome, Post Prostatectomy
- Trial name
- NCT04437108
- Testing
- Li-SWT (suprapubic approach), Li-SWT (perineal approach), Li-SWT (combined approach)
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Mansoura University
Systemic Inflammatory Response Syndrome (SIRS)
Systemic Inflammatory Response Syndrome (SIRS) in Patients Undergoing Major Procedures in Oral and Maxillofacial Surgery
Patients undergoing major procedures in oral and maxillofacial surgery more often develop a systemic inflammatory response syndrome (SIRS) in the first days of postoperative critical care therapy than patients with a comparable…
- Trial name
- NCT01921049
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Cologne
Respiratory Failure, Shock
Comparing Post Cardiac Surgery Outcomes in ESRD Patient's With Early Dialysis Versus Standard Care
End-stage renal disease (ESRD) is an important risk factor for coronary and valvular cardiac disease leading to cardiac surgery.
- Conditions
- Respiratory Failure, Shock, Coagulopathy
- Trial name
- NCT04705701
- Testing
- Hemodialysis
- Sponsor
- Northwell Health
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Multiple Organ Failure
Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection
Multiple organ dysfunction syndrome (MODS) after surgical repaired for acute type A aortic dissection (ATAAD) is a life-threatening condition.
- Trial name
- NCT04356300
- Testing
- Exosome of MSC
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Shock, Cardiovascular Diseases
Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery
This study will examine the differences in microcirculatory function and mitochondrial respiration in patients with shock after cardiovascular surgery.
- Conditions
- Shock, Cardiovascular Diseases, Critical Illness
- Trial name
- MicroRESUS (NCT05330676)
- Testing
- coronary artery bypass grafting, valve repair/replacement
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pennsylvania
Critical Illness, Septic Shock
Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study)
This study will test whether giving human albumin to keep the blood albumin level above 3.5 g/dL, in addition to standard care, improves survival in patients with surgical septic shock.
- Trial name
- ALBUS (NCT07212582)
- Testing
- Human Albumin 20% Solution, Standard Care (in control arm)
- Where
- Thailand
- Volunteers
- 304 people
- Sponsor
- Mahidol University
Heart Diseases, Heart Valve Diseases
Acute Kidney Injury After Cardiac Surgery
The study aims to identify the Following: - 1. incidence and mortality of cardiac Surgery associated -AKI based on the new consensus diagnostic systems of KDIGO (Kidney Disease Improving Global Outcomes). 2.
- Conditions
- Heart Diseases, Heart Valve Diseases, Heart Shock, Cardiac Disease
- Trial name
- NCT05079724
- Testing
- Cardiac Surgery
- Volunteers
- 200 people
- Sponsor
- Assiut University
Acute Circulatory Failure During One-lung Ventilation Surgery
Use of Mini-fluid Challenge for Fluid Responsiveness Prediction During One-lung Ventilation
During thoracic surgery, an excessive use of fluid results in pulmonary complications. Dynamic fluid responsiveness predictors are not easily usable during one lung ventilation.
- Trial name
- NCT02858115
- Testing
- Fluid challenge, Trans-oesophageal echography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Shock, Surgical, Shock
Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients
The current standard of catecholamine vasopressor management of perioperative hypotension in kidney transplant patients carries significant risks and falls short in many ways.
- Conditions
- Shock, Surgical, Shock, Hypotension and Shock, Kidney Transplant; Complications
- Trial name
- NCT04529005
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Cardiogenic Shock, Post-cardiac Surgery
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
The use of antibiotic therapy is common in intensive care units and primarily involves beta-lactams. Its optimal implementation is made difficult by the pharmacokinetic changes inherent in critically ill patients.
- Conditions
- Cardiogenic Shock, Post-cardiac Surgery, Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
- Trial name
- KAMELOT (NCT06338345)
- Testing
- Therapeutic drug monitoring of beta-lactam
- Where
- 5 sites in France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Thoracic Surgery, Prehabilitation
Preoperative Inspiratory Muscle Training Effects on the Perioperative Inflammatory Reaction in Cardiac Surgery.
This study evaluates the impact of preoperative high-intensity inspiratory muscle training (IMThi) before cardiac surgery on perioperative inflammatory response.
- Conditions
- Thoracic Surgery, Prehabilitation, Respiratory Therapy
- Trial name
- EMI HiPo (NCT03158402)
- Testing
- Prehabilitation with inspiratory muscle training
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers