Clinical trials: Sildenafil
Waldenstrom's Macroglobulinemia
Sildenafil Citrate in Waldenstrom's Macroglobulinemia
The purpose of this study is to determine the effects (good or bad) that sildenafil (Viagra) has on patients with slow growing Waldenstrom's macroglobulinemia (WM).
- Trial name
- NCT00165295
- Testing
- Sildenafil citrate (Viagra)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute
Anovulatory
The Effect of Sildenafil Citrate on the Success Rate of Ovulation Induction Using Clomiphene
The aim of the study is to evaluate the effect of sildenafil citrate on the pregnancy rate in women undergoing induction of ovulation using clomiphene citrate.
- Trial name
- NCT02663830
- Testing
- Sildenafil & clomiphene citrate, clomiphene only
- Volunteers
- 210 people
- Sponsor
- Ain Shams University
Oligohydramnios
Comparison Between Treatments of Oligohydramnios
Based on previous studies, Both sildenafil and L-arginine helped to improve idiopathic oligohydramnios. In this study, Level of improvment of oligohydramnios will be compared.
- Trial name
- NCT07135037
- Testing
- Sildenafil 25 MG, L-Arginine, 1000 Mg Oral Tablet
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Impotence
Titration Study to Evaluate Efficacy and Satisfaction of Viagra in Men With Erectile Function.
To evaluate the efficacy of Viagra dose titration to 100mg versus 50mg in men with erectile dysfunction, based on responses to the IIEF questionnaire as measured at the beginning and at the end of double blind treatment…
- Trial name
- NCT00249730
- Testing
- Sildenafil
- Where
- 39 sites in Canada, France and 6 more
- Volunteers
- 510 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Fetal Growth Retardation
A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction
This is a Randomized Controlled Trial to evaluate the effect of sildenafil on Doppler velocity indices of the umbilical arteries in patients with placental insufficiency and fetal growth restriction, and if sildenafil can improve…
- Trial name
- NCT02590536
- Testing
- Sildenafil citrate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Pulmonary Arterial Hypertension
Effects of Oral Sildenafil on Mortality in Adults With PAH
This is a blinded study in adult patients with PAH evaluating the relative effects of sildenafil on mortality when administered at the three doses (80 mg, 20 mg or 5 mg, all three times per day [TID]).
- Trial name
- AFFILIATE (NCT02060487)
- Testing
- sildenafil citrate
- Where
- 82 sites in United States, Australia and 21 more
- Volunteers
- 385 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Bronchopulmonary Dysplasia
Safety of Sildenafil in Premature Infants
Describe the safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia and determine preliminary effectiveness and pharmacokinetics (PK) of sildenafil.
- Trial name
- SIL02 (NCT03142568)
- Testing
- Sildenafil
- Where
- 15 sites in United States, Canada
- Volunteers
- 109 people
- Sponsor
- University of North Carolina, Chapel Hill
Lung Diseases
The Effect of Sildenafil in Preterm Infants With Evolving Chronic Lung Disease
The purpose of this pilot study is to investigate in a randomised double-blind trial whether treatment with Sildenafil reduces duration of ventilatory support in preterm infants born at 28 weeks of gestation or less.
- Trial name
- NCT00431418
- Testing
- Sildenafil
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Mercy Hospital for Women, Australia
Hernia, Diaphragmatic, Hypertension, Pulmonary
Chronic Sildenafil for Severe Diaphragmatic Hernia
The purpose of this study is to test if sildenafil is effective in the treatment of infants with severe congenital diaphragmatic hernia (determined by the presence of prolonged pulmonary hypertension or prolonged oxygen…
- Conditions
- Hernia, Diaphragmatic, Hypertension, Pulmonary, Hypoplasia, Pulmonary
- Trial name
- NCT00133679
- Testing
- sildenafil
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Edema, Pulmonary, Immersion
Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) Prevention
This trial is testing the effectiveness of a single oral dose of sildenafil (50 mg) taken 1 hour before a provocative event on the subsequent development of swimming-induced pulmonary edema.
- Conditions
- Edema, Pulmonary, Immersion, Diving
- Trial name
- NCT03686813
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Bronchopulmonary Dysplasia of Newborn
Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia
This is a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study of sildenafil in premature infants (inpatient in Neonatal Intensive Care Units (NICUs)) with severe bronchopulmonary…
- Trial name
- SILDI-SAFE (NCT04447989)
- Testing
- Sildenafil
- Where
- 25 sites in United States
- Volunteers
- 125 people
- Sponsor
- Christoph Hornik
Mild to Moderate Hypertension
Evaluation of Drug-drug Interaction Between LCZ696 and Sildenafil in Subjects With Mild to Moderate Hypertension
This study was conducted to investigate the potential for a pharmacokinetic drug-drug interaction in support of the co-administration of LCZ696 and sildenafil.
- Trial name
- NCT01601470
- Testing
- LCZ696, Sildenafil
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Hand Foot Skin Reaction
Topical Sildenafil as Pre-Treatment for Hand-Foot Skin Reaction
Skin toxicities are a major complication to cancer therapies. They can be painful and limit the amount of drug that can be received by cancer patients, preventing the patients from receiving optimal doses of drug.
- Trial name
- NCT03229512
- Testing
- Sildenafil
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Northwestern University
Cystic Fibrosis
Safety and Efficacy of Sildenafil in Cystic Fibrosis (CF) Lung Disease
The purpose of this study is to determine whether sildenafil can decrease inflammation in CF lung disease.
- Trial name
- NCT00659529
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Jewish Health
Duchenne Muscular Dystrophy
Tadalafil and Sildenafil for Duchenne Muscular Dystrophy
This study, supported by Parent Project Muscular Dystrophy, will determine if tadalafil or sildenafil can improve muscle blood flow during exercise in boys with Duchenne muscular dystrophy.
- Trial name
- NCT01359670
- Testing
- Tadalafil, Sildenafil
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Persistent Pulmonary Hypertension of the Newborn
IV Sildenafil Persistent Pulmonary Hypertension Of The Newborn
To determine the efficacy of iv sildenafil in term and near term infants with PPHN (persistent pulmonary hypertension of the newborn), by measuring the need for inhaled nitric oxide (iNO) or extracorporeal membrane oxygenation…
- Trial name
- NCT01360671
- Testing
- Sildenafil
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Parkinsons Disease, Erectile Dysfunction
Motor Response to Sildenafil in PD
Sildenafil (Viagra(R))is widely used by men with Parkinsons Disease (PD) and erectile dysfunction. A number of patients have reported that when they take Sildenafil, their need of anti-PD medication is reduced.
- Trial name
- NCT01941732
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Bispebjerg Hospital
Infertility, Female
Effect of Oral Sildenafil Citrate on Improvement of Endometrial Thickness
One hundred thirty women with unexplained infertility participated in a prospective clinical study. Patients were assigned at random to one of two groups.
- Trial name
- NCT05846906
- Testing
- Sildenafil Citrate, Clomiphene Citrate 50mg
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Pulmonary Arterial Hypertension
Hemodynamic Response After Six Months of Sildenafil
The purpose of this study is to determine the clinical, functional and hemodynamic response after six months of sildenafil 50 mg TID in patients with pulmonary arterial hypertension.
- Trial name
- NCT00483626
- Testing
- oral sildenafil
- Where
- Chile
- Volunteers
- 27 people
- Sponsor
- University of Chile
Female Infertility
Clomiphene Citrate, Estradiol and Sildenafil for Induction of Ovulation in Unexplained Infertility
Diagnosis of unexplained infertility is made after the recommended testing fails to reveal any abnormality. The treatment for unexplained infertility is empiric because it does not address a specific defect or functional…
- Trial name
- NCT03755037
- Testing
- Clomid, Respatio and Ethinyl estradiol
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Nesreen Abdel Fattah Abdullah Shehata