Clinical trials: Significant Coronary Artery Disease
Coronary Artery Disease
Clinical Significance of Platelet Reactivity on Clopidogrel During Off-pump Coronary Artery Bypass
Objective: To evaluate the early and late prognoses of patients according to platelet reactivity after clopidogrel administration and determine whether the measurement of platelet inhibition predicted 1-year clinical outcomes…
- Trial name
- NCT01959191
- Testing
- Dual antiplatelet therapy including aspirin and clopidogrel after off-pump coronary bypass surgery
- Where
- South Korea
- Volunteers
- 859 people
- Sponsor
- Yonsei University
Acute Coronary Syndrome
FFR-CT to Detect the Absence of Hemodynamically Significant Lesions in Patients With High-risk Acute Coronary Syndrome
The present study is a monocentric, observational, single arm, study, with the aim to determinate the ability of FFR-CT to exclude or confirm the presence of hemodynamically significant coronary stenosis, compared to coronary…
- Trial name
- NCT04052763
- Testing
- FFR-CT, FFRangio™
- Where
- Switzerland
- Volunteers
- 164 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiotoxicity, Atherosclerosis
Atherosclerosis in Chemotherapy-related Cardiotoxicity
Cardiological complications of oncological treatment, including the most serious of them cardiotoxicity and heart failure, constitute a significant and still unsolved clinical problem.
- Trial name
- ANTEC (NCT05118178)
- Testing
- echocardiography, computed tomography
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Coronary Artery Disease
Comparison Between Main Branch and Side Branch Vessels
The purpose of this trial is 1. to compare the clinical significance of the main vessel and the side branch vessel using EKG, pain score and coronary wedge pressure 2.
- Trial name
- NCT01046409
- Testing
- Measuring collateral flow
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Seoul National University Hospital
STEMI
Monocytosis and Culprit Vessel in STEMI Patients
Increased white blood cell count at the onset of an acute ST elevation myocardial infarction has been shown to be associated of increased incidence of heart failure and mortality.
- Trial name
- NCT01569646
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Northwell Health
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Coronary Artery Disease, Coronary Disease
Treatment of Functionally Non-significant Vulnerable Plaques in Patients With Multivessel ST-elevation Myocardial Infarction The VULNERABLE Trial
The study aims to compare a preventive percutaneous coronary intervention (PCI) plus optimal medical treatment (OMT) strategy vs.
- Conditions
- Coronary Artery Disease, Coronary Disease, Ischemic Heart Disease
- Trial name
- VULNERABLE (NCT05599061)
- Testing
- FFR>0.80+ OCT with findings indicative of vulnerable plaque
- Where
- 49 sites in Spain
- Volunteers
- 609 people
- Sponsor
- Fundación EPIC
Coronary Artery Disease
Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery
This observational prospective clinical study is to develop software tools to fuse coronary anatomy data obtained from CT coronary angiography with dynamic PET data to noninvasively measure absolute myocardial blood flow, flow…
- Trial name
- NCT04221594
- Testing
- Invasive Cardiac Catheterization (ICA), Coronary Computed Tomographic Angiogram (CCTA), Dynamic Cardiac Positron Emission Tomography (dPET)
- Where
- 6 sites in United States, South Korea
- Volunteers
- 68 people
- Sponsor
- Emory University
Fractional Flow Reserve, Myocardial, Coronary Artery Disease
Diagnostic Agreement of iFR and QFR.
A Prospective, observational, single center diagnostic study to investigate the the diagnostic agreement between QFR and the pressure wire-based iFR in a real world setting.
- Trial name
- DETECTISCHEMIA (NCT03420131)
- Testing
- QFR and iFR
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Contilia Clinical Research Institute
Cardiomyopathy, Coronary Artery Disease
The Prognostic Significance of Fibrosis Detection in Cardiomyopathy
The presence of scar within heart muscle can act as a substrate for abnormal rhythm problems and lead to the developement of heart failure Clinical significance Correlation with biomarkers and genetic markers
- Trial name
- NCT00930735
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Coronary Artery Disease
Ultra-high-resolution CT vs. Conventional Angiography for Detecting Coronary Heart Disease
Cardiac catheterization with invasive coronary angiography is the gold standard for determining the presence or absence of significant coronary heart disease (CHD).
- Trial name
- NCT04272060
- Testing
- CT angiography, Invasive coronary angiography
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 175 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease
Trans-Radial Coronary Interventions Using A Sheathless Guiding Catheter
Background: The transradial approach is increasingly used in percutaneous coronary intervention (PCI) because of lower major access site complications, lower bleeding risk and earlier patient mobilization.
- Trial name
- Sheathless-TRI (NCT01327365)
- Testing
- trans-radial PCI (TRI)
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University Hospital, Geneva
Heart Failure, Coronary Artery Disease
A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure
The purpose of this study is to assess the effectiveness and safety of rivaroxaban compared with placebo (inactive medication), in reducing the risk of death, myocardial infarction or stroke in participants with heart failure and…
- Trial name
- COMMANDER HF (NCT01877915)
- Testing
- Rivaroxaban, Standard of care for heart failure and coronary artery disease
- Where
- 562 sites in United States, Argentina and 30 more
- Volunteers
- 5,081 people
- Sponsor
- Janssen Research & Development, LLC
Ischemic Heart Disease, Coronary Artery Stenosis
AI-Enhanced Single-Lead ECG Screening for Coronary Stenosis
It is a prospective, controlled, single-center, non-randomized, observational study. Two patient groups are planned for inclusion: the first - 200 patients with significant coronary artery stenosis confirmed by coronary…
- Conditions
- Ischemic Heart Disease, Coronary Artery Stenosis, Stable Angina Pectoris, Acute Coronary Syndromes
- Trial name
- NCT07579624
- Testing
- single-channel electrocardiogram
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Cardiac Catheterization, Retina
Clinical Significance of Retinal Emboli During Diagnostic and Therapeutic Cardiac Catheterization
Retinal emboli is a common phenomenon in cardiac catheterization. In this study the investigators evaluate the incidence of retinal emboli post diagnostic and therapeutic cardiac catheterization over 300 patients.
- Conditions
- Cardiac Catheterization, Retina, Embolism
- Trial name
- NCT01157338
- Testing
- diagnostic cardiac catheterization, therapeutic cardiac catheterization
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Shiraz University of Medical Sciences
High Risk of Significant Coronary Artery Disease
Cardiac GSI Feasibility Study
The recently introduced Computed tomography (CT) scanner, Discovery CT750 HD (GE Healthcare, Milwaukee), incorporates a battery of innovations aimed at improving diagnostic image quality, evaluating perfusion and assessing for…
- Trial name
- NCT01816750
- Testing
- Cardiac GSI
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University Hospital Plymouth NHS Trust
Coronary Artery Disease
Firebird 2 Versus Excel Sirolimus-eluting Stent in Treating Real-world Patients With Coronary Artery Disease
Sirolimus-eluting stent (SES) has been world-widely used in clinical practice in treating patients with coronary artery disease (CAD).
- Trial name
- FESTA (NCT01373632)
- Testing
- Firebird 2 sirolimus-eluting stent, Excel sirolimus-eluting stent
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Heart Failure
Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart Failure
Heart failure is a major health problem worldwide. Optimal treatment of this disabling and fatal condition may require functional characterization of the failed left ventricle (LV) and its interaction with the arterial system.
- Trial name
- VACHF (NCT01156207)
- Testing
- Aliskiren
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hip Fracture
Troponin T Elevation in Patient Undergoing Hip Fracture Surgery
Background: Patients undergoing hip fracture surgery are elderly and usually have co-morbidities; hence they are at risk for perioperative MI.
- Trial name
- NCT01352754
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Significant Coronary Artery Disease
Coronary Hybrid Revascularisation Study
The purpose of the registry is to assess results of combined operative and catheter based (hybrid procedure) treatment of patients with significant coronary artery disease using essential clinical and angiographic parameters.
- Trial name
- NCT01496664
- Testing
- Combined CABG and PCI
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- Aarhus University Hospital Skejby