Clinical trials: Short Gut
Executive Function
The Effects of Short-Chain Fatty Acids in Psychosocial Stress-Induced Impairment on Core Executive Functions
The aim of the present trial is to examine core executive functions (EFs) as a functional outcome of attenuating the cortisol response to acute laboratory stress through colonic delivery of an Short Chain Fatty Acids (SCFAs) mix…
- Trial name
- GUTSIE (NCT06286943)
- Testing
- Short Chain Fatty Acids (SCFAs)., Maastricht Acute Stress Task, No-stress control task
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bowel Preparation Scale, Adenoma Detection Rate
Impact of Reinforced Education by Wechat and Short Message Service on the Quality of Bowel Preparation
High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of reinforced education by Wechat or short message service (SMS) on the quality of bowel preparation.
- Trial name
- NCT02832869
- Testing
- short message service based re-education, Wechat based re-education
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Irritable Bowel Syndrome (IBS)
Irritable Bowel Syndrome and Control Volunteers: Diet Challenge
The study will investigate the relationship between fecal bile acids, short-chain fatty acids (SCFAs), and the gut microbiota in irritable bowel syndrome (IBS).
- Trial name
- NCT06668922
- Testing
- Inulin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity, Diabetes
Acute Effects of Dietary Fiber on Postprandial Responses in Lean and Overweight Subjects
It has been suggested that obesity occurs because the colonic microbes in obese individuals, compared to those who are lean, produce more short chain fatty acids during the fermentation of dietary fiber; this means that obese…
- Trial name
- NCT02795559
- Testing
- Glucose, Inulin, Resistant starch
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Colorectal Polyp, Colorectal Cancer
Detection of Endoscopic Resection Scars and Delineation of Recurrence is Trainable
Colorectal cancer is prevented by colonoscopy and polypectomy. Failure to recognize the endoscopic resection scar after Endoscopic Mucosal Resection (EMR) risks unrecognized recurrent or residual adenoma (RRA), which may…
- Trial name
- SCAR (NCT06193356)
- Testing
- Learning tool
- Where
- Belgium
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Overweight and Obesity
Plasma SCFAs After Fermentable Cereal Fibres - A Postprandial Study
Circulating SCFAs reflect the net effect of what is produced in the large intestine from dietary fibre fermentation, bioavailability after considerable absorption by the enterocytes and in the liver and the elimination.
- Trial name
- FIFERM (NCT05443828)
- Testing
- Breakfast Control Meal, Breakfast Test Meal
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy Volunteers, Stress
Effects of Rifaximin on Gut Microbiota and Emotion
A randomized, triple-blind, placebo-controlled study on the effect of rifaximin on psychobiological functions in healthy men.
- Conditions
- Healthy Volunteers, Stress, Fear
- Trial name
- NCT05587036
- Testing
- Rifaximin
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Short Bowel Syndrome
Energy Metabolism in Patients With Short Bowel Syndrome
This study proposes to verify the total energy expenditure in patients with short bowel syndrome using the doubly labeled water method, as well as determining the rate of oxidation of nutrients, aiming to assist the management of…
- Trial name
- NCT02113228
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Sports Nutrition, Biochemical Markers
Effect of a Short-term Multi-strain Probiotic Supplementation in Endurance Athletes
The aim of this project is to evaluate and identify the effect of a short-term 2-week multi-strain probiotic (MPRO) supplementation on the exercise-associated gastrointestinal (GI) symptoms and perturbations in high level female…
- Conditions
- Sports Nutrition, Biochemical Markers, Exercise Performance, Aerobic Capacity
- Trial name
- NCT07252778
- Testing
- MPRO supplementation
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Krzysztof Durkalec-Michalski
Short Bowel Syndrome
Plasma Determination of Glucagon-like Peptide 2 as a Predictor of Recovery in Adults With Acute Intestinal Failure
The purpose of this study is to investigate the theory that the plasma level of Glucagon like peptide 2 (GLP-2) in patients with intestinal failure can predict their clinical recovery.
- Trial name
- NCT00180648
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Appetite Regulation
The Effects of Rye Crisp Bread on Appetite and Metabolic Function
The aim of this study is to contribute to a better understanding of how dietary fibre in rye affects appetite and metabolic processes.
- Trial name
- S2RBAM (NCT02011217)
- Testing
- Rye crisp bread A, Rye crisp bread B, Wheat crisp bread C
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Swedish University of Agricultural Sciences
Diet Habit
Arbutus Berry - Intervention Study to Evaluate the Modulation of Intestinal Microbiota and Metabolic Parameters
The tree that produces the arbutus berry, the strawberry tree, scientific name Arbutus unedo L., belongs to the family of Ericaceae.
- Trial name
- F4F (NCT05810922)
- Testing
- arbutus berry
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Bloodstream Infections, Short Bowel Syndrome
Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome Infants
The purpose of this research study is to evaluate the effects (good and bad) of supplementation with Glutamine to that of a placebo (L-alanine), on your child and their Short Bowel Syndrome.
- Conditions
- Bloodstream Infections, Short Bowel Syndrome, Development, Nutrition
- Trial name
- NCT01576003
- Testing
- Glutamine, L-alanine
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Short Gut Syndrome
Fiber Food Introduction in Pediatric Short Bowel Syndrome
Short bowel syndrome (SBS) is a rare but challenging condition in which patients have insufficient bowel length to meet fluid, electrolyte, and nutrient requirements without parenteral support.
- Trial name
- NCT05432648
- Testing
- Green bean puree
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Arterial Stiffness, Dysbiosis
Intestinal Microbiota and Arterial Stiffness
This is an observational case-control study which objective is to analyse differences in intestinal microbiota between patients with and without arterial stiffness, measured by pulse wave velocity.
- Trial name
- MIVAS (NCT03900338)
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Parkinson Disease
Effects of Resistant Starch on Bowel Habits, Fecal Short Chain Fatty Acids and Gut Microbiota in Parkinson Disease
The investigators will investigate the effects of an 8-week resistant starch (RS) supplementation (5 g twice a day) in patients with Parkinson Disease and matched controls on: 1.
- Trial name
- RESISTA-PD (NCT02784145)
- Testing
- Resistant starch, Recommendation with regard to nutrition
- Where
- Germany
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Universität des Saarlandes
Microbiome Related Mechanisms Linked to Early Onset Colorectal Cancer
The EAT-FIBRE Study.
The goal of this clinical trial is to understand whether diet can impact mechanisms linked to early-onset colorectal cancer. The main question it aims to answer is: does a high-fibre modified EatWell diet improve stool, blood…
- Trial name
- EAT-FIBRE (NCT07279454)
- Testing
- Modified EatWell diet, EatWell diet
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King's College London
Human Microbiome
Microbiome Composition Changes on 4 Week Gluten-free Diet Challenge
Changes in the gut microbiomes of healthy volunteers who followed a gluten-free diet (GFD) for four weeks were studied. Per participant, nine stool samples were collected: one at baseline, four during the GFD period, and four…
- Trial name
- NCT02731976
- Testing
- Dietary intervention
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Systemic Availability, Intestinal Absorption
The Systemic Concentration of Short-Chain Fatty Acids After Delivery in the Small and Large Intestine of Healthy Volunteers
The goal of this crossover study is to evaluate the systemic availability of short-chain fatty acids (SCFA) that are either administered in the small intestine or the colon in healthy volunteers.
- Conditions
- Systemic Availability, Intestinal Absorption, Metabolism, Short-chain Fatty Acids
- Trial name
- Sistine (NCT06082726)
- Testing
- SCFA
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- KU Leuven