Clinical trials: Shock, Surgical
Systemic Inflammatory Response Syndrome, Postoperative Shock
The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery
In this randomized, double-blind, placebo-controlled study, the investigators will assess whether preoperative disruption of the gut microbiota by a course of broad spectrum antibiotics will attenuate the postoperative systemic…
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Shock, Coronary Artery Disease, Extracorporeal Circulation; Complications
- Trial name
- REMEDI (NCT03939273)
- Testing
- Vancomycin Oral, Metronidazole Oral, Ciprofloxacin Pill
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm
Onalespib and CDKI AT7519 in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of onalespib and CDKI AT7519 in treating patients with solid tumors that have spread from the primary site (place where they started) to other places in the body…
- Conditions
- Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Unresectable Solid Neoplasm
- Trial name
- NCT02503709
- Testing
- CDK Inhibitor AT7519, Laboratory Biomarker Analysis, Onalespib
- Where
- 6 sites in United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Heart Disease (CHD)
Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy
This study is dedicated to determination of the long term effectiveness of coronary heart disease (CHD) treatments - cardiac shock wave therapy (CSWT) in comparison with other kinds of medical and surgical treatment.
- Trial name
- CSWTSPB40 (NCT01631409)
- Testing
- Treatment of CHD risk factors, Aspirin, Isosorbide mononitrate, Atenolol, Enalapril., PCA
- Sponsor
- City Hospital No 40, Saint Petersburg, Russia
Circulatory Shock, Non-cardiac Surgery
Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery
The purpose of the present study is to evaluate the effect of vasopressin compared to norepinephrine on the clinical complications of patients with vasospastic shock after noncardiac surgeries.
- Trial name
- VANCSIII (NCT03483753)
- Testing
- Vasopressin, Norepinephrine
- Sponsor
- University of Sao Paulo
Systemic Inflammatory Response Syndrome, Jaundice, Obstructive
Cholinergic Anti-inflammatory Pathway in Prevention & Treatment of the SIRS in Patients With Jaundice After Operation.
RATIONALE:Anticholinesterase drugs and cholinergic M receptor antagonist are applied to patients who have obstructive jaundice after operation.
- Trial name
- NCT02279147
- Testing
- neostigmine methylsulfate，raceanisodamine hydrochloride
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wanqing Gu
Sepsis, Postoperative Complications
Risk Factors Identification of Sepsis and Septic Shock After Major Abdominal Surgery Based on Artificial Intelligence
The goal of this observational study is to identify the risk factors and build the early warning system of sepsis and septic shock after major abdominal surgery based on artificial intelligence.
- Trial name
- NCT06684340
- Testing
- Exposure to major abdominal surgery
- Volunteers
- 22,646 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Artificial Intelligence for Ulinastatin Responder Outcome & Risk Assessment in CPB
This is a multicenter, retrospective, real-world observational study aimed at developing and validating an artificial intelligence-based tool for identifying ulinastatin treatment responders and risk stratification in cardiac…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- AURORA (NCT07583290)
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Efferon LPS Hemoadsorption in Cardiac Surgery Patients
This randomized controlled study aims to evaluate the efficacy and safety of intraoperative and early postoperative hemoadsorption using the Efferon® LPS device in patients undergoing cardiac surgery with cardiopulmonary bypass…
- Trial name
- NCT07532174
- Testing
- Efferon LPS
- Where
- 3 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Efferon JSC
Multiple Organ Failure
Use of Extracorporeal Treatment With the Cytosorb-Adsorber for the Reduction of SIRS in Heart Surgery Patients
Heart-surgery with the use of a heart-lung-machine can trigger the development of a full-blown SIRS (Systemic Inflammatory Response Syndrom) with multi organ failure and severe sepsis in the course of disease.
- Trial name
- CASHSP (NCT02265419)
- Testing
- Extracorporeal treatment with the Cytosorb adsorber
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Rostock
Tennis Elbow
Non-Surgical Treatment Approaches in Patients With Newly Diagnosed Lateral Epicondylitis: A Randomized Clinical Trial
Lateral epicondylitis (tennis elbow) is a painful musculoskeletal condition, which is considered to be due to overuse, over-stress or over-exertion of the wrist extensors of the forearm, especially extensor carpi radialis brevi.
- Trial name
- NCT02930304
- Testing
- first physiotherapy, second physiotherapy, third physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Hacettepe University
Inflammation, Systemic Inflammatory Response Syndrome
Inflammatory Response in Aortic Valve Replacement
The study investigates inflammatory and antiinflammatory response in patients with severe aortic valve stenosis needing either surgical treatment (surgical aortic valve replacement) or interventional cardiology treatment…
- Conditions
- Inflammation, Systemic Inflammatory Response Syndrome, Thoracic Surgery, Aortic Valve Stenosis
- Trial name
- NCT02324140
- Testing
- Whole blood analysis
- Where
- Switzerland
- Volunteers
- 101 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obstructive Sleep Apnea
The Impact of Fluid Volume Shifts on Upper Airway Collapse and Obstructive Sleep Apnea in Surgical Patients
The objective of this study is to examine the contribution of intravenous (IV) fluid administration and rostral fluid shift from the legs to the neck thereby leading to worsening of sleep apnea following surgery.
- Trial name
- NCT03850041
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Aortic Dissection, Systemic Inflammatory Response Syndrome
Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular Surgery (PANDA VI)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with cardiovascular diseases.
- Conditions
- Aortic Dissection, Systemic Inflammatory Response Syndrome, Cardiovascular Diseases (CVD)
- Trial name
- PANDA (NCT06195267)
- Testing
- Sivelestat, Blank control
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Systemic Inflammatory Response Syndrome, Sepsis
Persistent Multiorgan Failure in Intensive Care Units
Multiorgan failure (MOF) as a result of any critical condition is a complex set of immunological and biochemical interactions leading to death in patients who are effectively subjected to primary resuscitation (correction of…
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Multiorgan Failure
- Trial name
- PROPOSe (NCT03604731)
- Testing
- cytokine adsorbtion during extracorporeal circulation
- Volunteers
- 300 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Shock
The Prevalence of the Aortic to Radial Pressure Gradient in States of Shock, Outside the Context of Cardiac Surgery, a Prospective Study
First described in cardiac surgery, the aortic to radial pressure gradient (ATRAP) is the cause of an underestimation of the aortic pressure with a measure assumed with a radial catheter, and he can concert 1 of 3rd patients.
- Trial name
- PARECHOC (NCT06460519)
- Testing
- Non-invasive blood pressure measurements
- Where
- 9 sites in France, Guadeloupe
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Infection After Transfusion, Transfusion-related Immunomodulation Reaction
Blood Transfusions and Immune Response
We have previously reported the results of the primary and secondary outcomes of a randomized study aiming to investigate the impact of a restrictive transfusion protocol on the magnitude of reduction in blood transfusion in a…
- Conditions
- Infection After Transfusion, Transfusion-related Immunomodulation Reaction, Cytokine Storm, Surgery
- Trial name
- NCT02020525
- Testing
- restrictive transfusion strategy, liberal transfusion strategy
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- Aretaieion University Hospital
Shock
High Volume Veno-venous Hemofiltration Versus Standard Care for Post-cardiac Surgery Shock
This study seeks to determine if early continuous High Volume Veno-venous Hemofiltration (HVHF) reduces 30-day all cause mortality in post-cardiac surgery patients developing shock requiring high doses catecholamines.
- Trial name
- HEROICS (NCT01077349)
- Testing
- high volume hemofiltration, standard care
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Acute Kidney Injury, Cardiogenic Shock
Acute Kidney Injury in Adult Patients Supported by VA-ECMO
Post-cardiotomy cardiogenic shock (PCCS) occurs in 2-6% of patients undergoing cardiac surgery, and 1% of cardiac surgery patients will require mechanical circulatory support using Veno-Arterial ExtraCorporeal Membrane…
- Trial name
- AKI-ECMO (NCT04082312)
- Testing
- No intervention
- Where
- France
- Volunteers
- 347 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response.
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative
- Trial name
- NCT05172739
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Crete