Clinical trials: Silent Stroke
Silent Stroke, Silent Cerebral Infarct
Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions
The CBI registry is a prospective, interdisciplinary, multimodal observational registry of patients with covert brain infarction.
- Conditions
- Silent Stroke, Silent Cerebral Infarct, Covert Brain Infarct, Covert Brain Infarction
- Trial name
- CBI-Registry (NCT05685069)
- Where
- 2 sites in France, Switzerland
- Volunteers
- 230 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Internal Carotid Artery Stenosis
SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy
SONOBIRDIE Trial is a randomized, single-blind, sham-controlled study designed for a demonstration of the safety and effectiveness of sonolysis (continual transcranial Doppler (TCD) monitoring) in reduction of risk of stroke or…
- Trial name
- SONOBIRDIE (NCT02398734)
- Testing
- sonolysis
- Where
- Czechia
- Volunteers
- 1,492 people
- Sponsor
- University Hospital Ostrava
Brain Infarction
Antiplatelet Therapy for Silent Brain Infarction
Silent brain infarction (SBI) or incidental infarct is common. Recent studies revealed individuals with SBI have an increased risk of future stroke.
- Trial name
- ANTISBI (NCT03318744)
- Testing
- Aspirin
- Where
- China
- Volunteers
- 3,400 people
- Sponsor
- First People's Hospital of Shenyang
Stroke, Acute
ERILs Und SNILs Unter SOC
1. How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment? 2. How many SNILs occur between 7 and 30 days after acute ischemic event on standard treatment? 3.
- Trial name
- NCT05786170
- Testing
- diffusion-weighted magnetic resonance imaging
- Sponsor
- Medical University of Vienna
Neurological Disorder
Multidisciplinary Lifestyle Interventions for Neurological Disorders During the Silent Phase
This clinical trial aims to test the impact of multidisciplinary lifestyle interventions (MLI) in neurologically healthy but at-risk individuals.
- Trial name
- MINDS (NCT05984056)
- Testing
- Multidisciplinary lifestyle interventions
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vineet Punia MD
Silent Stroke, Coronary Disease
Evaluation of Brain Damage Due to Coronary Angioplasty in Percutaneous Intervention Patients
This study examines the formation mechanism and patient-related factors of silent cerebral infarcts, whose importance has become increasingly recognized in patients undergoing percutaneous coronary intervention.
- Trial name
- NCT04734587
- Testing
- Blood serum Neuron-specific Enolase measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ondokuz Mayıs University
Coronary Artery Bypass Graft Redo, Heart Valve Diseases
SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- SONORESCUE (NCT01591018)
- Testing
- sonolysis, cardiac surgery
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Stroke, Silent Cerebral Infarction
Intervention With Cerebral Embolic Protection in TEVAR: Gaseous Protection
Vascular brain infarction (VBI) occurs in 67% of patients undergoing TEVAR. Overt stroke occurs in 13% of these patients and 88% of patients suffer from neurocognitive impairment.
- Conditions
- Stroke, Silent Cerebral Infarction, Neurocognitive Dysfunction, Vascular Brain Injury
- Trial name
- INTERCEPT:GP (NCT03886675)
- Testing
- CO2 flushing, Saline flushing
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Stroke, Silent Cerebral Infarct
Total Cerebral Protection With Embolic Protection Devices Thoracic Aortic Stenting
Stroke and silent cerebral infarction are a real risk with thoracic enodvascular aortic repair (TEVAR). The investigator propose to prospectively observational study with enrolment of all patients undergoing TEVAR for thoracic…
- Trial name
- NCT04062539
- Testing
- Sentinel and Spider
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Right-to-left Shunt, Migraine
Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population
The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.
- Conditions
- Right-to-left Shunt, Migraine, Cerebral Infarction
- Trial name
- NCT02425696
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Yingqi Xing
Aortic Arch Aneurysm
Silent Brain Infarction After Endovascular Arch Procedures
This is the largest study to evaluate incidence and distribution of silent cerebral infarction (SBI) following endovascular repair for disease of the aortic arch.
- Trial name
- NCT04489277
- Testing
- Endovascular Arch Procedures
- Where
- 2 sites in France, Germany
- Volunteers
- 91 people
- Sponsor
- Medical University of Vienna
Silent Stroke, Cognitive Decline
Detection and Neurological Impact of Cerebrovascular Events in Cardiac Surgery Patients
The investigators conducted a prospective observational pilot study to explore the incidence of peri-operative covert strokes (detected by brain MRI) and the potential impact on delirium and cognitive decline in post-operative…
- Trial name
- NCT04241289
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Population Health Research Institute
Silent Stroke, Pulmonary Embolism
Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO)
Pulmonary embolism is associated with a small but definite risk of paradoxical embolism in patients with a patent foramen ovale (PFO).
- Conditions
- Silent Stroke, Pulmonary Embolism, Patent Foramen Ovale
- Trial name
- ICEP (NCT00831259)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Caen
Ischemic Cerebrovascular Accident
Stepwise Screening for Silent Atrial Fibrillation After Stroke
The main hypothesis of this work is that an approach combining clinical parameters and biomarker assays could improve the understanding and prediction of the occurrence of silent atrial fibrillation (AF) in the acute phase after…
- Trial name
- SAFAS (NCT03570060)
- Testing
- Blood sample, Long term ECG monitor, Monitoring ECG
- Where
- France
- Volunteers
- 264 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cerebral Infarction
Identification the Cause of Silent Cerebral infarctiON in Healthy Subjects (ICONS)
We hypothesized that paradoxical embolism may be one of the main mechanisms of silent cerebral infarction (SCI) located outside the perforating artery territory.
- Trial name
- ICONS (NCT01429948)
- Where
- South Korea
- Volunteers
- 581 people
- Sponsor
- Samsung Medical Center
Stroke
Evaluating the Effects of Hormone Replacement Therapy on Brain Function (The WHIMS-MRI Study)
A silent stroke is a type of stroke that does not produce any severe symptoms, but may slightly affect memory or thinking abilities.
- Trial name
- WHIMS-MRI (NCT00739869)
- Where
- United States
- Volunteers
- 1,426 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Symptomatic Paroxysmal Atrial Fibrillation
Mesh Ablator Versus Cryoballoon Pulmonary Vein Ablation of Symptomatic Paroxysmal Atrial Fibrillation
The purpose of this prospective randomized single-center trial is to compare efficiency and safety of two pulmonary vein ablation systems in patients with symptomatic paroxysmal atrial fibrillation using the Arctic Front® versus…
- Trial name
- MACPAF (NCT01061931)
- Testing
- Arctic Front® catheter vs. HD Mesh Ablator® catheter
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Charite University, Berlin, Germany
Mitral Regurgitation, Silent Stroke
Silent sTROke duriNG MitraClip Implantation
The MitraClip-procedure offers an interventional treatment for high risk patients with severe symptomatic mitral regurgitation. The number of new cerebral ischemic lesions without clinical manifestations is high.
- Trial name
- STRONG (NCT03104556)
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Charite University, Berlin, Germany
Myocardial Infarction, Acute Disease
Imaging Silent Brain Infarct And Thrombosis in Acute Myocardial Infarction
This project aims to assess the ability of cardiac imaging (cardiac MRI and Doppler-echocardiography) post-processing tools to predict a combined end-point of intraventricular thrombosis, silent brain infarcts, clinical stroke…
- Conditions
- Myocardial Infarction, Acute Disease, Thrombosis, Heart Diseases
- Trial name
- ISBITAMI (NCT02917213)
- Testing
- Doppler echocardiogram exam, Carotid duplex ultrasound exam, Cardiac MRI
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Silent Stroke
Association Between Gait Assessed by Intelligent System and Cognitive Function in Silent Cerebrovascular Disease
This study is a multi-center prospective cohort study. We will continuously recruit subjects with silent cerebrovascular disease aged 60 to 85 years from Shanghai and Guizhou.
- Trial name
- ACCURATE-2 (NCT04456348)
- Testing
- there is no intervention
- Volunteers
- 1,600 people
- Sponsor
- Shanghai Zhongshan Hospital