Clinical trials: Sialorrhea
Sialorrhea, Parkinson's Disease
Study of Glycopyrrolate for Moderate-to-severe Sialorrhea in Parkinson's Disease
Sialorrhea is a frequently occurring problem with detrimental effect on quality of life in 25% of PD patients. Currently, there is no intervention approved for sialorrhea in Parkinsons and evidence is only available for a 30-day…
- Trial name
- GLYCOPAR (NCT02382198)
- Testing
- Glycopyrrolate
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Ottawa Hospital Research Institute
Parkinson Disease
STN-DBS and the Risk of Sialorrhea
OBJECTIVE: The aims of this study were to assess the incidence rate and risk factors for sialorrhea in the long-term follow-up in a cohort of 170 patients with advanced Parkinson's disease [84 with deep brain stimulation (DBS)…
- Trial name
- NCT06090929
- Testing
- STN-DBS
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Qilu Hospital of Shandong University
Sialorrhea
Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease (PD)/Parkinsonism
This study is being conducted this study to determine whether injections of Xeomin®, a type of botulinum toxin into the glands that produce saliva (one pair just below and in front of the ear and the other just under the jaw…
- Trial name
- NCT01653132
- Testing
- Incobotulinum Toxin A
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sialorrhea, Neurodevelopmental Disorders
Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
Double blind, placebo-controlled, randomised trial, multicentre in France with open-label tolerability phase. The double-blind placebo-controlled study duration will be scheduled for 3 months with the final visit of the…
- Trial name
- SALIVA (NCT04873115)
- Testing
- Sialanar, Oral Rehabilitation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Proveca Pharma Limited
Sialorrhea True Bulbar Palsy Medullary Injury
A Clinical Study of Ultrasound-guided Botulinum Toxin A Into Salivary Gland for Sialorrhea After True Bulbar Palsy
Sialorrhea refers to a group of syndromes characterized by excessive saliva secretion from the salivary glands or reduced clearance of oral saliva due to dysphagia, resulting in saliva overflowing from the corners of the mouth or…
- Trial name
- NCT07070817
- Testing
- Ultrasound-Guided Botulinum Toxin Type A (BoNT-A) Salivary Gland Injection, Control (Normal saline)
- Where
- China
- Sponsor
- houyajing
Schizophrenia, Clozapine
The Treatment of 2 Chinese Medicines in Clozapine-induced Hypersalivation in Schizophrenia
The goal of this research is hoping to combine traditional Chinese medicine medication and find out how to solve clozapine-induced hypersalivation, also reduce side-effect, medication compliance, improving life quality, improving…
- Conditions
- Schizophrenia, Clozapine, Hypersalivation, Traditional Chinese Medicine
- Trial name
- NCT01045720
- Testing
- Suo Quan Wan, Wu Lin San
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Parkinson's Disease
Ipratropium Spray for Drooling Saliva in Parkinson's Disease
A phase II double blind clinical trial investigating the effects of ipratropium spray versus placebo spray in patients with Parkinson's disease.
- Trial name
- NCT00296946
- Testing
- ipratropium bromide (drug)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Sialorrhea
Botulinum Toxin-A for Sialorrhoea Treatment in Asian Adults With Neurological Diseases
The efficacy of Botulinum toxin A (BoNT-A) in Asian population has not been properly studied and there is no literature available on the most efficacious dose of BoNT-A for sialorrhoea treatment.
- Trial name
- NCT02425176
- Testing
- Botulinum toxin A (BoNT-A) 50U, Botulinum toxin A (BoNT-A) 100U, Botulinum toxin A (BoNT-A) 200U
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Crossbite, Openbite
Implications of Pacifier Use in Israeli Children
The purpose of this study is to examine pacifier sucking habits among children, and to assess implications of the oral habit - for example malocclusions and drooling.
- Conditions
- Crossbite, Openbite, Drooling
- Trial name
- NCT01249885
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Sialorrhea, Amyotrophic Lateral Sclerosis
Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related Sialorrhea
Evaluation of the decrease of the secretion of saliva in patients with amyotrophic lateral sclerosis by a local ultrasound-guided bilateral injection of botulinum toxin type A in parotids and submandibular glands.
- Trial name
- ALS-TOX (NCT01551940)
- Testing
- Botox injection
- Where
- 13 sites in France
- Volunteers
- 18 people
- Sponsor
- Hospices Civils de Lyon
Sialorrhea
Efficacy and Safety Study of MYOBLOC in the Treatment of Sialorrhea in Pediatric Subjects
This study will evaluate the efficacy and safety of MYOBLOC for the treatment of chronic sialorrhea in pediatric subjects.
- Trial name
- NCT05097079
- Testing
- MYOBLOC Low Dose, MYOBLOC High Dose
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Hypersalivation, Cerebral Palsy
Turkish Validation of The Drooling Impact Scale
The aim of this study is to investigate the reliability and construct validity of the Turkish version of the Drooling Impact Scale in children with cerebral palsy
- Trial name
- NCT04132765
- Testing
- Drooling Impact Scale, Drooling Frequency and Severity Scale, The Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD™)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Cerebral Palsy, Pathological Drooling
Management of Drooling in Children With Cerebral Palsy in France
The study is a transversal, observational, descriptive survey of the practices and opinions of health professionals carried out nationally across France that aims to characterize children with cerebral palsy and pathological…
- Trial name
- TOXSIALO (NCT02797106)
- Testing
- Practice survey of health professionals
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Sialorrhea, Neurologic Disorder
Safety and Efficacy of Cryoablation in Management of Sialorrhea in Patients With Neurological Disorders
To evaluate safety of cryoablation of submandibular glands in management of sialorrhea in neurologically impaired populations. Secondary Objective: To evaluate efficacy of cryoablation of submandibular glands in management of…
- Trial name
- SECAMS (NCT03704168)
- Testing
- CRYOABLATION
- Sponsor
- Dean Nakamoto
Cerebral Palsy, Excessive Crying
Excessive Crying in Children With Cerebral Palsy and Communication Deficits
Management of excessive crying in children with cerebral palsy and communication deficits [ECCCPCD] was guided by the associated clinical findings and investigations.
- Conditions
- Cerebral Palsy, Excessive Crying, Pain
- Trial name
- ECCCPCD (NCT04523935)
- Testing
- Baclofen, Diazepam, Clonazepam, Trihexyphenidyl, Tetrabenazine, Gabapentin, Topiramate, Lamotrigine, Amitriptyline.
- Volunteers
- 131 people
- Sponsor
- Sathbhavana Brain Clinic
Drooling
Effectiveness of Kinesiotaping and Manipulation Therapies in Drooling Management Among Children With Oral Dysphagia
Children suffering from neurological problems may have a common problem of drooling and dysphagia.There is high prevelance of neurological disorders in developing countries including Pakistan.Parents of children with disability…
- Trial name
- NCT04266626
- Testing
- kinesiotaping therapy, oral motor manipulation therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Isra University
Hypersalivation
Treatment of Clozapine-Induced Hypersalivation Ipratropium Bromide
Hypersalivation (Too much saliva) and drooling is a side effect experienced by 31% of people taking the antipsychotic clozapine.
- Trial name
- NCT00381589
- Testing
- ipratropium bromide 0.03% spray
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Centre for Addiction and Mental Health
Main Heading (Descriptor) Terms
Mid-and Long-term Efficacy of Ergot Alkaloids in the Treatment of Salivation in Patients With Parkinson's Disease.
Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease, the incidence of population over 60 years old in China is 1.37%, Parkinson's disease is often accompanied by various non-motor…
- Trial name
- NCT06035913
- Testing
- Dihydroergot mesylate
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Sialorrhea
Efficacy and Safety Study of MYOBLOC® in the Treatment of Sialorrhea in Adult Subjects
This study will evaluate the efficacy and safety of MYOBLOC in the treatment of Sialorrhea (drooling), which can be a symptom of many disease conditions. MYOBLOC will be injected directly into the salivary glands.
- Trial name
- MYSTICOL (NCT01994109)
- Testing
- MYOBLOC
- Where
- 34 sites in United States, Russia and 1 more
- Volunteers
- 187 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC
Sjögren's Syndrome, Xerostomia
The Effect of Chewing Gum, Exercises of the Tongue, Lip, Jaw on Salivation, Xerostomia, Dysphagia in Sjögren's Syndrome
Sjögren's syndrome (SS) is a chronic, systemic and autoimmune disease characterized by inflammation, fibrosis and dysfunction of exocrine glands such as tear and salivary glands.
- Conditions
- Sjögren's Syndrome, Xerostomia, Dysphagia, Salivary Flow Rate
- Trial name
- SS (NCT05680064)
- Testing
- Tongue, lip, chin exercise group
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Saglik Bilimleri Universitesi