Clinical trials: Shock Lung
Acute Respiratory Distress Syndrome
Discovery of New Early Detection Biomarkers of Acute Respiratory Distress Syndrome
The goal of this project is to find a series novel biomarkers by differential proteomic techniques that can improve the early diagnosis and develop a more efficient therapy to enhance ARDS patient survival rate.
- Trial name
- ARDS (NCT02625064)
- Testing
- Blood samples collection before treatment, Blood samples collection after treatment, laboratory biomarker proteomic analysis
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangya Hospital of Central South University
SARS-CoV 2 Pneumonia
Long Term Effects of Awake Prone Positioning in COVID-19 ICU Patients
Long term follow up of patients included in a randomized controlled trial evaluating awake prone positioning among patients suffering SARS-CoV2 pneumonia (NCT04358939)
- Trial name
- Long-termAPP (NCT06080737)
- Testing
- quality of life questionnaire
- Where
- France
- Volunteers
- 137 people
- Sponsor
- University Hospital, Tours
Acute Respiratory Distress Syndrome (ARDS)
Ultraprotective Lung Ventilation With Respiratory Extracorporeal Life Support for ARDS
Acute respiratory distress syndrome (ARDS) accounts for approximately 10% of all ICU admissions and 23% of patients requiring mechanical ventilation (MV).
- Trial name
- NOVAEOLIA (NCT07516665)
- Testing
- ECLS
- Volunteers
- 290 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome, Cardiac Failure
Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients
Patients in end-stage cardiac failure and/or respiratory failure may be started on a rescue therapy known as Extracorporeal Membrane Oxygenation (ECMO).
- Conditions
- Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure
- Trial name
- IGNITE (NCT04669444)
- Testing
- Ventilator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Moderate to Severe Acute Respiratory Distress Syndrome
Effects on Biotrauma of NMBAs and PP Association During ARDS
The improved survival of patients with acute respiratory distress syndrome (ARDS) over the last decades is related to the use of so-called "protective" mechanical ventilation.
- Trial name
- CURA-PRONE (NCT06212492)
- Testing
- NMBAs, Prone positioning
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Sepsis
Biomarkers to Predict Acute Respiratory Distress Syndrome(ARDS) in Patients With Sepsis
Sepsis-induced acute respiratory distress syndrome (ARDS) is a life-threatening acute inflammatory lung injury, associated with increased pulmonary microvascular permeability, increased lung weight, and loss of aerated lung…
- Trial name
- NCT05914428
- Testing
- ALDH2 rs671 mutation
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Qilu Hospital of Shandong University
Critical Illness, Sleep
Sleep Intervention During Acute Lung Injury
The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis, using α2 adrenergic agent Dexmedetomidine, on sleep and inflammation in critically ill patients with Acute Lung Injury and…
- Conditions
- Critical Illness, Sleep, Acute Lung Injury, Acute Respiratory Distress Syndrome
- Trial name
- NCT01050699
- Testing
- Dexmedetomidine, Midazolam and Fentanyl
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Acute Respiratory Distress Syndrome
Human Umbilical Cord Mesenchymal Stem Cells (MSCs) Therapy in ARDS
Acute respiratory distress syndrome (ARDS) is a devastating inflammatory and destructive disease in critical ill patients. Preclinical studies have shown a promising perspective of mesenchymal stem cells (MSCs) therapies in ARDS.
- Trial name
- ARDS (NCT03608592)
- Testing
- umbilical cord derived mesenchymal stem cells (UCMSCs) suspension, normal saline
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Sun Yat-sen University
Endocan, Copeptin
Endocan and Copeptin Serum Levels in Preterm Neonates With Respiratory Distress Syndrome
This work aims to investigate and compare the levels of serum endocan and serum copeptin on the first day of life and correlate their levels to the severity of respiratory distress in preterm neonates suffering from respiratory…
- Conditions
- Endocan, Copeptin, Serum, Preterm Neonates
- Trial name
- NCT07154134
- Testing
- Serum endocan, Serum copeptin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Respiratory Failure, Acute Respiratory Distress Syndrome
Cross-section Survey of Mechanical Ventilation and Acute Respiratory Distress Syndrome in China
The characteristics and outcomes of a mixed group of critically ill patients who received mechanical ventilation are not known in China.
- Trial name
- NCT01666834
- Where
- China
- Volunteers
- 555 people
- Sponsor
- Southeast University, China
Premature Birth
Effects of L-Carnitine Supplementation on Respiratory Distress Syndrome
The aim of the present study was to investigate the efficacy of L-carnitine therapy on the occurrence and prognosis of respiratory distress syndrome
- Trial name
- NCT03630367
- Testing
- Dexamethasone, L-Carnitine 1G/5mL Injection
- Where
- Egypt
- Sponsor
- Assiut University
ARDS
The Evaluation of NETs, Caspase-1 and Cytokines in ARDS Patients
1. enrollment criteria and clinical data collection: follow the principles of medical ethics, the development of inclusion and exclusion criteria, select 90 cases of ARDS patients, in the active treatment at the same time…
- Trial name
- NCT03227107
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (>6 hours of life).
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant, Transient Tachypnea of the Newborn, Meconium Aspiration Syndrome
- Trial name
- NCT07344714
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Respiratory Distress Syndrome, Adult
The Strategy of "Pulmonary Opening by Titration of Positive End-expiratory Pressure" Means of a Pulmonary Recruitment Maneuver in Patients With Acute Respiratory Distress Syndrome: for Which Patients?
Pulmonary recruitment maneuvers open these lung areas and appropriate adjustment of positive expiratory pressure (PEP) helps to stabilize recruitment and reduce the stress associated with alveolar opening and closing.
- Trial name
- OPPRED (NCT04028336)
- Testing
- TITRATION
- Where
- 4 sites in France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier de Lens
Mesenchymal Stromal Cells, Remestemcel-L
MSCs in COVID-19 ARDS
The mortality rate in SARS-CoV-2-related severe ARDS is high despite treatment with antivirals, glucocorticoids, immunoglobulins, and ventilation.
- Conditions
- Mesenchymal Stromal Cells, Remestemcel-L, Acute Respiratory Distress Syndrome, COVID
- Trial name
- NCT04371393
- Testing
- Remestemcel-L
- Where
- 21 sites in United States
- Volunteers
- 223 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lung Ultrasound, Respiratory Distress Syndrome, Newborn
Bedside Ultrasound to Monitor Lung Function and Blood Flow in Newborns Treated With Surfactant
The ULISSES study looks at how doctors use bedside ultrasound to help treat premature babies with breathing problems caused by Respiratory Distress Syndrome (RDS).
- Trial name
- ULISSES (NCT07070167)
- Testing
- Intratracheal administration of surfactant
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Chiesi Poland Sp. z o.o.
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Blunt Chest Trauma, Acute Respiratory Distress Syndrome
Statins and Selective Cyclooxygenase-2 Receptor Inhibitors in Blunt Chest Trauma
Background: Lung contusion affects 17%-25% of adult blunt trauma patients, and is the leading cause of death from blunt thoracic injury.
- Trial name
- NCT01623921
- Testing
- standard care treatment, Celecoxib, Rosuvastatin
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
COVID-19, Mechanical Ventilation
Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome
This multicentric prospective clinical practice study aims at evaluating clinical factors associated with a prolonged invasive mechanical ventilation and other outcomes such as mortality and ICU length of stay in patients…
- Conditions
- COVID-19, Mechanical Ventilation, Quality of Life, Radiologic Increased Density of Lung
- Trial name
- NCT04411459
- Testing
- Invasive mechanical ventilation
- Where
- 20 sites in Italy
- Volunteers
- 470 people
- Sponsor
- Azienda Usl di Bologna
Premature Infant, Respiratory Distress Syndrome
The Hilo Pilot -Trial to Assess Feasibility
Preterm birth, or birth before 37 weeks' gestation, is increasingly common, occurring in 8% of pregnancies in Canada. Preterm birth is associated with many health complications, particularly when the birth happens before 29…
- Trial name
- HiLo-Pilot (NCT03706586)
- Testing
- 30% group, 60% group
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Alberta