Clinical trials: Significant Coronary Artery Disease
Coronary Stenosis, Coronary Artery Disease
Percutaneous Coronary Intervention (PCI) With Drug-Eluting Stents (DES) Versus Coronary Artery Bypass Graft (CABG) for Patients With Significant Left Main Stenosis
Recent technical advances in percutaneous coronary interventions have made it possible to approach patients with coronary lesions formerly considered to be classical candidates for bypass surgery, e.g.
- Trial name
- NCT00176397
- Testing
- Percutaneous coronary intervention (left main)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Leipzig
Cardiomyopathies, Microcirculation
IMR Assessment in Patients With New Diagnosis of Left Ventricle Dilatation
To establish if, in patients with new diagnosis of left ventricular dilatation without documentation at the coronary artery angiography of significant coronary artery lesions, there is a damage of the coronary microcirculation at…
- Conditions
- Cardiomyopathies, Microcirculation, Microvessels
- Trial name
- IMPAIRED (NCT02705170)
- Testing
- index of microvascular resistance
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital of Ferrara
Chest Pain, Coronary Heart Disease Risk
Comparison of the Cost-Effectiveness of Coronary CT Angiography Versus Myocardial SPECT in Patients With Intermediate Risk of Coronary Heart Disease
The investigators aim to compare the cost-effectiveness of CCTA and myocardial SPECT in patients with intermediate pre-test probability of CHD.
- Trial name
- CARE-CCTA (NCT01542086)
- Testing
- Myocardial SPECT, 64-channel coronary CT angiography (CCTA)
- Where
- South Korea
- Volunteers
- 1,050 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. But patients may have more than one narrowing and studies have shown that not all narrowings need to be treated.
- Trial name
- DEFINE-FLAIR (NCT02053038)
- Testing
- iFR, FFR
- Where
- 50 sites in United States, Australia and 15 more
- Volunteers
- 2,500 people
- Sponsor
- Imperial College London
Ischemic Mitral Regurgitation
Effect of Significant Ischemic Mitral Regurgitation on the Outcome of ST Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention
The goal of the study is to correlate the effect of ischemic mitral regurgitation on the outcome of STEMI patients treated with successful primary PCI using clinical data and echocardiography on presentation and during short term…
- Trial name
- NCT04106648
- Volunteers
- 134 people
- Sponsor
- Assiut University
Coronary Artery Disease, Magnetic Resonance Angiography
Correlation Between Quantitative Analysis of Coronary MRA and FFR
This study aims to evaluate whether quantitative analysis of coronary MR angiogram would improve the detection of functionally-significant coronary artery stenosis.
- Conditions
- Coronary Artery Disease, Magnetic Resonance Angiography, Fractional Flow Reserve
- Trial name
- NCT03117218
- Testing
- Coronary MR angiography
- Where
- South Korea
- Volunteers
- 89 people
- Sponsor
- Seoul National University Bundang Hospital
Angina Pectoris
Women With Chest Pain and no Significant Coronary Artery Stenosis; A Study on Microvascular Resistance
Female patients presenting with persistent chest pain despite no obstructive coronary artery disease have impaired prognosis. Stress tests are often positive or inconclusive.
- Trial name
- NCT01582165
- Testing
- Rosuvastatin
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- Oslo University Hospital
Coronary Artery Disease
TREAT Study - Improving the Interpretation of Troponin Concentrations Following Exercise and Their Clinical Significance
The goal of this observational study is to learn about cardiac biomarker release following exercise in amateur athletes. The main questions it aims to answer are: Question 1: What are the reference values for exercise-induced…
- Trial name
- TREAT (NCT06295081)
- Testing
- Exercise exposure
- Where
- Netherlands
- Volunteers
- 1,015 people
- Sponsor
- Radboud University Medical Center
Heart Failure With Preserved Ejection Fraction, Coronary Microvascular Dysfunction
Distribution and Clinical Implication of CMD in Patients With HFpEF Without Significant CAD
To evaluate the incidence of coronary microvascular dysfunction (CMD) and its' prognostic implication in patients who have diagnosed as heart failure with preserved ejection fraction (HFpEF) confirmed by HFA-PEFF scoring system…
- Trial name
- HFpEF-CMD (NCT04788576)
- Testing
- Invasive physiologic evaluation (fractional flow reserve, coronary flow reserve, index of microcirculatory resistance)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Myocardial Ischemia
Evaluation of Accuracy of CFD-based RuiXin-FFR by Comparing With Pressure-wire-based FFR
Coronary Artery Disease (CAD) is the top killer nowadays. Pressure-wire-based Fractional Flow Reserve (FFR) is the gold standard for measuring ischemia in coronary arteries.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Myocardial Fractional Flow Reserve
- Trial name
- NCT04731285
- Testing
- Pressure wire fractional flow reserve, CFD-based RuiXin-FFR
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease
High Definition CT Coronary Angiography Accuracy Trial
CT technology is evolving at a rapid pace, with introduction of multidetector row CT scanners (MDCT) and electrocardiographic (ECG) gating resulting in increasing numbers of heart scans CTCA (CT Coronary Angiography).
- Trial name
- NCT01946737
- Testing
- HD-CTCA with Adaptive statistical iterative reconstruction (ASIR), Active Comparator: Invasive coronary angiography (ICA)
- Where
- United Kingdom
- Volunteers
- 302 people
- Sponsor
- University Hospital Plymouth NHS Trust