Clinical trials: Short-chain Fatty Acids
Quality of Life
Effect of Colon Delivered Vitamin C on Gut Microbiota and Related Health Biomarkers in Healthy Older Adults
Recent studies have shown that many vitamins, if consumed in high daily dosages or delivered to the colon, can modulate the gut microbiota and their metabolites.
- Trial name
- NCT05598619
- Testing
- Vitamin C
- Where
- Ireland
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Stress, Healthy Volunteers
Brain Responses to Short-Chain Fatty Acid Intervention
A randomized, triple-blind, placebo-controlled study on the effect of colon-delivered short-chain fatty acids (SCFAs) on neural responses to stress and neuroepigenetics.
- Trial name
- MoodBugs HDAC (NCT06546683)
- Testing
- Short-Chain Fatty Acids
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Skin Dryness
Glyceryl Eicosapentaenoate Based Topic Products as an Irritant-free Cream and Serum for Hydration of Sensitive Skin
This exploratory study aims to verify the hydrating potential as well as the possible irritant effects of a 14-day hydrating treatment consisting of daily application of serum and cream to the skin of two dry targeted areas.
- Trial name
- COS-PBP-01 (NCT06219213)
- Testing
- Glyceryl Eicosapentaenoate serum, Glyceryl Eicosapentaenoate Cream A, Glyceryl Eicosapentaenoate Cream B
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- SCF Pharma
Type2diabetes, Heart Failure With Preserved Ejection Fraction
Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)
The study team is studying how increasing dietary fiber, specifically through adding potato starch to participant's diet, may impact the species of bacteria in participant's gut microbiome.
- Trial name
- NCT06337812
- Testing
- Potato Starch
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Coronary Arterial Disease (CAD)
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients
The development of atherosclerosis is significantly influenced by the interplay between lipid and inflammatory factors. Endotoxemia, defined as the presence of endotoxins, particularly lipopolysaccharides (LPS) derived from…
- Trial name
- NCT06747234
- Testing
- Oat bran group, Control (Standard treatment)
- Where
- 2 sites in Iran
- Volunteers
- 32 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Healthy
In Vivo Quantification of Short Chain Fatty Acids Production in the Human Colon
During this project the amount of SCFA produced in the colon after consumption of 2 different 13C-labelled wheat fiber fractions will be quantified.
- Trial name
- NCT02378376
- Testing
- Arabinoxylan oligosaccharides, Dietary fiber enriched bran
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Chronic Obstructive Pulmonary Disease
Short Chain Fatty Acid Metabolism in COPD
The short chain fatty acid (SCFA) metabolism has not been studied in subjects suffering from COPD. The purpose of this study is to compare the SCFA metabolism in COPD patients to healthy matched controls.
- Trial name
- SCFA (NCT03327181)
- Testing
- short chain fatty acid tracers
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Healthy
Towards a Food Ingredient Clinically Proven to Benefit Gut Health: Novel RG-I Variants
The aim of this study is to determine, quantify and understand the potential prebiotic effects of RG-I variants via microbiota modulation. The anti-inflammatory potential effects of these variants will also be investigated.
- Trial name
- NUTRIGUT (NCT06081972)
- Testing
- Maltodextrin, Chicory RG-I, Carrot RG-I
- Where
- Sweden
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Healthy
Effects of the Short-Chain Fatty Acids-Targeted Dietary Interventions on the Selected Autonomic Functions in Humans
Recent data feature short-chain fatty acids (SCFAs), products of gut microbial fermentation, as modulators of the blood pressure of the host.
- Trial name
- NCT06851039
- Testing
- Potato starch supplementation, Sodium butyrate supplementation, Accessible starch supplementation
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
IBS - Irritable Bowel Syndrome
Irritable Bowel Syndrome and Control Volunteers: Diet Challenge
The purpose of this study is to study the relationship between the bile acids, short chain fatty acids and bacteria within the intestines.
- Trial name
- NCT03983434
- Testing
- Inulin
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
TB - Tuberculosis, HIV/AIDS
Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis
The diverse microbial communities in different parts of the human body (microbiome) are important for health but understudied in pulmonary tuberculosis (TB), which is the single biggest infectious cause of death in the world.
- Trial name
- TB-LUNG (NCT04700579)
- Where
- 3 sites in South Africa
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
Executive Function
The Effects of Short-Chain Fatty Acids in Psychosocial Stress-Induced Impairment on Core Executive Functions
The aim of the present trial is to examine core executive functions (EFs) as a functional outcome of attenuating the cortisol response to acute laboratory stress through colonic delivery of an Short Chain Fatty Acids (SCFAs) mix…
- Trial name
- GUTSIE (NCT06286943)
- Testing
- Short Chain Fatty Acids (SCFAs)., Maastricht Acute Stress Task, No-stress control task
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Metabolic Effects, Immunosuppressive Agents
Impact of SCFA Supplementation on Gut Microbiome Composition of Kidney Transplant Recipients
This is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effects of high-dose short-chain fatty acid (SCFA) supplementation on the gut microbiome and host metabolome in stable kidney…
- Conditions
- Metabolic Effects, Immunosuppressive Agents, Renal Function, Adverse Events
- Trial name
- RENOBIOME (NCT07024238)
- Testing
- SCFA
- Where
- Slovakia
- Volunteers
- 41 people
- Sponsor
- University Hospital, Martin
Obesity & Overweight, Metabolic Syndrome
Kodo Millet Porridge and Its Effects on Gut Health and Metabolic Syndrome
Dietary fiber are components in foods that are not digested by human gastrointestinal enzymes (alpha amylase and alpha glucosidase) but are instead broken down and fermented by gut microbes.
- Conditions
- Obesity & Overweight, Metabolic Syndrome, Gut Dysbiosis, Insulin Resistance
- Trial name
- KMGMS (NCT07703371)
- Testing
- Kodo Millet Porridge Beverage
- Where
- India
- Volunteers
- 50 people
- Sponsor
- JSS MEDICAL COLLEGE, JSS ACADEMY OF HIGHER EDUCATION AND RESEARCH
Parkinson Disease
Prebiotics in the Parkinson's Disease Microbiome
There are about one million Parkinson's disease (PD) patients in America. The risks associated with whether or not an individual may develop PD include environment and genetic (biologic, hereditary) factors.
- Trial name
- NCT04512599
- Testing
- Prebiotic Bar
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rush University Medical Center
Overweight and Obesity
Plasma SCFAs After Fermentable Cereal Fibres - A Postprandial Study
Circulating SCFAs reflect the net effect of what is produced in the large intestine from dietary fibre fermentation, bioavailability after considerable absorption by the enterocytes and in the liver and the elimination.
- Trial name
- FIFERM (NCT05443828)
- Testing
- Breakfast Control Meal, Breakfast Test Meal
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University