Clinical trials: Sickle Cell Disorder
Anemia, Sickle Cell, Sickle Cell Anemia
Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis
Sickle Cell disease is caused by an inherited hemoglobin disorder. Healthy red blood cells are discoid and can deform and move through small blood vessels to carry oxygen to all parts of the body.
- Conditions
- Anemia, Sickle Cell, Sickle Cell Anemia, Sickle Cell Disease, Sickle Cell Disorders
- Trial name
- NCT01925001
- Testing
- MP4CO, Sodium chloride solution
- Where
- 14 sites in Bahrain, Belgium and 7 more
- Sponsor
- Sangart
Anemia, Sickle Cell, Hemoglobin SC Disease
Effectiveness of a Computerized Tool (PAINRelieveIt) to Help Manage Pain Related to Sickle Cell Disease
Sickle cell disease (SCD) is a blood disorder that is characterized by intense, painful episodes known as sickle cell crises. This study will evaluate the effectiveness of PAINRelieveIt, a three-part computer-based pain…
- Trial name
- NCT00600665
- Testing
- PAINReportIt (Phase 1 + 2), PAINUCope (Phase 1), PAINConsultN (Phase 2)
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- University of Illinois Chicago
Sickle Cell, Sickle Cell Disease
Sickle Cell, Pain and Mediterranean Diet
The goal of this study is to compare pain levels in individuals with Sickle Cell Disease while following the Mediterranean Diet to pain levels while following their usual diet.
- Conditions
- Sickle Cell, Sickle Cell Disease, Sickle Cell Disease Without Crisis, Mediterranean Diet
- Trial name
- MedSCP (NCT06886477)
- Testing
- Mediterranean Diet, Usual Diet
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Illinois Chicago
Sickle Cell Disease
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
- Trial name
- HOPE Kids 2 (NCT04218084)
- Testing
- Voxelotor
- Where
- 35 sites in United States, Egypt and 7 more
- Volunteers
- 236 people
- Sponsor
- Pfizer
Sickle Cell Disease
Cerebrovascular Reserve Measurements in Sickle Cell Disease
The primary aim of this study is to evaluate MRI-based cerebrovascular reserve (CVR) measurements in adult patients with Sickle Cell Disease (SCD).
- Trial name
- CRUISE (NCT02824406)
- Testing
- Acetazolamide
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sickle Cell Disease
Study of Safety and Efficacy of Genome-edited Hematopoietic Stem and Progenitor Cells in Sickle Cell Disease (SCD)
This study evaluated a genome-edited, autologous, hematopoietic stem and progenitor cell (HSPC) product - OTQ923 to reduce the biologic activity of BCL11A, increasing fetal hemoglobin (HbF) and reducing complications of sickle…
- Trial name
- NCT04443907
- Testing
- OTQ923
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Malaria, Sickle Cell Crisis
Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease
Malaria prophylaxis is recommended for sickle cell disease patients. In Nigeria, daily proguanil or weekly pyrimethamine are the most commonly prescribed regimens, but the current policy is not effective due to poor compliance…
- Trial name
- NCT01319448
- Testing
- Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine
- Where
- Nigeria
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Sickle Cell Disease (SCD)
Relationship Between Biological Phenotype, Clinical Severity of Sickle Cell Disease, and Blood Coagulation
Sickle cell disease is characterized by chronic hemolytic anemia and blood rheological alterations. In addition, blood coagulation abnormalities have been reported in patients with sickle cell disease and hemolysis-derived…
- Trial name
- DREPA COAG (NCT06619093)
- Testing
- blood sampling
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Stress, Job, PTSD
The Sequestration of Holistic Stress Management Techniques for Adults
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life.
- Conditions
- Stress, Job, PTSD, Hypervigilance, Hyperthyroidism
- Trial name
- NCT06098755
- Testing
- Holistic Medicine (HM)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Goddess Zena I. Jones
Thalassemia, Sickle Cell Anemia
Invasive Infections in Children With Hemoglobinopathies
Patients diagnosed as having hemoglobinopathies are exposed to serious bacterial infections, principally those patients that underwent splenectomy.
- Trial name
- NCT00456443
- Testing
- Historical records
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- HaEmek Medical Center, Israel
Sickle Cell Disease, Thalassemia
Effects of Transfusion of Older Stored Red Cells
The purpose of this study is to determine the effects of transfusion of fresh and stored blood on patients. The investigators hope to test: whether a similar effect (older stored blood is associated with worse outcomes) is seen…
- Trial name
- NCT01534676
- Testing
- Transfusion, Blood, Chelation therapy
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Columbia University
Sickle Cell Disease
Lung Ultrasound in Pediatric Acute Chest Syndrome
Sickle-cell disease is a common disease with serious complications, in particular acute chest syndrome (ACS), which can be life threatening.
- Trial name
- Lupacs (NCT06497153)
- Testing
- lung ultrasound
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Anemia, Beta-Thalassemia
Prevalence Of Microalbuminuria Among Children Suffering From Sickle Cell Nephropathy and Sickle Cell/Beta-Thalassemia
Sickle cell nephropathy is a known complication of sickle cell anemia (SCA) manifested by increase in glomerular filtration rate (glomerular hyperfiltration) and results in proteinuria and chronic renal failure.
- Conditions
- Sickle Cell Anemia, Beta-Thalassemia, Microalbuminuria
- Trial name
- NCT01092169
- Testing
- No intervention
- Sponsor
- Hillel Yaffe Medical Center
Sickle Cell Disease, Thalassemia
A Pilot Study of HSCT for Patients With High-risk Hemoglobinopathy Using a Nonmyeloablative Preparative Regimen
Hypothesis 1: A novel nonmyeloablative condition regimen will be safe and efficacious in producing stable donor chimerism and cure of severe hemoglobinopathy.
- Conditions
- Sickle Cell Disease, Thalassemia, Hemoglobinopathies
- Trial name
- NCT00427661
- Testing
- Busulfan; Fludarabine; cyclosporine A and MMF
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Sickle Cell Disease
PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Disease
To evaluate PK and PD responses to L-citrulline given orally for four weeks to patients with sickle cell disease who are otherwise healthy.
- Trial name
- NCT00343954
- Testing
- L-citrulline tablets, 1000 mg
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Angiogenix
Sickle Cell Disease
European Sickle Cell Disease Cohort - Hydroxyurea
In the context of the Risk Management Plan (RMP), as requested from Addmedica by the EMEA, to collect information about long-term safety of Siklos® (hydroxycarbamide) when used in patients with Sickle Cell Disease.
- Trial name
- ESCORT-HU (NCT02516579)
- Testing
- Siklos
- Where
- 60 sites in France, French Guiana and 5 more
- Volunteers
- 1,906 people
- Sponsor
- Theravia
Bone Marrow Transplantation, Sickle Cell Disease
Sickle Cell Disease Conditioning for Bone Marrow Transplant
Most bone marrow transplants for children with sickle cell disease are performed using high doses of two chemotherapy agents: busulfan and cyclophosphamide for the pre-transplant conditioning.
- Trial name
- NCT00968162
- Testing
- fludarabine
- Where
- 10 sites in United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Sickle Cell Disease, Pharmacokinetics
Pharmacokinetics and Safety of Endari (L-glutamine) in Sickle Cell Disease Patients
L-glutamine has been approved in the US to reduce the acute complications of sickle cell disease (SCD) in adult and pediatric patients 5 years of age and older.
- Trial name
- NCT04684381
- Testing
- L-glutamine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Emmaus Medical, Inc.
Healthy, Sickle Cell Anemia
Dose Escalation Study of PF-07209326 in Healthy Participants and Participants With Sickle Cell Disease
This Phase 1 first-in-human, first-in-patient, single ascending dose and multiple dose study will be a randomized, double-blind, placebo-controlled investigation of the safety, tolerability, and pharmacokinetics of PF-07209326 in…
- Trial name
- NCT04255875
- Testing
- PF-07209326
- Where
- 16 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Leg Ulcer, Sickle Cell Disease
Autologous Bone Marrow Stem Cells for Chronic Leg Ulcer Treatment in Sickle Cell Disease
The purpose of this study is to evaluate the safety and efficacy of autologous bone marrow stem cell implantation for the treatment of leg ulcer in adult patients with sickle cell disease.
- Trial name
- NCT02619734
- Testing
- Infusion of Autologous Bone Marrow Mononuclear Cells
- Volunteers
- 40 people
- Sponsor
- Federal University of Bahia
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