Clinical trials: Sickle Cell Anaemia
Sickle Cell Disease, Sickle Cell Anemia
Microvascular Blood Flow in Sickle Cell Anemia
Sickle cell disease (SCD) is an inherited blood disorder that causes the red blood cells to change their shape from a round shape to a half-moon/crescent or sickled shape.
- Trial name
- NCT01566890
- Testing
- regadenoson infusion with contrast-enhanced ultrasound, contrast-enhanced ultrasound
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Versiti Blood Health
Sickle Cell Disease, Sickle Cell Anemia
Decision Aid for Therapeutic Options In Sickle Cell Disease
Sickle cell disease (SCD) is an inherited disorder with chronic multi-system manifestations affecting 100,000 individuals in the US, largely of minority origin and associated with substantial morbidity, premature mortality…
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Hemoglobin SS, Hemoglobin SC
- Trial name
- NCT02326597
- Testing
- Decision Aid Tool, Standard Practice
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Emory University
Sickle Cell Anemia
Study of Ventilatory Mechanics in Patients With Sickle Cell Anemia
The Sickle Cell Anemia (SCA) is a recessive genetic condition, monogenic, resulting in defects in the red cell structure. In the investigators' country, this disease affects about 3,000 children each year and is considered one of…
- Trial name
- SCA (NCT02565849)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Leukemia, Myeloid, Acute, Leukemia, B-cell
Precision Exercise in Children With Malignant Hemopathies
In the early years of life and during adolescence, physical activity is crucial for good development of motor skills. It is even more so for those children and young people who are forced to undergo anti-cancer therapies and…
- Conditions
- Leukemia, Myeloid, Acute, Leukemia, B-cell, Leukemia, T Cell, Lymphoma, Hodgkin
- Trial name
- SportTherapy (NCT04090268)
- Testing
- Sport Therapy
- Where
- Italy
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Healthy, Sickle Cell Disease
Study of Methodologies to Measure Blood Flow and Oxygenation in Adults With Sickle Cell Disease
The purpose of the study is to determine whether imaging techniques, such as magnetic resonance imaging (MRI), near infrared spectroscopy (NIRS), laser speckle contrast imaging (LSCI), and optical imaging (OI), can detect…
- Trial name
- NCT02447627
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Bioverativ Therapeutics Inc.
Thalassemia, Sickle Cell Disease
Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia
This is primarily an observational trial in patients with chronic anemia syndromes (sickle cell disease and thalassemia) and control subjects.
- Conditions
- Thalassemia, Sickle Cell Disease, Healthy Controls
- Trial name
- CVR (NCT03715972)
- Testing
- Hydroxyurea, Acetazolamide
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Sickle Cell Anemia, Blood Transfusion
Full Assessment of Clinical Transfusion Support
This study looks at why some children develop very severe anemia that leads to a blood transfusion. It also checks for diseases in the blood they receive.
- Conditions
- Sickle Cell Anemia, Blood Transfusion, Malaria Parasitaemia
- Trial name
- FACTS (NCT07094646)
- Where
- Uganda
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis, Hemophilia A
Medication Adherence and Non-adherence in Adults With Rare Disease
The purpose of this study is to use the Medication Adherence Reasons Scale (MAR-Scale) to determine the extent of non-adherence to specific medications indicated to treat cystic fibrosis, hemophilia (A or B), idiopathic pulmonary…
- Conditions
- Cystic Fibrosis, Hemophilia A, Hemophilia B, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT04541875
- Testing
- MAR-Scale
- Volunteers
- healthy volunteers welcome
- Sponsor
- Xperiome
Sickle Cell Disease, Cerebral Stroke
Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography
The purpose of the study protocol is to identify imaging biomarkers for brain tissue under high metabolic stress at risk for permanent injury.
- Trial name
- HDDOT CVR (NCT07776444)
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Sickle Cell Disease
Evaluating Thromboelastography (TEG) and ETP in Sickle Adults
The primary aim of this study is to investigate the reported enhanced coagulation status (prothrombotic status) in patients with sickle cell disease using 2 laboratory tests; thromboelastography (TEG) and Endogenous Thrombin…
- Trial name
- NCT02770534
- Testing
- blood test
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Sickle Cell Anemia, Sickle Cell Disease
Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose
The CADRE study is a multinational observational cohort of patients with sickle-cell disease (SCD) in five west and central sub-Saharan African countries.
- Trial name
- CADRE (NCT03114137)
- Where
- 13 sites in Cameroon, Côte d’Ivoire and 4 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Cardiologie et Développement
Sickle Cell Trait
Sickle Cell Trait in Football Players
This study will look at the five different types of sickle cell and their relation to self-reported ill health to determine whether or not one or two of the sickle cell haplotypes are correlated with worse health outcomes.
- Trial name
- NCT01891877
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Dyslipidemias, Hyperglycemia
Role of Ajwa Derived Polyphenols in Dyslipidaemias
World Health Organization report notifies of the escalating global burden of cardiovascular diseases (CVD), projecting that it will become the major worldwide cause of death and disability by 2020.
- Conditions
- Dyslipidemias, Hyperglycemia, Liver Dysfunction, Oxidative Stress
- Trial name
- NCT03805139
- Testing
- Ajwa Date (phoenix dactylifera)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Sickle Cell Disease
The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease
Sickle cell disease is an inherited blood disorder that affects red blood cells (RBCs). People with sickle cell disease frequently experience anemia, or a low number of RBCs.
- Trial name
- NCT00451919
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Self-Efficacy, Self-Care
Effect of Empowerment-Based Interventions on Self-Efficacy and Self-Care Capacity Among Adults With Sickle Cell Disease
This study aimed to To investigate the effect of empowerment-based interventions (EBI) on self-efficacy and self-care capacity among adults with Sickle Cell Disease (SCD).
- Trial name
- NCT06296654
- Testing
- Empowerment-Based Interventions, Standard Health Education
- Where
- Bahrain
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Bahrain
Sickle Cell Disease
Cardiovascular Complications of Sickle Cell Disease
In this research study, we are using heart imaging exams and blood testing, in order to gain an improved understanding of the pulmonary (lung) hypertension and cardiovascular (heart) complications that often occur in sickle cell…
- Trial name
- NCT01044901
- Testing
- MRI, Transthoracic Echocardiography, tonometry, EKG
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Sickle Cell Disease
Drug Interaction Study of GBT440 With Caffeine, S-warfarin, Omeprazole, and Midazolam in Healthy Subjects
The purpose of this study to evaluate the effect of concomitant administration of GBT440 on caffeine (a CYP1A2 probe substrate), S warfarin (a CYP2C9 probe substrate), omeprazole (a CYP2C19 probe substrate), and midazolam (a…
- Trial name
- NCT02567682
- Testing
- GBT440
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Global Blood Therapeutics
Dengue (Virus); Fever, Sandfly, Sickle Cell Disease
Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients
Dengue virus (DENV) belongs to the genus of Flavivirus transmitted by the mosquito Aedes aegypti and is responsible for an infectious disease associated with different forms and severities such as dengue hemorrhagic fever or…
- Trial name
- DREPADENGUE (NCT07000747)
- Where
- Guadeloupe
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Hemoglobinopathies, Thalassemia
Hemoglobinopathy Nursing Program and Pediatric Nursing Students
Hemoglobinopathies are the most common life threatening, monogenic disorders in the world. The most common causes of hemoglobinopathies are sickle cell disease and thalassemia.
- Conditions
- Hemoglobinopathies, Thalassemia, Sickle Cell Disease, Nurse's Role
- Trial name
- NCT05389891
- Testing
- Hemoglobinopathy Nursing Program
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Sickle Cell Anemia
Longitudinal Changes in Exercise Capacity in Children and Young Adults With Sickle Cell Anemia
The purpose of this study is to use comprehensive exercise testing to examine longitudinal changes in exercise capacity over a 2 year period in children and young adults with sickle cell anemia.
- Trial name
- NCT01558076
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago