Clinical trials: Significant Coronary Artery Disease
Myocardial Ischemia
Assessment of Coronary Stenoses Using Coronary CT-angiography and Non-invasive Fractional Flow Reserve Measurement.
The purpose of this study is to determine whether a novel non-invasive method to estimate coronary blood flow (FFRct) is applicable to evaluate the functional significance of coronary stenoses in non-culprit vessels in a…
- Trial name
- NCT01739075
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
Left Main Coronary Artery
LMCA Treatment Outcome
Left main coronary artery (LMCA) is a major branch of coronary artery and supplies a large bulk of myocardium. Revascularization by either surgical coronary bypass grafting (CABG) or percutaneous coronary intervention (PCI) is…
- Trial name
- NCT06431516
- Where
- Hong Kong
- Volunteers
- 4,600 people
- Sponsor
- Chinese University of Hong Kong
Hodgkin Lymphoma Treated With Mediastinal Irradiation
Hybrid SPECT/CTCA for the Assessment of the Presence and Hemodynamic Significance of CAD in Asymptomatic Patients.
Mediastinal irradiation for treatment of malignancy increases the risk for coronary artery disease (CAD), while diabetes mellitus or other known risk factors can be absent at the time of the first coronary event.
- Trial name
- NCT01239446
- Testing
- Not relevant (there is no intervention in the present study)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Coronary Artery Disease, Non-significant Coronary Artery Disease
TweeSteden Mild Stenosis Study
Psychosocial factors have been found to be associated with an increased risk for coronary artery disease incidence, progression and worse clinical outcomes.
- Conditions
- Coronary Artery Disease, Non-significant Coronary Artery Disease, Mild Stenosis, Vascular Irregularities
- Trial name
- TWIST (NCT01788241)
- Where
- Netherlands
- Volunteers
- 547 people
- Sponsor
- Tilburg University
Coronary Artery Disease, Ischemia and No Obstructive Coronary Arteries
Coronary Microcirculatory Disease and Inflammation in Patients With Chronic Coronary Syndrome and no Significant Coronary Artery Stenosis
Patients with chronic coronary syndromes (CCS) diagnosed without significant lesions in invasive coronary angiography (ischemia non-obstructive coronary artery disease - INOCA) represent approximately 50% of all patients with…
- Conditions
- Coronary Artery Disease, Ischemia and No Obstructive Coronary Arteries, Ischemic Heart Disease, Microvascular Angina
- Trial name
- MOSAIC-COR (NCT05313919)
- Testing
- Comprehensive functional diagnostics of coronary circulation
- Where
- Poland
- Volunteers
- 160 people
- Sponsor
- Bartlomiej Guzik
MINOCA
Prognostic Significance of CMR-Confirmed Infarct in MINOCA Patients from Sweden and Australia
Myocardial Infarction (MI) with Non-Obstructive Coronary Arteries (MINOCA), occurring in 6-8% of MIs, refers to patients who experience a heart attack without obstructive coronary artery disease (CAD) or significant…
- Trial name
- SWEET (NCT06889428)
- Testing
- CMR
- Where
- Australia
- Volunteers
- 1,000 people
- Sponsor
- University of Adelaide
Cardiovascular Disease
Prognostic Value of Endothelial Dysfunction and Coronary Complexity
The investigators test the additional clinical value of the physiological assessment of endothelial function to the morphological assessment of coronary complexity and classical risk score in predicting cardiovascular events.
- Trial name
- NCT00737945
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Kumamoto University
Hemodialysis, Coronary Arterial Disease (CAD)
Predictive Tools for the Presence of Significant Coronary Artery Disease Requiring Intervention in Chronic Hemodialysis Patients
Medical record data of all HD patients undergoing coronary angiography (CAG) at King Chulalongkorn Memorial Hospital between January 2017 and March 2021 were retrospectively reviewed as a discovery cohort to identify factors…
- Conditions
- Hemodialysis, Coronary Arterial Disease (CAD), ESRD (End Stage Renal Disease)
- Trial name
- CAD in HD (NCT06661941)
- Where
- Thailand
- Volunteers
- 149 people
- Sponsor
- Chulalongkorn University
Coronary Artery Disease
Frank Score and Coronary Artery Disease
Patients with coronary artery disease (CAD) were enrolled. CAD was diagnosed by coronary angiography which also resulted Syntax score. Images of left and right ears were captured by a digital camera.
- Trial name
- NCT03177486
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Shaanxi Provincial People's Hospital
Acute ST-elevation Myocardial Infarction
Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction.
Heart imaging with magnetic resonance imaging (MRI) provides detailed insights into heart function and injury. The nature and significance of heart injury after a heart attack is incompletely understood.
- Trial name
- BHF MR-MI (NCT02072850)
- Testing
- Coronary pressure wire, Magnetic resonance imaging of the heart
- Where
- United Kingdom
- Volunteers
- 324 people
- Sponsor
- NHS National Waiting Times Centre Board
ST-Elevation Myocardial Infarction
Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance - Impact on Outcome
In acute myocardial infarction cardiovascular magnetic resonance imaging can retrospectively detect the myocardium at risk and the irreversible injury.
- Trial name
- NCT00952224
- Testing
- magnetic resonance imaging
- Where
- Germany
- Volunteers
- 267 people
- Sponsor
- University of Leipzig
Coronary Heart Disease
Could Non-invasive Biochemical, Image or Physiological Index Predict Significant Coronary Arterial Stenosis in Symptomatic Adults?
To validate the capability of non-invasive bio-image tests in prediction of significant coronary stenosis of symptomatic adults.
- Trial name
- NCT01645228
- Testing
- coronary calcium score measurement, high sensitivity C reactive protein measurement, ankle brachial index measurement
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cathay General Hospital
Coronary Heart Disease
Analysis of Coronary CT Angiography to Identify Patients With Significant Coronary Artery Stenosis
The investigators propose to develop a computational framework involving a novel automatic image segmentation algorithm based on CTA images, an artery model reconstruction algorithm for stenosis detection, and quantification of…
- Trial name
- CTAAnalyzer (NCT02791113)
- Testing
- Fractional Flow Reserve (FFR) Measurement
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National Heart Centre Singapore
Chronic Coronary Syndromes
Detection of Significant Coronary Artery Disease by Promising Biomarker: A2A Adenosine Receptor (A2AR) Assays
Transversal, national, multi-center study with progressive recruitment designed to assess the diagnostic accuracy of A2AR expression for the identification of significant obstructive CAD (FFR<0.8) of patients suspected of CCS…
- Trial name
- ADOCAD (NCT05091749)
- Testing
- blood samples
- Where
- France
- Volunteers
- 312 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Coronary Artery Disease
Side Branch FFR After Provisional Stenting
The purpose of this study is to predict any changes in the side branch after stenting the main branch blood vessel using three dimensional intravascular images. (Frequency domain optical coherence tomography FD OCT).
- Trial name
- ORBID-FFR (NCT03115580)
- Testing
- Rotational atherectomy, Cutting Balloon Angioplasty
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiovascular Abnormalities
Heartflow (AFFECTS)
The overall objective of the AFFECTS Study is to assess agreement between SPECT and FFRct in identifying vessel-specific, hemodynamically significant CAD in patients scheduled for invasive coronary angiography (ICA) based on…
- Trial name
- AFFECTS (NCT02973126)
- Testing
- FFRct and SPECT
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Baylor Research Institute
Ischemic Heart Disease
EWISE: Study of Eplerenone in Women With Chest Pain, Coronary Vascular Dysfunction and Evidence of Myocardial Ischemia
Some women have chest pain even without having a blockage in one of the major blood vessels that supplies blood to the heart. In many of these women the microscopic (small) blood vessels in the heart do not function normally.
- Trial name
- NCT00187889
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Florida
Coronary Artery Disease
Assessing the Efficacy of CARDIOgoniometry (CGM) to Determine Physiologically Significant Stenosis in Patients With Stable Coronary Artery Disease in Comparison to Fractional FLOW Reserve - CARDIOFLOW
The CARDIOFLOW study compares the standard test, a pressure wire test called fractional flow reserve (FFR), with a new method that is based on taking a detailed "3D" ECG called Cardiogoniometry (CGM).
- Trial name
- CARDIOFLOW (NCT02815631)
- Testing
- Cardiogoniometry (CGM), Fractional Flow Reserve (FFR)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease
Positive Association of US-FLI With the Severity of CAD
As a multisystem disease, metabolic dysfunction-associated fatty liver disease (MAFLD) is closely linked to the onset and progression of coronary heart disease (CHD).
- Conditions
- Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease, SYNTAX Score, Ultrasonography
- Trial name
- NCT06541132
- Testing
- Observational study without human intervention
- Where
- China
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Coronary Artery Disease, Coronary Stenosis
SEA-SIDE: Sirolimus Versus Everolimus-eluting Stent Randomized Assessment in Bifurcated Lesions and Clinical SIgnificance of Residual siDE-branch Stenosis
BACKGROUND: Bifurcated lesions are a challenging subset in percutaneous coronary interventions (PCI). The selection of the type of DES and the technique for stent implantation have not been clarified.
- Trial name
- SEA-SIDE (NCT00697372)
- Testing
- Sirolimus eluting stent, Everolimus eluting stent
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Catholic University of the Sacred Heart