Clinical trials: Shock Liver
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Acute on Chronic Liver Failure
Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock
ACLF is defined differently in APASL,EASL and AASLD.APASL talks of reversibility in ACLF as per its definition and constitution of Homogenous population with ACLF.The definition of ACLF as per APASL is an acute hepatic insult…
- Trial name
- NCT06556472
- Testing
- Terlipressin, Norephrine
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
Impact of Continuous Renal Replacement Therapy on Systemic Hemodynamics and Lactate Clearance in Critically Ill Cirrhotics With Septic Shock.
Consecutive critically ill cirrhotics with septic shock and AKI who give written informed consent will be included in this prospective study.
- Trial name
- NCT04949178
- Testing
- No intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Liver Failure, Cerebral Edema
High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral Edema
In this prospective randomized controlled trial Investigator aim to evaluate the impact of high versus standard volume plasma-exchange in patients with acute liver failure with cerebral edema and clinical outcomes.
- Trial name
- NCT06515145
- Testing
- High Volume Therapeutic Plasma Exchange, Standard volume therapeutic plasma exchange
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Septic Shock, Vasoplegia
Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue
Mortality rates associated septic shock remains unacceptably high, around 20-50%, with refractory hypotension in half of these patients.
- Conditions
- Septic Shock, Vasoplegia, Cirrhosis, Liver, Refractory Shock
- Trial name
- CRuMBS (NCT03120637)
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 111 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Liver, Cirrhotic Cardiomyopathy
Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and…
- Conditions
- Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock
- Trial name
- ECLIPSE-I (NCT07286643)
- Testing
- POCUS, Fixed Resuscitation Strategy based on Target MAP
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Liver Transplantation, Shock
Hemodynamic Profiles and Macro-Microcirculatory Coherence in Liver Transplantation: an Integrative Approach in the Immediate Postoperative Period
Hemodynamic instability is a common and serious condition in patients undergoing liver transplantation and is associated with increased morbidity and mortality if not promptly recognized and treated.
- Conditions
- Liver Transplantation, Shock, Hemodynamic Instability
- Trial name
- COHERENCE-LT (NCT07547020)
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital El Cruce
Liver Insufficiency, Kidney Failure, Chronic
Quantification of Drugs and Their Degradation Products
The study includes two study parts in which blood is collected from the patients. Study part A (observational study, already received positive ethics committee vote; Our sign: 12-330): Use of blood samples gathered during routine…
- Conditions
- Liver Insufficiency, Kidney Failure, Chronic, Obesity, Pregnancy
- Trial name
- NCT01828372
- Testing
- additional blood withdrawals
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University of Cologne
Sepsis, Liver Failure
Lactate Clearance According to the Presence of Hepatic Dysfunction
The purpose of this study is to compare lactate clearance in patients with severe sepsis and septic shock according to the presence of hepatic dysfunction.
- Trial name
- NCT01709565
- Where
- South Korea
- Volunteers
- 245 people
- Sponsor
- Samsung Medical Center
Septic Shock, Cirrhosis, Liver
Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response. A Subset of sepsis is septic shock which has almost 4-6 times the mortality when compared to sepsis.
- Trial name
- NCT05315557
- Testing
- Terlipressin, vasopressin
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Heat Stroke, Early Waking
Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs.
- Conditions
- Heat Stroke, Early Waking, MODS, Proteinosis
- Trial name
- NCT05155358
- Testing
- Peripheral blood test
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
Liver Failure, Acute on Chronic
Chinese CLIF-C Acute-on-Chronic Liver Disease and Liver Failure Study
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC (NCT02457637)
- Testing
- Standary therapy
- Where
- 16 sites in China
- Volunteers
- 2,600 people
- Sponsor
- Hai Li
Septic Shock and Acute Kidney Injury
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS.
- Trial name
- NCT03343340
- Testing
- Early CRRT, Late CRRT, Standard Medical Therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Multiple Organ Failure
TPE in Septic Patients and Influence on Organ Failure
Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study focusing on the organ functions of the patients.
- Trial name
- TPEMOF (NCT02906345)
- Testing
- Therapeutic Plasma Exchange (TPE)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Rostock
Liver Cancer
GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Liver Cancer
This trial is to further study the safety and effectiveness of autologous gp96 treatment of liver cancer on the basis of preliminary work
- Trial name
- NCT04206254
- Testing
- gp96
- Volunteers
- 80 people
- Sponsor
- Cure&Sure Biotech Co., LTD
Hypoxic Hepatitis, Ischemic Hepatitis
Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis
Hypoxic hepatitis (HH) is reported to be the most frequent cause of elevated aminotransferase levels in hospital. Up to 10 % of critically ill patients develop HH during the course of their intensive care unit (ICU) stay.
- Conditions
- Hypoxic Hepatitis, Ischemic Hepatitis, Shock Liver, Hypoxic Liver Injury
- Trial name
- MARS in HH (NCT01690845)
- Testing
- MARS
- Where
- 2 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Liver Cancer, Pancreatic Adenocarcinoma
Immunotherapy of Tumor With Autologous Tumor Derived Heat Shock Protein gp96
To evaluate the safety and effectiveness of autologous gp96 treatment of liver cancer and Pancreatic Adenocarcinoma
- Trial name
- NCT02133079
- Testing
- autologous gp96 vaccination
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Cure&Sure Biotech Co., LTD
SIRS, Sepsis
Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU)
In this study patients with 1. chronicle liver diseases primary biliary cirrhosis primary sclerosing cholangitis alcoholic liver cirrhosis hepatitis b or C Wilson's disease cryptogenic cirrhosis 2.
- Conditions
- SIRS, Sepsis, Liver Disease
- Trial name
- NCT01169168
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Johann Wolfgang Goethe University Hospital